Viral evolution and challenges in the development of HIV vaccines

Vaccine

Volumn 20, Issue SUPPL. 4, 2002, Pages

  Barouch, Dan H ^a   Letvin, Norman L ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

CTL; Escape; HIV

Indexed keywords

EPITOPE; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE;

ANIMAL MODEL; ANTIGEN RECOGNITION; CELL SPECIFICITY; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DISEASE COURSE; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOREACTIVITY; INFECTION CONTROL; INFECTION PREVENTION; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SHORT COURSE THERAPY; SIMIAN IMMUNODEFICIENCY VIRUS; TREATMENT FAILURE; VIRUS MUTANT; VIRUS MUTATION; VIRUS REPLICATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOLOGY; PHYSIOLOGY; REVIEW;

AIDS VACCINES; HIV; HUMANS; T-LYMPHOCYTES, CYTOTOXIC; VIRUS REPLICATION;

EID: 0037137536     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(02)00390-0     Document Type: Conference Paper

References (15)

1. Musey L., Hughes J., Schacker T., Shea T., Corey L., McElrath M.J. Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection. N. Engl. J. Med. 337:1997;1267-1274.
2. + lymphocytes. Science. 283:1999;857-860.
3. Barouch D.H., Santra S., Schmitz J.E.et al. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science. 290:2000;486-492.
4. Amara R.R., Villinger F., Altman J.D.et al. Control of a mucosal challenge and prevention of clinical AIDS in rhesus monkeys by a multiprotein DNA/MVA vaccine. Science. 292:2001;69-74.
5. Shiver J.W., Fu T.M., Chen L.et al. Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature. 415:2002;331-335.
6. Mellors J.W., Rinaldo C.R. Jr., Gupta P., White R.M., Todd J.A., Kingsley L.A. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science. 272:1996;1167-1170.
7. Quinn T.C., Wawer M.J., Sewankambo N.et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1n. N. Engl. J. Med. 342:2000;921-929.
8. Letvin N.L., Barouch D.H., Montefiori D.C. Prospects for vaccine protection against HIV-1 infection and AIDS. Annu. Rev. Immunol. 20:2002;73-99.
9. Barouch D.H., Kunstman J., Kuroda M.J.et al. Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes. Nature. 415:2002;335-339.
10. Phillips R.E., Rowland-Jones S., Nixon D.F.et al. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature. 354:1991;453-459.
11. Price D.A., Goulder P.J., Klenerman P.et al. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc. Natl. Acad. Sci. U.S.A. 94:1997;1890-1895.
12. Goulder P.J., Brander C., Tang Y.et al. Evolution and transmission of stable CTL escape mutations in HIV infection. Nature. 412:2001;334-338.
13. Evans D.T., O'Connor D.H., Jing P.et al. Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef. Nat. Med. 5:1999;1270-1276.
14. Allen T.M., O'Connor D.H., Jing P.et al. Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viremia. Nature. 407:2000;386-390.
15. O'Connor D.H., Allen T.M., Vogel T.U.et al. Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection. Nat. Med. 8:2002;493-499.