Specific ligand for a central type prostacyclin receptor attenuates neuronal damage in a rat model of focal cerebral ischemia

Brain Research

Volumn 925, Issue 2, 2002, Pages 176-182

  Takamatsu, Hiroyuki ^a   Tsukada, Hideo ^b   Watanabe, Yumiko ^c   Cui, Yilong ^c   Kataoka, Yosky ^c   Hosoya, Takamitsu ^d   Suzuki, Masaaki ^d   Watanabe, Yasuyoshi ^c,e  

^a Medical and Pharmacological Research Center Foundation   (Japan)

^b CENTRAL RESEARCH LABORATORY   (Japan)

^c OSAKA BIOSCIENCE INSTITUTE   (Japan)

^d GIFU UNIVERSITY   (Japan)

^e OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Focal ischemia; IP2; Middle cerebral artery occlusion; Prostacyclin

Indexed keywords

ESTER DERIVATIVE; ILOPROST; PROSTACYCLIN RECEPTOR; TRITIUM;

ANIMAL EXPERIMENT; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; EVALUATION; ISOTOPE LABELING; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; STROKE;

ANIMALS; BRAIN; BRAIN CHEMISTRY; BRAIN INFARCTION; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOPROSTENOL; INFARCTION, MIDDLE CEREBRAL ARTERY; INJECTIONS, INTRAVENOUS; LIGANDS; MALE; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, EPOPROSTENOL; RECEPTORS, PROSTAGLANDIN;

EID: 0037169210     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)03280-2     Document Type: Article

References (30)

1. Expression of interleukin-1 beta converting enzyme gene family and bcl-2 gene family in the rat brain following permanent occlusion of the middle cerebral artery
2. 5-Hydroxytryptamine1A agonists. A new therapeutic principle for stroke treatment
3. Early endonuclease activation following reversible focal ischemia in the rat brain
4. Protective effect of prostaglandin I(2) analogs on ischemic delayed neuronal damage in gerbils
5. Prostacyclin as a circulatory hormone
6. Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat
7. Induction of DNA fragmentation after 10-120 min of focal cerebral ischemia in rats
8. Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia
9. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats
10. Lack of effect of PN 200-110 on neuronal injury and neurological outcome in middle cerebral artery-occluded rats
11. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia
12. Prostacyclin infusion in acute cerebral infarction
13. L-Arginine decreases infarct size caused by middle cerebral arterial occlusion in SHR
14. Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion
15. CNS-specific prostacyclin ligands as neuronal survival-promoting factors in the brain
16. Calcium antagonists reduce the extent of infarction in rat middle cerebral artery occlusion model as determined by quantitative magnetic resonance imaging
17. Treatment of hypertension with isradipine reduces infarct size following stroke in laboratory animals
18. Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia
19. Effects of the calcium antagonist nilvadipine on focal cerebral ischemia in spontaneously hypertensive rats
20. (15R)-16-(m-tolyl)-17,18,19,20-tetranorisocarbacyclin: A stable ligand with high binding affinity and selectivity for a prostacyclin receptor in the central nervous system
21. 15-Deoxy-16-(m-tolyl)-17,18,19,20-tetranorisocarbacyclin: A simple TIC derivative with potent anti-apoptotic activity for neuronal cells
22. A semiautomated method for measuring brain infarct volume
23. Neuroprotective effects depend on the model of focal ischemia following middle cerebral artery occlusion
24. A novel subtype of the prostacyclin receptor expressed in the central nervous system
25. Focal cerebral ischaemia in the rat: 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion
26. Endonuclease activation following focal ischemic injury in the rat brain
27. A novel subtype of prostacyclin receptor in the central nervous system
28. Brain uptake of 11C-labeled stable prostacyclin receptor ligand studies by positron emission tomography
29. Pharmacokinetic and pharmacodynamic studies of (R)-8-hydroxy-2-(di-n-propylamino)tetralin in the rat