Cerebral Blood Flow, Vascular Response and Metabolism in Patients with MELAS Syndrome - Xenon CT and PET Study

Keio Journal of Medicine

Volumn 49, Issue , 2000, Pages A68-A76

  Nariai, Tadashi ^a   Ohno, Kikuo ^a   Akimoto, Hideaki ^a   Ohta, Yoshihisa ^a   Nagaoka, Tsukasa ^a   Hirakawa, Kimiyoshi ^a   Ishii, Kenji ^b   Senda, Michio ^b  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

acetazolamide; blood flow; glucose metabolism; MELAS; oxygen metabolism; xenon CT

Indexed keywords

ACETAZOLAMIDE; OXYGEN 15; XENON;

ADULT; BRAIN BLOOD FLOW; BRAIN OXYGEN CONSUMPTION; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; CONFERENCE PAPER; GLUCOSE METABOLISM; HUMAN; ISOTOPE LABELING; MALE; MELAS SYNDROME; POSITRON EMISSION TOMOGRAPHY; VASOMOTOR REFLEX;

ADULT; BLOOD GLUCOSE; CEREBROVASCULAR CIRCULATION; HUMANS; MALE; MELAS SYNDROME; OXYGEN; TOMOGRAPHY, EMISSION-COMPUTED; TOMOGRAPHY, X-RAY COMPUTED; XENON;

EID: 0034032519     PISSN: 00229717     EISSN: 18801293     Source Type: Journal    
DOI: 10.2302/kjm.49.supplement1_A68     Document Type: Article

References (13)

1. Pavlakis SG, Phillips PC, DiMauro S, et al: Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive clinical syndrome. Ann Neurol 1984; 16: 481-488
2. Gilchrist JM, Sikirica M, Stopa E, et al: Adult-onset MELAS. Evidence for involvement of neurons as well as cerebral vasculature in strokelike episodes. Stroke 1996; 27: 1420-1423
3. Sano M, Ishii K, Momosc Y, et al: Cerebral metabolism of oxygen and glucose in a patient with MELAS syndrome. Acta Neurol Scand 1995; 92: 497-502
4. Goto Y, Nonaka I, Horai S: A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies [see comments]. Nature 1990; 348: 651-653
5. Castillo M, Kwock L, Green C: MELAS syndrome: imaging and proton MR spectroscopic findings. AJNR Am J Neuroradiol 1995; 16: 233-239
6. Mathews PM, Andermann F, Silver K, et al: Proton MR spectroscopic characterization of differences in regional brain metabolic abnormalities in mitochondrial encephalomyopathies. Neurology 1993; 43: 2484-2490
7. Takahashi S, Tohgi II, Yonezawa II, et al: Cerebral blood flow and oxygen metabolism before and after a stroke- like episode in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). J Neurol Sci 1998; 158: 58-64
8. Frackowiak RS, Herold S, Petty RK, et al: The cerebral metabolism of glucose and oxygen measured with positron tomography in patients with mitochondrial diseases. Brain 1988; 111: 1009-1024
9. Gropen TI, Prohovnik I, Tatemichi TK, et al: Cerebral hyperemia in MELAS. Stroke 1994; 25: 1873-1876
10. Miyamoto A, Oki J, Takahashi S, et al: Serial imaging in MELAS. Neuroradiology 1997; 39: 427-430
11. Ooiwa Y, Uematsu Y, Terada T, et al: Cerebral blood flow in mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes. Stroke 1993; 24: 304-309
12. Satoh M, Ishikawa N, Yoshizawa T, et al: N-isopropyl-p-[123I]iodoamphetamine SPECT in MELAS syndrome: comparison with CT and MR imaging. J Comput Assist Tomogr 1991; 15: 77-82
13. Watanabe Y, Hashikawa K, Moriwaki H, et al: SPECT findings in mitochondrial encephalomyopathy. J Nucl Med 1998; 39: 961-964