Papaverine induces apoptosis in vascular endothelial and smooth muscle cells

Life Sciences

Volumn 70, Issue 22, 2002, Pages 2675-2685

  Gao, Y J ^a   Stead, S ^a   Lee, R M K W ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Apoptosis; Endothelial cells; Papaverine; Smooth muscle cells

Indexed keywords

PAPAVERINE; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL TISSUE; AORTA MEDIA; APOPTOSIS; ARTERY MUSCLE; ARTICLE; CELL NUCLEUS; CELL STRUCTURE; CHROMATIN CONDENSATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY; ENDOTHELIUM CELL; NICK END LABELING; NONHUMAN; PH; RAT; SMOOTH MUSCLE FIBER; SWINE; VASCULAR ENDOTHELIUM;

ANIMALS; AORTA, THORACIC; APOPTOSIS; ARTERIES; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; IN SITU NICK-END LABELING; MUSCLE, SMOOTH, VASCULAR; PAPAVERINE; RATS; RATS, INBRED WKY; SODIUM CHLORIDE; SWINE; VASODILATOR AGENTS;

SUIDAE;

EID: 0037134257     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)01525-4     Document Type: Article

References (46)

1. Improvement of cerebral oxygenation patterns and metabolic validation of superselective intraarterial infusion of papaverine for the treatment of cerebral vasospasm
2. Effectiveness of intra-arterially infused papaverine solutions of various concentrations for the treatment of cerebral vasospasm
3. Superselective intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage
4. Intraluminal papaverine with pH 3 doubles blood flow in the internal mammary artery
5. Dilation of the internal mammary artery by external and intraluminal papaverine application
6. Paradoxical aggravation of vasospasm with papaverine infusion following aneurysmal subarachnoid hemorrhage. Case report
7. Complications associated with intraarterial administration of papaverine for vasospasm following subarachnoid hemorrhage. Two case reports
8. The effects of papaverine on phorbol dibutyrate-induced vasoconstriction in brain slice microvessels
9. Effects of hydrogen peroxide on pig coronary artery endothelium
10. Papaverine solutions cause loss of viability of endothelial cells
11. Papaverive abolishes endothelium-dependent dilatation of human internal mammary arteries in vitro
12. Intraarterial infusion of high-concentration papaverine damages cerebral arteries in rats
13. Papaverine injures the endothelium of the internal mammary artery
14. Programmed cell death and animal development
15. Programmed cell death during animal development
16. Apoptosis: An overview
17. Caspase-mediated proteolytic activation of calcineurin in thapsigargin-mediated apoptosis in SH-SY5Y neuroblastoma cells
18. Signal transduction of thapsigargin-induced apoptosis in osteoblast
19. Nifedipine induces apoptosis in cultured vascular smooth muscle cells from spontaneously hypertensive rats
20. 2+ pump in endothelium: Implications to coronary artery function
21. SERCA pump isoform expression in endothelium of veins and arteries: Every endothelium is not the same
22. Effects of peroxide on endothelial nitric oxide synthase in coronary arteries
23. Alterations in beta-adrenoceptors and polyploidy in cultured aortic smooth muscle cells from different age groups of spontaneously hypertensive rats and Wistar-Kyoto rats
24. Contraction and relaxation of human internal mammary artery after intraluminal administration of papaverine
25. Overcoming perioperative spasm of the internal mammary artery: Which is the best vasodilator?
26. Preparation of the internal mammary artery graft with intraluminal papaverine
27. Alkaline conditions accelerate polymorphonuclear leukocyte apoptosis in vitro
28. Acidosis induces necrosis and apoptosis of cultured hippocampal neurons
29. Acidic environment causes apoptosis by increasing caspase activity
30. Acidosis inhibits endothelial cell apoptosis and function and induces basic fibroblast growth factor and vascular endothelial growth factor expression
31. Neutrophil membrane potential changes and homotypic aggregation kinetics are pH dependent: Studies of chronic granulomatous disease
32. Cyclic nucleotide phosphodiesterases: Functional implication of multiple isoforms
33. Apoptosis of vascular smooth muscle cells. Protein kinase C and oncoprotein Bcl-2 are involved in regulation of apoptosis in non-transformed rat vascular smooth muscle cells
34. Apoptosis in target organs of hypertension
35. Signal transduction pathways in apoptosis
36. Activation of the cAMP signaling pathway increases apoptosis in human B-precursor cells and is associated with downregulation of Mcl-1 expression
37. 45Ca ion in subcellular fractions of dog biliary muscles
38. Role of calcium in the programmed death of rat prostatic glandular cells
39. Calcium chelators induce apoptosis - Evidence that raised intracellular ionised calcium is not essential for apoptosis
40. Neurotoxic effects of papaverine, tetrahydropapaverine and dimethoxyphenylethylamine on dopaminergic neurons in ventral mesencephalic-striatal co-culture
41. Effect of dopamine, dimethoxyphenylethylamine, papaverine, and related compounds on mitochondrial respiration and complex I activity
42. Papaverine: A potent inhibitor of respiration of C-6 astrocytoma cells
43. Mitochondria and apoptosis
44. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
45. Pulse pressure, aortic activity, and endothelium dysfunction in old hypertensive rats
46. Endothelium-derived prostanoids reduce 5-hydroxytryptamine-induced contraction in human uterine artery