Albumin affinity tags increase peptide half-life in vivo

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 20, 2002, Pages 2883-2886

  Koehler, Michael F T ^a   Zobel, Kerry ^a   Beresini, Maureen H ^a   Caris, Lisa D ^a   Combs, Daniel ^a   Paasch, Brian D ^a,b   Lazarus, Robert A ^a  

^a GENENTECH INC   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT PROTEIN; PEPTIDE DERIVATIVE; PEPTIDE LIBRARY; SERUM ALBUMIN; TETRAPEPTIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; NONHUMAN; PLASMA HALF LIFE; PROTEIN BINDING; RABBIT;

AFFINITY LABELS; ALBUMINS; ANIMALS; ANTICOAGULANTS; CHROMATOGRAPHY, LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; FACTOR VIIA; HALF-LIFE; HUMANS; PEPTIDES; PROTEIN BINDING; RABBITS; SPECTROPHOTOMETRY, ULTRAVIOLET;

ORYCTOLAGUS CUNICULUS;

EID: 0037152451     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00610-8     Document Type: Article

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