Lipase-catalyzed enantioselective hydrolysis of bis(acyloxymethyl) 1,4- dihydro-3,5-pyridinedicarboxylates leading to optically active medicines

Chemical and Pharmaceutical Bulletin

Volumn 45, Issue 5, 1997, Pages 863-868

  Ebiike, Hirosato ^a   Maruyama, Kaori ^a   Yamazaki, Yukiyoshi ^a   Hirose, Yoshihiko ^b   Kariya, Kinya ^b   Sasaki, Ikuharu ^b   Kurono, Yoshiaki ^b   Terao, Yoshiyasu ^a   Achiwa, Kazuo ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b Amano Enzyme Inc   (Japan)

Author keywords

1,4 Dihydropyridine; Calcium antagonist; Lipase catalyzed reaction

Indexed keywords

1,4 DIHYDRO 2,4,6 TRIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID; 1,4 DIHYDRO 2,4,6 TRIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID METHYL 2 PHENYLTHIOETHYL ESTER; 4 ARYL 1,4 DIHYDRO 2,6 DIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID; DIHYDROPYRIDINE DERIVATIVE; FELODIPINE; NICARDIPINE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DRUG ACTIVITY; DRUG HYDROLYSIS; ENANTIOMER; STEREOCHEMISTRY;

EID: 0030950586     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.45.863     Document Type: Article

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