Hox proteins: Sculpting body parts by activating localised cell death

Current Biology

Volumn 12, Issue 22, 2002, Pages

  Alonso, Claudio R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; DROSOPHILA; HEXAPODA; INSECTA;

EID: 0037137421     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)01291-5     Document Type: Review

References (20)

1. Akam, M. (1998). Hox genes, homeosis and the evolution of segment identity: No need for hopeless monsters. Int. J. Dev. Biol. 42, 445-451.
2. Pavlopoulos, A. and Averof, M. (2002). Developmental evolution: Hox proteins ring the changes. Curr. Biol. 12, R291-293.
3. Lohmann, I., McGinnis, N., Bodmer, M. and McGinnis, W. (2002). The Drosophila Hox gene deformed sculpts head morphology via direct regulation of the Apoptosis activator reaper. Cell 110, 457.
4. Garcia-Bellido, A. (1975). Genetic control of wing disc development in Drosophila. Ciba Found. Symp. 0, 161-182.
5. Ekker, S.C., Jackson, D.G., von Kessler, D.P., Sun, B.I., Young, K.E. and Beachy, P.A. (1994). The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins. EMBO J. 13, 3551-3560.
6. Capovilla, M., Brandt, M. and Botas, J. (1994). Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis. Cell 76, 461-475.
7. Gould, A.P. and White, R.A. (1992). Connectin, a target of homeotic gene control in Drosophila. Development 116, 1163-1174.
8. Vachon, G., Cohen, B., Pfeifle, C., McGuffin, M.E., Botas, J. and Cohen, S.M. (1992). Homeotic genes of the Bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less. Cell 71, 437-450.
9. O'Hara, E., Cohen, B., Cohen, S.M. and McGinnis, W. (1993). Distal-less is a downstream gene of Deformed required for ventral maxillary identity. Development 117, 847-856.
10. Hu, N. and Castelli-Gair, J. (1999). Study of the posterior spiracles of Drosophila as a model to understand the genetic and cellular mechanisms controlling morphogenesis. Dev. Biol. 214, 197-210.
11. Graba, Y., Aragnol, D. and Pradel, J. (1997). Drosophila Hox complex downstream targets and the function of homeotic genes. Bioessays 19, 379-388.
12. Pradel, J. and White, R.A. (1998). From selectors to realizators. Int. J. Dev. Biol. 42, 417-421.
13. Edelman G.M. (1988). Topobiology: An Introduction to Molecular Embryology. (New York: Basic Books Inc).
14. Ganan, Y., Macias, D., Basco, R.D., Merino, R. and Hude, J.M. (1998). Morphological diversity of the avian foot is related with the pattern of msx gene expression in the developing autopod. Dev. Biol. 196, 33-41.
15. Stadler, H.S., Higgins, K.M. and Capecchi, M.R. (2001). Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs. Development 128, 4177-4188.
16. Sommer, R.J., Eizinger, A., Lee, K.Z., Jungblut, B., Bubeck, A. and Schlak, I. (1998). The Pristionchus HOX gene Ppa-lin-39 inhibits programmed cell death to specify the vulva equivalence group and is not required during vulval induction. Development 125, 3865-3873.
17. Plaza, S., Prince, F., Jaeger, J., Kloter, U., Flister, S., Benassayag, C., Cribbs, D. and Gehring, W.J. (2001). Molecular basis for the inhibition of Drosophila eye development by Antennapedia. EMBO J. 20, 802-811.
18. Raman, V., Martensen, S.A., Reisman, D., Evron, E., Odenwald, W.F., Jaffee, E., Marks, J. and Sukumar, S. (2000). Compromised HOXA5 function can limit p53 expression in human breast tumours. Nature 405, 974-978.
19. White, K., Grether, M.E., Abrams, J.M., Young, L., Farrell, K. and Steller, H. (1994). Genetic control of programmed cell death in Drosophila. Science 264, 677-683.
20. Sanchez-Herrero, E., Vernos, I., Marco, R. and Morata, G. (1985). Genetic organization of Drosophila bithorax complex. Nature 313, 108-113.