Effect of acyl chain length and branching on the enantioselectivity of Candida rugosa lipase in the kinetic resolution of 4-(2-difluoromethoxyphenyl)-substituted 1,4-dihydropyridine 3,5-diesters

Journal of Organic Chemistry

Volumn 67, Issue 2, 2002, Pages 401-410

  Sobolev, Arkadij ^a,b   Franssen, Maurice C R ^a   Vigante, Brigita ^b   Cekavicus, Brigita ^b   Zhalubovskis, Raivis ^b   Kooijman, Huub ^c   Spek, Anthony L ^c   Duburs, Gunars ^b   De Groot, Aede ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ENANTIOSELECTIVITY;

BIOCATALYSTS; CATALYST SELECTIVITY; DERIVATIVES; HYDROLYSIS; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY;

ESTERS;

1,4 DIHYDROPYRIDINE DERIVATIVE; 3 [(ISOBUTYRYLOXY)METHYL] 5 METHYL 4 (2 DIFLUOROMETHOXYPHENYL) 2,6 DIMETHYL 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; 3 METHYL 5 (2 PROPOXYETHYL) 4 [2 (DIFLUOROMETHOXY)PHENYL] 2,6 DIMETHYL 1,4 DIHYDRO 3,5 PYRIDINEDICARBOXYLATE; 5 (2 PROPOXYETHYL) 4 [2 (DIFLUOROMETHOXY)PHENYL] 2,6 DIMETHYL 1,4 DIHYDRO 3,5 PYRIDINE DICARBOXYLATE; 5 METHYL 4 [2 (DIFLUOROMETHOXY)PHENYL] 2,6 DIMETHYL 1,4 DIHYDRO 3,5 PYRIDINEDICARBOXYLATE; CEREBROCRAST; DIISOPROPYL ETHER; ESTER DERIVATIVE; ETHER DERIVATIVE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ARTICLE; CANDIDA RUGOSA; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; HYDROLYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CANDIDA; CARBOXYLIC ACIDS; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; DIHYDROPYRIDINES; ESTERS; HYDROLASES; HYDROLYSIS; KINETICS; LIPASE; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 0037169114     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0104025     Document Type: Article

References (32)