Molecular modelling of lanosterol 14α-demethylase (CYP51) from Saccharomyces cerevisiae via homology with CYP102, a unique bacterial cytochrome P450 isoform: Quantitative structure-activity relationships (QSARs) within two related series of antifungal azole derivatives

Journal of Enzyme Inhibition

Volumn 14, Issue 3, 1999, Pages 175-192

  Lewis, David F V ^a   Wiseman, Alan ^a   Tarbit, Mike H ^b  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

14 demethylase; Antifungals; Azole derivatives; CYP102; CYP51; Inhibitors; Lanosterol; QSAR

Indexed keywords

ANTIFUNGAL AGENT; CARBON 14; CYTOCHROME P450; HEMOPROTEIN; KETOCONAZOLE; LANOSTEROL DERIVATIVE; PYRROLE DERIVATIVE;

ANTIFUNGAL ACTIVITY; ARTICLE; BACILLUS MEGATERIUM; BINDING SITE; CRYSTAL STRUCTURE; DEMETHYLATION; ELECTRIC POTENTIAL; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR MODEL; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

BACILLUS MEGATERIUM; BACTERIA (MICROORGANISMS); SACCHAROMYCES CEREVISIAE;

EID: 0033067397     PISSN: 87555093     EISSN: None     Source Type: Journal    
DOI: 10.3109/14756369909030315     Document Type: Article

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