Organization and regulation of the human rasGAP gene

Gene

Volumn 285, Issue 1-2, 2002, Pages 149-156

  Glanzer, Jason G ^a   Liao, Lixin ^a   Baker, Tammy ^a   McMullen, Mary H ^a   Langan, Amy S ^a   Crandall, Lisa Z ^a   Vorce, Roseann L ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b PFIZER INC   (United States)

Author keywords

5 UTR; CpG island; Expression; Genomic; Promoter; rasGAP; TATA less

Indexed keywords

ALKALINE PHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RNA LIGASE; TRANSCRIPTION FACTOR;

5' UNTRANSLATED REGION; ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA FLANKING REGION; EXON; FETUS; GENE AMPLIFICATION; GENE DELETION; GENE SEQUENCE; GENETIC ORGANIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRON; MOLECULAR SIZE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; RNA SPLICING; SEQUENCE ANALYSIS; TISSUE TYPES; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ALKALINE PHOSPHATASE; BASE SEQUENCE; CPG ISLANDS; DNA; EXONS; FEMALE; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES; HELA CELLS; HUMANS; INTRONS; MALE; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); RAS GTPASE-ACTIVATING PROTEINS; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION INITIATION SITE; TRANSFECTION;

MAMMALIA;

EID: 0037138372     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(02)00415-8     Document Type: Article

References (41)

1. The ribosome scanning model for translation initiation: Implications for gene prediction and full-length cDNA detection
2. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
3. PDGF2/c-sis mRNA leader contains a differentiation-linked internal ribosomal entry site (D-IRES)
4. The polypyrimidine tract binding (PTB) protein interacts with single-stranded DNA in a sequence-specific manner
5. Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras
6. Oligodeoxyribonucleotide length and sequence effects on intramolecular and intermolecular G-quartet formation
7. Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family
8. Intron-exon structures of eukaryotic model organisms
9. p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly
10. CpG islands in vertebrate genomes
11. Purification, characterization, and Western blot analysis of human GTPase-activating protein from native and recombinant sources
12. Promoter prediction in the human genome
13. Identification of neurofibromatosis type I gene product as an insoluble GTPase-activating protein toward ras p21
14. Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein
15. An analysis of 5′-non-coding sequences from 699 vertebrate messenger RNAs
16. Role of p120 Ras-GAP in directed cell movement
17. Genomic organization of the neurofibromatosis 1 gene (NF1)
18. cDNA cloning and chromosomal mapping of a novel human GAP (GAP1M), a GTPase-activating protein of Ras
19. Use of an alternate splice donor site in the human GAP gene is responsible for synthesis of the p100 isoform
20. Determinants of species- and placenta-specific expression of p100 GAP
21. A family of novel DNA-binding nuclear proteins having polypyrimidine tract-binding motif and arginine/serine-rich motif
22. Following G-quartet formation by UV-spectroscopy
23. Species specificity and organ, cellular and subcellular localization of the 100 kDa ras GTPase activating protein
24. The CpG island promoter of the human proopiomelanocortin gene is methylated in non-expressing normal tissue and tumors and represses expression
25. Structural and compositional features of untranslated regions of eukaryotic mRNAs
26. A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing
27. MatInd and MatInspector - New fast and versatile tools for detection of consensus matches in nucleotide sequence data
28. The TATA-less, GC-rich porcine dipeptidylase IV (DPPIV) promoter shows bidirectional activity
29. EMBOSS: The European Molecular Biology Open Software Suite
30. DNA tetraplex formation in the control region of c-myc
31. Transcriptional silencing of Cyclooxygenase-2 by hyper-methylation of the 5′ CpG island in human gastric carcinoma cells
32. Decreased expression of Ras GTPase activating protein in human trophoblastic tumors
33. C-Myc 5′ untranslated region contains an internal ribosome entry segment
34. A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants
35. Molecular cloning of two types of GAP complementary DNA from human placenta
36. Compensatory modulation of GAP activity in response to oncogenic stimulation
37. Mapping of 386 kb of genomic DNA in the human dystrophin-encoding gene (DYS) using an ordered phage lambda sublibrary of a YAC clone containing the DYS region
38. A CT repeat in the promoter of the chicken malic enzyme gene is essential for function at an alternative transcription start site
39. Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein
40. Purification, characterization, and cellular localization of the 100-kDa human placental GTPase-activating protein