Antisense epidermal growth factor receptor RNA transfection in human glioblastoma cells down-regulates telomerase activity and telomere length

British Journal of Cancer

Volumn 86, Issue 8, 2002, Pages 1328-1332

  Tian, X X ^a   Pang, J C S ^b   Zheng, J ^a   Chen, J ^c   To, S S T ^d   Ng, H K ^b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^d HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Antisense; Epidermal growth factor receptor; Glioblastoma; Telomerase

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN P53; TELOMERASE;

ARTICLE; CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CARCINOGENICITY; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; GENE AMPLIFICATION; GENE OVEREXPRESSION; GLIOBLASTOMA; HUMAN; HUMAN CELL; LONG TERMINAL REPEAT; PRIORITY JOURNAL; PROTEIN EXPRESSION; TELOMERE;

ANIMALS; BLOTTING, SOUTHERN; DOWN-REGULATION; GLIOBLASTOMA; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, ANTISENSE; RNA, MESSENGER; TELOMERASE; TELOMERE; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0037156960     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600244     Document Type: Article

References (22)

1. Telomerase expression in gliomas including the nonastrocytic tumors
2. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
3. Telomeres, telomerase and cancer: An up-date
4. Inhibition of telomerase limits the growth of human cancer cells
5. Growth-related signaling regulates activation of telomerase in regenerating hepatocyes
6. Expression of telomerase-associated genes: Reflection of telomerase activity in gastric cancer?
7. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit
8. EGF receptor in neoplasia and metastasis
9. Decrease in telomerase activity in U87MG human glioblastomas after treatment with an antagonist of growth hormone-releasing hormone
10. Telomerase activity in a specific cell subset co-expressing integrin beta1/EGFR but not p75NGFR/bcl-2/integrin beta4 in normal human epithelial cells
11. Telomerase is controlled by protein kinase C alpha in human breast cancer cells
12. Cutting edge: Telomerase activity in human T lymophocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation
13. Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
14. Inhibition of telomerase activity and cell proliferation by a reverse transcriptase inhibitor in gynaecological cancer cell lines
15. The molecular genetics of central nervous system tumors
16. Inhibitory effect of antisense epidermal growth factor receptor RNA on the proliferation of rat C6 glioma cells in vitro and in vivo
17. The autocrine loop of TGF-α/EGFR and brain tumors
18. Altered expression of the suppressors PML and p53 in glioblastoma cells with the antisense-EGF-receptor
19. Antisense epidermal growth factor receptor RNA transfection in human malignant glioma cells leads to inhibition of proliferation and induction of differentiation
20. Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium
21. Direct activation of TERT transcription by c-MYC
22. The neurotrophic action and signaling of epidermal growth factor