Design, synthesis, and tripeptidyl peptidase II inhibitory activity of a novel series of (S)-2,3-dihydro-2-(4-alkyl-1H-imidazol-2-yl)-1H-indoles

Journal of Medicinal Chemistry

Volumn 45, Issue 24, 2002, Pages 5303-5310

  Breslin, Henry J ^a   Miskowski, Tamara A ^a   Kukla, Michael J ^a   Leister, William H ^a   De Winter, Hans L ^b   Gauthier, Diane A ^a   Somers, Maria V F ^b   Peeters, Daniëlle C G ^b   Roevens, Peter W M ^b  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b NONE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 AMINO 1 OXOBUTYL) N BUTYL 2,3 DIHYDRO 1H INDOLE 2 CARBOXAMIDE; INDOLE DERIVATIVE; PEPTIDASE II INHIBITOR; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE;

ENZYME INHIBITORS; IMIDAZOLES; INDOLES; MODELS, MOLECULAR; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037153232     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0202831     Document Type: Article

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