Monolithic silica rod liquid chromatography with ultraviolet or fluorescence detection for metabolite analysis of cytochrome P450 marker reactions

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 780, Issue 2, 2002, Pages 205-215

  Lutz, E S Mareike ^a   Markling, M E ^a   Masimirembwa, C M ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Cytochrome P450; Monolithic silica rod

Indexed keywords

FLUORESCENCE; LIQUID CHROMATOGRAPHY; METABOLITES; ULTRAVIOLET RADIATION;

POROUS SILICA COLUMN;

CHROMATOGRAPHIC ANALYSIS;

1 HYDROXYBUFURALOL; 1 HYDROXYMIDAZOLAM; 4 HYDROXYDICLOFENAC; 4 HYDROXYMEPHENYTOIN; 6 HYDROXYCHLORZOXAZONE; 6ALPHA HYDROXYPACLITAXEL; BUFURALOL; CHLORZOXAZONE; COUMARIN; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DICLOFENAC; DICLOFENAC DERIVATIVE; DRUG METABOLITE; MEPHENYTOIN; MIDAZOLAM; PACLITAXEL; PACLITAXEL DERIVATIVE; PARACETAMOL; PHENACETIN; SILICON DIOXIDE; UMBELLIFERONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ISOENZYME;

ARTICLE; CHEMICAL ANALYSIS; ENZYME ANALYSIS; FLUORESCENCE; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; REACTION ANALYSIS; ULTRAVIOLET RADIATION; CHEMISTRY; METABOLISM; METHODOLOGY; SPECTROFLUOROMETRY; ULTRAVIOLET SPECTROPHOTOMETRY;

CYTOCHROME P-450 ENZYME SYSTEM; ISOENZYMES; SILICON DIOXIDE; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0037175432     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(02)00264-7     Document Type: Article

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