Genotoxicity of idarubicin and its modulation by vitamins C and E and amifostine

Chemico-Biological Interactions

Volumn 140, Issue 1, 2002, Pages 1-18

  Błasiak, Janusz ^a   Gloc, Ewa ^a   Woźniak, Katarzyna ^a   Młynarski, Wojciech ^b   Stolarska, Małgorzata ^b   Skórski, Tomasz ^c   Majsterek, Ireneusz ^a  

^a UNIVERSITY OF LODZ   (Poland)

^b MEDICAL UNIVERSITY OF LODZ   (Poland)

^c Temple University   (United States)

Author keywords

Amifostine; Chronic myelogenous leukaemia; Comet assay; DNA damage; DNA methylation; DNA repair; Free radicals; Idarubicin; Oxidative DNA damage; Spin traps; Vitamin C; Vitamin E

Indexed keywords

3 METHYLADENINE; ALPHA TOCOPHEROL; AMIFOSTINE; ASCORBIC ACID; DNA GLYCOSYLTRANSFERASE; ENDONUCLEASE; FREE RADICAL; IDARUBICIN; N TERT BUTYL ALPHA (4 PYRIDYL 1 OXIDE) NITRONE; N TERT BUTYL ALPHA PHENYLNITRONE; PYRIMIDINE DERIVATIVE; REACTIVE OXYGEN METABOLITE;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; B LYMPHOCYTE; CANCER CELL; CARDIOTOXICITY; CELL PROTECTION; CELL TRANSFORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA METHYLATION; DRUG RESPONSE; GENOTOXICITY; HUMAN; HUMAN CELL; LYMPHOCYTE; METASTASIS; MOUSE; NONHUMAN; ONCOGENE; SHORT SURVEY;

ADULT; AMIFOSTINE; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIOXIDANTS; ASCORBIC ACID; CELL LINE, TRANSFORMED; CELL SURVIVAL; COMET ASSAY; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDODEOXYRIBONUCLEASES; HUMANS; IDARUBICIN; LYMPHOCYTES; MALE; MICE; MUTAGENS; TUMOR CELLS, CULTURED; VITAMIN E; VITAMINS;

MURINAE;

EID: 0037140386     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(02)00012-1     Document Type: Short Survey

References (43)

1. The origin of DNA breaks: A consequence of DNA damage, DNA repair or apoptosis
2. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
3. Clinical applications of anticancer drugs targeted to topoisomerase II
4. Idarubicin: A brief overview on pharmacology and clinical use
5. Molecular basis of anthracycline-induced cardiotoxicity and its prevention
6. Vitamin C suppresses the cisplatin toxicity on blood platelets
7. Effects of high doses of vitamin C and E against doxorubicin-induced chromosomal damage in Wistar rat bone marrow cell
8. Modulatory effects of melatonin and vitamin E on doxorubicin-induced cardiotoxicity in Ehrlich ascites carcinoma-bearing mice
9. A phase I trial of topical topitriol (calcitriol, 1,25-dihydroxyvitamin D3) to prevent chemotherapy-induced alopecia
10. Vitamin C: Antioxidant or pro-oxidant in vivo?
11. The effects of iron and vitamin C co-supplementation on oxidative damage to DNA in healthy volunteers
12. Novel repair action of vitamin C upon in vivo oxidative DNA damage
13. Does vitamin C act as a pro-oxidant under physiological conditions?
14. Lipid peroxidation in neural tissues and fractions from vitamin E deficient rats
15. Quenching of reactive oxidative species by probucol and comparison with other antioxidants
16. α-tocopherol induces oxidative damage to DNA in the presence of copper(II) ions
17. Amifostine: The preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies
18. Amifostine: Mechanisms of action underlying cytoprotection and chemoprevention
19. Anticancer drug-induced kidney disorders
20. Amifostine (WR-2721) selective protection against melphalan genotoxicity
21. Chemoprotective and radioprotective effects of amifostine: An update of clinical trials
22. Direct enzymatic detection of endogenous base damage in human lymphocyte DNA
23. Clustered DNA damage, influence on damage excision by XRS5 nuclear extracts and Escherichia coli Nth and Fpg proteins
24. Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): Excision of purine lesions in DNA produced by ionizing radiation or photosensitization
25. 8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity
26. Two enzymes are required for strand incision in repair of alkylated DNA
27. Activity of Escherichia coli DNA-glycosylases on DNA damaged by methylating and ethylating agents and influence of 3-substituted adenine derivatives
28. Spin trapping of precursors of thymine damage in X-irradiated DNA
29. Protein tyrosine kinase and cancer
30. The molecular biology of chronic myeloid leukemia
31. Chronic myelogenous leukemia as gene activation model in oncology
32. A simple technique for quantitation of low levels of DNA damage in individual cells
33. The comet assay: Mechanisms and technical considerations
34. A comparison of the in vitro genotoxicity of tri- and hexavalent chromium
35. The single cell gel electrophoresis assay for induced DNA damage (comet assay): Measurement of tail length and moment
36. Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing
37. Relationship between lethal effects and topoisomerase II-mediated double-stranded DNA breaks produced by anthracyclines with different sequence specificity
38. Adriamycin: The role of lipid peroxidation in cardiac toxicity and tumor response
39. Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species
40. Adriamycin-dependent release of iron from microsomal membranes
41. A highly conserved endonuclease activity present in Escherichia coli, bovine, and human cells recognizes oxidative DNA damage at sites of pyrimidines
42. Amifostine differentially modulates DNA damage evoked by idarubicin in normal and leukemic cells
43. Effect of antioxidant vitamin supplementation on DNA damage and repair in human lymphoblastoid cells