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Volumn 7, Issue 3, 1997, Pages 165-172

Pharmacokinetic and pharmacodynamic studies of (R)-8-hydroxy-2-(di-n- propylamino)tetralin in the rat

Author keywords

5 HT(1A) receptors; 8 OH DPAT; Brain; Drug concentration; Enantiomers; Rat

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 5 HYDROXYTRYPTOPHAN; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR;

EID: 0030975832     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(96)00395-1     Document Type: Article
Times cited : (41)

References (29)
  • 3
    • 0015440803 scopus 로고
    • Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in vivo using an inhibitor of the aromatic amino acid decarboxylase
    • Carlsson, A., Davis, J.N., Kehr, W., Lindqvist, M. and Atack, C.V. (1972) Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in vivo using an inhibitor of the aromatic amino acid decarboxylase. Naunyn-Schmiedeberg's Arch. Pharmacol. 275, 153-168.
    • (1972) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.275 , pp. 153-168
    • Carlsson, A.1    Davis, J.N.2    Kehr, W.3    Lindqvist, M.4    Atack, C.V.5
  • 5
    • 0028990742 scopus 로고
    • 1A receptor agonists: Recent developments and controversial issues
    • 1A receptor agonists: recent developments and controversial issues. Psychopharmacology 121, 1-26.
    • (1995) Psychopharmacology , vol.121 , pp. 1-26
    • De Vry, J.1
  • 9
    • 0020367109 scopus 로고
    • 8-Hydroxy-2-di-n-propylaminotetralin, 8-OHDPAT, a potent and selective simple ergot congener with 5-HT-receptor stimulating activity
    • Hjorth, S., Carlsson, A., Lindberg, P., Sanchez, D., Wikström, H., Arvidsson, L.E., Hacksell, U. and Nilsson, J.L.G. (1982) 8-Hydroxy-2-di-n-propylaminotetralin, 8-OHDPAT, a potent and selective simple ergot congener with 5-HT-receptor stimulating activity. J. Neural Transm. 55, 169-188.
    • (1982) J. Neural Transm. , vol.55 , pp. 169-188
    • Hjorth, S.1    Carlsson, A.2    Lindberg, P.3    Sanchez, D.4    Wikström, H.5    Arvidsson, L.E.6    Hacksell, U.7    Nilsson, J.L.G.8
  • 10
    • 0021956188 scopus 로고
    • Hypothermia in the rat induced by the potent serotoninergic agent 8-OH-DPAT
    • Hjorth, S. (1985) Hypothermia in the rat induced by the potent serotoninergic agent 8-OH-DPAT. J. Neural Transm. 61, 131-135.
    • (1985) J. Neural Transm. , vol.61 , pp. 131-135
    • Hjorth, S.1
  • 11
    • 0017086367 scopus 로고
    • An animal behaviour model for studying central serotonergic synapses
    • Jacobs, B.L. (1976) An animal behaviour model for studying central serotonergic synapses. Life Sci. 19, 777-786.
    • (1976) Life Sci. , vol.19 , pp. 777-786
    • Jacobs, B.L.1
  • 12
    • 0025234642 scopus 로고
    • The long-term effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on copulatory and exploratory behaviour in male rats
    • Johansson, C.E., Meyerson, B.J. and Höglund, A.U. (1990) The long-term effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on copulatory and exploratory behaviour in male rats. Eur. J. Pharmacol. 178, 1-9.
    • (1990) Eur. J. Pharmacol. , vol.178 , pp. 1-9
    • Johansson, C.E.1    Meyerson, B.J.2    Höglund, A.U.3
  • 13
    • 0000861818 scopus 로고
    • Improved preparation, chromatographic separation and X-ray crystallographic determination of the absolute configuration of the enantiomers of 8-hydroxy-2-(dipropylamino)tetralin (8-OH DPAT)
    • Karlsson, A., Pettersson, C., Sundell, S., Arvidsson, L.-E. and Hacksell, U. (1988) Improved preparation, chromatographic separation and X-ray crystallographic determination of the absolute configuration of the enantiomers of 8-hydroxy-2-(dipropylamino)tetralin (8-OH DPAT). Acta Chem. Scand. B42, 231-236.
    • (1988) Acta Chem. Scand. , vol.B42 , pp. 231-236
    • Karlsson, A.1    Pettersson, C.2    Sundell, S.3    Arvidsson, L.-E.4    Hacksell, U.5
  • 16
    • 0023872441 scopus 로고
    • Distribution coefficient, a convenient term for the relation of predictable physico-chemical properties to metabolic processes
    • Manners, C.N., Payling, D.W. and Smith, D.A. (1988) Distribution coefficient, a convenient term for the relation of predictable physico-chemical properties to metabolic processes. Xenobiotica 18, 331-350.
    • (1988) Xenobiotica , vol.18 , pp. 331-350
    • Manners, C.N.1    Payling, D.W.2    Smith, D.A.3
  • 17
    • 0029415119 scopus 로고
    • 1A agonist 8-hydroxy-2-(N,N-di-n-propylamino)tetralin (8-OH-DPAT) in the rat after intravenous and oral administration
    • 1A agonist 8-hydroxy-2-(N,N-di-n-propylamino)tetralin (8-OH-DPAT) in the rat after intravenous and oral administration. Xenobiotica 25, 1371-1380.
    • (1995) Xenobiotica , vol.25 , pp. 1371-1380
    • Mason, J.P.1    Dring, L.G.2    Caldwell, J.3
  • 18
    • 0023546796 scopus 로고
    • Serotonergic neuronal systems: What their anatomic organization tells us about function
    • Molliver, M.E. (1987) Serotonergic neuronal systems: what their anatomic organization tells us about function. J. Clin. Psychopharmacol. 7, 3S-23S.
    • (1987) J. Clin. Psychopharmacol. , vol.7
    • Molliver, M.E.1
  • 19
    • 0022003468 scopus 로고
    • The 5-HT syndrome and the drug discrimination paradigm in rats: Application in behavioral studies on the central 5-HT system
    • Ortmann, R. (1985) The 5-HT syndrome and the drug discrimination paradigm in rats: application in behavioral studies on the central 5-HT system. Pharmacopsychiatry 18, 198-201.
    • (1985) Pharmacopsychiatry , vol.18 , pp. 198-201
    • Ortmann, R.1
  • 20
    • 0017600519 scopus 로고
    • Transport of metabolic substrates through the blood-brain barrier
    • Pardridge, W.M. and Oldendorf, W.H. (1977) Transport of metabolic substrates through the blood-brain barrier. J. Neurochem. 28, 5-12.
    • (1977) J. Neurochem. , vol.28 , pp. 5-12
    • Pardridge, W.M.1    Oldendorf, W.H.2
  • 21
    • 0021485840 scopus 로고
    • Blood-brain barrier transport and brain sequestration of propranolol and lidocaine
    • Pardridge, W.M., Sakiyama, R. and Fierier, G. (1984) Blood-brain barrier transport and brain sequestration of propranolol and lidocaine. Am. J. Physiol. 247, R582-R588.
    • (1984) Am. J. Physiol. , vol.247
    • Pardridge, W.M.1    Sakiyama, R.2    Fierier, G.3
  • 22
    • 0022346190 scopus 로고
    • Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors
    • Pazos, A. and Palacios, J.M. (1985) Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res. 346, 205-230.
    • (1985) Brain Res. , vol.346 , pp. 205-230
    • Pazos, A.1    Palacios, J.M.2
  • 23
    • 0024462182 scopus 로고
    • Determination of brain concentrations of 8-hydroxy-2- (di-n-propylamino)tetralin by liquid chromatography with electrochemical detection
    • Perry, K.W. and Fuller, R.W. (1989) Determination of brain concentrations of 8-hydroxy-2- (di-n-propylamino)tetralin by liquid chromatography with electrochemical detection. Biochem. Pharmacol. 38, 3169-3173.
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 3169-3173
    • Perry, K.W.1    Fuller, R.W.2
  • 24
    • 0022544893 scopus 로고
    • The inhibition of the cage-leaving response: A model for studies of the serotonergic neurotransmission in the rat
    • Renyi, L., Archer, A., Minor, B.G., Tandberg, B., Fredriksson, A. and Ross, S.B. (1986) The inhibition of the cage-leaving response: a model for studies of the serotonergic neurotransmission in the rat. J. Neural Transm. 65, 193-210.
    • (1986) J. Neural Transm. , vol.65 , pp. 193-210
    • Renyi, L.1    Archer, A.2    Minor, B.G.3    Tandberg, B.4    Fredriksson, A.5    Ross, S.B.6
  • 25
    • 0027437721 scopus 로고
    • Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]- 2 -(di-n-propyl-amino)-tetralins and the formation of active metabolites in vivo
    • Sonesson, C., Boije, M., Svensson, K., Ekman, A., Carlsson, A., Romero, A.G., Martin, I.J., Duncan, J.N., King, L.J. and Wikström, H. (1993) Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]- 2 -(di-n-propyl-amino)-tetralins and the formation of active metabolites in vivo. J. Med. Chem. 36, 3409-3416.
    • (1993) J. Med. Chem. , vol.36 , pp. 3409-3416
    • Sonesson, C.1    Boije, M.2    Svensson, K.3    Ekman, A.4    Carlsson, A.5    Romero, A.G.6    Martin, I.J.7    Duncan, J.N.8    King, L.J.9    Wikström, H.10
  • 26
    • 0021678913 scopus 로고
    • The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat
    • Tricklebank, M.D., Forler, C. and Fozard, J.R. (1985) The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat. Eur. J. Pharmacol. 106, 271-282.
    • (1985) Eur. J. Pharmacol. , vol.106 , pp. 271-282
    • Tricklebank, M.D.1    Forler, C.2    Fozard, J.R.3
  • 27
    • 0023951984 scopus 로고
    • Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin
    • Wikström, H., Elebring, T., Hallnemo, G., Anderson, B., Svensson, K., Carlsson, A. and Rollema, H. (1988) Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. J. Med. Chem. 31, 1080-1084.
    • (1988) J. Med. Chem. , vol.31 , pp. 1080-1084
    • Wikström, H.1    Elebring, T.2    Hallnemo, G.3    Anderson, B.4    Svensson, K.5    Carlsson, A.6    Rollema, H.7
  • 29
    • 0029951557 scopus 로고    scopus 로고
    • Differential serotonergic and dopaminergic activities of the (R)- and (S)-enantiomers of 2-(di-n-propylamino)tetralin
    • Yu, H., Liu, Y., Malmberg, Å., Mohell, N., Hacksell, U. and Lewander, T. (1996) Differential serotonergic and dopaminergic activities of the (R)- and (S)-enantiomers of 2-(di-n-propylamino)tetralin. Eur. J. Pharmacol. 303, 151-162.
    • (1996) Eur. J. Pharmacol. , vol.303 , pp. 151-162
    • Yu, H.1    Liu, Y.2    Malmberg, Å.3    Mohell, N.4    Hacksell, U.5    Lewander, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.