Cytochrome P4502E in vivo and in vitro in the dwarf goat: Effects of enzyme induction and the applicability of chlorzoxazone as marker substrate

Journal of Veterinary Pharmacology and Therapeutics

Volumn 19, Issue 3, 1996, Pages 245-250

  Zweers Zeilmaker, W M ^a,b   Maas, R F M ^a   Horbach, G J ^a   Van Miert, A S J P A M ^a   Witkamp, R F ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NONE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROPHENOL; ANILINE; BETA NAPHTHOFLAVONE; CHLORZOXAZONE; CYTOCHROME P450 ISOENZYME; ENZYME INDUCING AGENT; ISONIAZID; MARKER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG URINE LEVEL; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME SUBSTRATE; FEMALE; GOAT; HYDROXYLATION; IMMUNOBLOTTING; INTRAVENOUS DRUG ADMINISTRATION; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; CAPRA HIRCUS;

EID: 0029991666     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2885.1996.tb00045.x     Document Type: Article

References (25)

1. Bellward, G.D., Chang, T., Rodrigues, B., McNeill, J.H., Maines, S., Ryan, D.E., Levin, W. & Thomas, P.E. (1988) Hepatic cytochrome P-450j induction in the spontaneously diabetic BB rat. Molecular Pharmacology, 33, 140-143.
2. Carriere, V., Goasduff, T., Ratanasavanh, D., Morel, F., Gautier, J.C., Guillouzo, A., Beaune, P. & Berthou, F. (1993) Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone. Chemical Research in Toxicology, 6, 852-857.
3. Chhabra, R.S., Gram, T.E. & Fouts, J.R. (1972) A comparative study of two procedures used in the determination of hepatic microsomal aniline hydroxylation. Toxicology and Applied Pharmacology, 22, 50-58.
4. Girre, C., Lucas, D., Hispard, E., Menez, C., Dally, S. & Menez, J.F. (1994) Assesment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics. Biochemical Pharmacology, 47, 1503-1508.
5. Guengerich, F.P., Kim, D. & Iwasaki, M. (1991) Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chemical Research in Toxicology, 4, 168-179.
6. Heinzel, G., Woloszcak, R. & Thomann, P. (1993) TopFit 2.0. Pharmacokinetic and pharmacodynamic data analysis system for the PC. Gustav Fischer Verlag, Stuttgart.
7. Imai, Y., Ito, A. & Sato, R. (1966) Evidence for biochemically different types of vesicles in the hepatic microsomal fraction. Journal of Biochemistry, 60, 417-428.
8. Kaneko, I., Takeuchi, Y., Fukumori, Y. & Fukuda, T. (1991) Effect of alpha-chloralose on disposition and pharmacological action of orally administered chlorzoxazone in rats. Journal of Pharmacobio-Dynamics, 14, 429-434.
9. Kharasch, E.D., Thummel, K.E., Mhyre, J. & Lillibridge, J.H. (1993) Single-dose disulfiram inhibition of chlorzoxazone metabolism: A clinical probe for P450 2E1. Clinical Pharmacology & Therapeutics, 53, 643-650.
10. Koop, D.R., Crump, B.L., Nordblom, G.D. & Coon, M.J. (1985) Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: ethanol. imidazole, trichloroehylene, acetone, pyrazole and isoniazid. Proceedings of the National Academy of Sciences, 82, 4065-4069.
11. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685.
12. Lam, F.C., Hung, C.T. & Perrier, D.G. (1985) Estimation of variance of harmonic mean half-lives. Journal of Pharmaceutical Sciences, 74, 229-231.
13. Lowry, O.H., Rosebrough, N.J., Farr, A.L. & Randall, R.J. (1951) Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193, 265-275.
14. Peter, R., Bocker, R., Beaune, P.H., Iwasaki, M., Guengerich, F.P. & Yang, C.S. (1990) Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1. Chemical Research in Toxicology, 3, 566-573.
15. Raucy, J.L., Lasker, J.M., Lieber, C.S. & Black, M. (1989) Acetaminophen activation by human liver cytochromes P450IIE1 and P4501A2. Archives of Biochemistry and Biophysics, 271, 270-283.
16. Raucy, J.L., Kraner, J.C. & Lasker, J.M. (1993) Bioactivation of halogenated hydrocarbons by cytochrome P4502E1. Critical Reviews in Toxicology, 23 (1), 1-20.
17. Reinke, L.A. & Moyer, M.J. (1985) p-Nitrophenol hydroxylation: A microsomal oxidation which is highly inducible by ethanol. Drug Metabolism and Disposition, 13, 548-552.
18. Rutten, A.A.J.J.L., Falke, H.E., Catsburg, J.F., Topp, R., Blaauboer, B.J., Holsteyn van, I., Doorn, L. & Leeuwen van, F.X.R. (1987) Interlaboratory comparison of total cytochrome P450 and protein determinations in rat liver microsomes. Archives of Toxicology, 61, 27-33.
19. Ryan, D.E., Ramanathan, L., Iida, S., Thomas, P.E., Haniu, M., Shively, J.E., Lieber, C.S. & Levin, W. (1985) Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid. The Journal of Biological Chemistry, 260, 6385-6393.
20. Thummel, K.E., Kharasch, E.D., Podoll, T. & Kunze, K. (1995) Human liver microsomal enflurane defluorination catalyzed by cytochrome P-450 2E1. Drug Metabolism and Disposition, 21, 350-357.
21. Towbin, H., Staehelin, T. & Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proceedings of the National Academy of Sciences, 76, 4350-4354.
22. Tsutsumi, M., Lasker, J.M., Takahashi, T. & Lieber, C.S. (1993) In vivo induction of hepatic P4502E1 by ethanol: Role of increased enzyme synthesis. Archives of Biochemistry and Biophysics, 304, 209-218.
23. Winters, D.K. & Cederbaum, A.I. (1992) Time course characterization of the induction of cytochrome P-450 2E1 by pyrazole and 4-methylpyrazole. Biochimica et Biophysica Acta, 1117, 15-24.
24. Wortelboer, H.M., Kruif de, C.A., Iersel van, A.A.J., Falke, H.E., Noordhoek, J. & Blaauboer, B.J. (1991) Comparison of cytochrome P450 isoenzyme profiles in rat liver and hepatocyte cultures: the effects of model inducers on apoproteins and biotransformation activities. Biochemical Pharmacology, 42, 381-390.
25. Zand, R., Nelson, S.D., Slattery, J.T., Thummel, K.E., Kalhorn, T.F., Adams, S.P. & Wright, J.M. (1993) Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans. Clinical Pharmacology & Therapeutics, 54, 142-149.