Phosphatidylinositol 3-kinase mediates inhibitory effect of angiotensin II on sodium/glucose cotransporter in renal epithelial cells

Life Sciences

Volumn 71, Issue 1, 2002, Pages 1-13

  Kawano, Kazuya ^a   Ikari, Akira ^a   Nakano, Mika ^a   Suketa, Yasunobu ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Angiotensin II; cAMP; LLC PK1 cells; PI 3 kinase; SGLT1; Translocation

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 8 BROMO CYCLIC AMP; ALPHA METHYLGLUCOSIDE; ANGIOTENSIN; CARBON 14; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN; SODIUM GLUCOSE COTRANSPORTER 1; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; CARBOHYDRATE TRANSPORT; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INACTIVATION; KIDNEY CELL; KIDNEY EPITHELIUM; KIDNEY TUBULE EPITHELIUM; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TISSUE LEVEL; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANALYSIS OF VARIANCE; ANGIOTENSIN II; ANIMALS; BLOTTING, WESTERN; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; KIDNEY; KINETICS; LLC-PK1 CELLS; MEMBRANE GLYCOPROTEINS; MICROVILLI; MONOSACCHARIDE TRANSPORT PROTEINS; SODIUM-GLUCOSE TRANSPORTER 1; SWINE;

EID: 0037165873     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)01573-4     Document Type: Article

References (42)

1. +-glucose transporter inhibitor, improves hyperglycemia in streptozotocin-induced diabetic rats
2. +-independent D-glucose transport in rabbit renal basolateral membranes
3. Glucose transport in the kidney
4. Glucose transporters in the regulation of intestinal, renal, and liver glucose fluxes
5. Tissue targeting of angiotensin peptides
6. Blood, pituitary, and brain renin-angiotensin systems and regulation of secretion of anterior pituitary gland
7. Reproduction and the renin-angiotensin system
8. Tissue renin-angiotensin systems. Their role in cardiovascular disease
9. Hemodynamic theory of progressive renal disease: A 10-year update in brief review
10. + antiport in rat proximal tubule NaCl absorption
11. Differences in active and passive glucose transport along the proximal nephron
12. Organic solutes in fluid absorption by renal proximal convoluted tubules
13. + transport
14. +/glucose cotransporter expression by protein kinases in Xenopus laevis oocytes
15. Mechanism of beta-adrenergic agonist-induced transmural transport of glucose in rat small intestine. Regulation of phosphorylation of SGLT1 controls the function
16. +/glucose cotransporter by insulin
17. Upregulation of SGLT-1 transport activity in rat jejunum induced by GLP - 2 infusion in vivo
18. 1 cells. Increased message stability after cyclic AMP elevation or differentiation inducer treatment
19. Heterogeneity of sodium-dependent D-glucose transport sites along the proximal tubule: Evidence from vesicle studies
20. The origin and characteristics of a pig kidney cell strain, LLC-PK
21. Role of the PI3K/PKB signaling pathway in cAMP-mediated translocation of rat liver Ntcp
22. Platelet-derived growth factor stimulates sodium-dependent Pi transport in osteoblastic cells via phospholipase Cgamma and phosphatidylinositol 3′ -kinase
23. 1/PKE20 cells: II. Hormonal regulation
24. - cotransport in the rabbit proximal tubule
25. + exchange in proximal tubule cells
26. Dose-dependent stimulation and inhibition of proximal tubular sodium reabsorption by angiotensin II in the rat kidney
27. +-ATPase: A final common pathway for regulation of natriuresis
28. +/glucose cotransporter
29. 1 cells
30. A cell strain cultured from porcine kidney increases cyclic AMP content upon exposure to calcitonin or vasopressin
31. 1). The basolateral systems
32. 1). The apical systems
33. +/glucose cotransporter
34. +-dependent sugar transport in a cultured epithelial cell line from pig kidney
35. +/glucose cotransporter SGLT2 reveal a common mechanism for SGLT1 and SGLT2
36. +-dependent hexose transport in vesicles from cultured renal epithelial cell line
37. Insulin-induced actin filament remodeling colocalizes actin with phosphatidylinositol 3-kinase and GLUT4 in L6 myotubes
38. The insulin signaling system
39. Tyrosine phosphorylation of specific protein kinase C isoenzymes participates in insulin stimulation of glucose transport in primary cultures of rat skeletal muscle
40. Molecular cloning and characterization of an insulin-regulatable glucose transporter
41. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses
42. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)