Neurotoxic effects of papaverine, tetrahydropapaverine and dimethoxyphenylethylamine on dopaminergic neurons in ventral mesencephalic-striatal co-culture

Brain Research

Volumn 754, Issue 1-2, 1997, Pages 260-268

  Goto, Keigo ^a   Mochizuki, Hideki ^a   Hattori, Tastuya ^a   Nakamura, Noriyuki ^a   Mizuno, Yoshikuni ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

1 methyl 4 phenylpyridinium ion (MPP+); dimethoxyphenylethylamine EA); papaverine; Parkinson's disease; tetrahydropapaverine; ventral mesencephalic striatal co culture

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE DERIVATIVE; HOMOVERATRYLAMINE; PAPAVERINE; TETRAHYDROPAPAVERINE; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; EMBRYO; IMMUNOCYTOCHEMISTRY; MESENCEPHALON; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; BIOLOGICAL MARKERS; CELL SURVIVAL; COCULTURE TECHNIQUES; CORPUS STRIATUM; DIMETHOXYPHENYLETHYLAMINE; EMBRYO; ISOQUINOLINES; MESENCEPHALON; NEURONS; NEUROTOXINS; PAPAVERINE; RATS; TYROSINE 3-MONOOXYGENASE;

EID: 0030894408     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00093-0     Document Type: Article

References (46)

1. Albores, R., Neasfsey, E.J., Durker, G., Fields, J.Z. and Collins, M.A., Mitochondrial respiratory inhibition by N-methylated beta-carboline derivatives structurally resembling N-methyl-4-phenylpryridine, Proc. Natl. Acad. Sci. USA, 87 (1990) 9368-9372.
2. Barbeau, A., De Groot, J.A., Joly, J.G. Tremblay, D.R. and Donaldson, J., Urinary excretion of a 3,4-dimethoxyphenylethylamine like substance in Parkinson's disease, Rev. Can. Biol., 22 (1963) 469-472.
3. Barbeau, A., Tétreault, L., Oliva, L., Morazain, L. and Cardin, L., Pharmacology of akinesia; investigation on 3,4-dimethoxyphenylethylamine, Nature (London), 209 (1966) 719-721.
4. Browning, E.T., Groppi, V.E. and Kon, C., Papaverine, a potent inhibitor of respiration in C-6 astrocytoma cells, Mol. Pharmacol., 10 (1973) 175-181.
5. Collins, M.A., Neafsey, E.J., Matsubara, K., Cobuzzi, R.J. Jr. and Rollema, H., Indo-N-methylated β-carbolinium ions as potential brain-bioactivated neurotoxins, Brain Res., 570 (1992) 154-160.
6. Davila, J.C., Davis, P. and Acosta, D., Changes in glutathione and cellular energy as potential mechanisms of papaverine-induced hepatotoxicity in vitro, Toxicol. Appl. Pharmacol., 109 (1991) 28-36.
7. Davis, G.C., Williams, A.C., Markey, S.P., Ebert, M.H., Caine, E.D., Reichert, C.M. and Kopin, I.J., Chronic parkinsonism secondary to intravenous injection of meperidine analogues, Psychiatry Res., 109 (1979) 249-254.
8. Ducker, G., Raikoff, K. and Neafsey, E.J., Dopamine uptake inhibitory capacities of β-carboline and 3,4-dihydro-β-carboline analogs of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oxidation products, Brain Res., 509 (1990) 125-133.
9. Eenst, A.M., Phenomena of the hypokinetic rigid type caused by O-methylation of dopamine in he para-position, Nature (London), 193 (1962) 178-179.
10. Forno, L.S., Langston, J.W., DeLanney, L.E., Irwin, I. and Ricaurte, G.A., Locus ceruleus lesions and eosinophilic inclusions in MPTP-treated monkeys, Ann. Neurol., 20 (1986) 449-455.
11. Friedhoff, A.J. and Furiya, K., 3,4-Dimethoxyphenylacetic acid in urine, Nature (London), 214 (1967) 1127-1128.
12. Friedhoff, A.J. and Van Winkle, E., Isolation and characterization of a compound from the urine of schizophrenics, Nature (London), 194 (1962) 897-898.
13. Goto, K., Mochizuki, H., Akiyama, H. and Mizuno, Y., An immuno-histochemical study of ferritin in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys, Brain Res., 724 (1996) 125-128.
14. Hattori, N., Tanaka, M., Ozawa, T. and Mizuno, Y., Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease, Ann. Neurol., 30 (1991) 563-571.
15. Imai, H., Nakamura, T., Endo, K. and Narabayashi, H., Hemiparkinsonism in monkeys after unilateral caudate neurons infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): behavior and histology, Brain Res., 474 (1988) 327-332.
16. Javitch, J.A., D'Amato, R.J., Strittmatter, S.M. and Snyder, S.H., Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity, Proc. Natl. Acad. Sci. USA, 82 (1985) 2173-2177.
17. Kojima, T., Naoi, M. and Wakabayashi, K., 3-Amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and other heterocyclic amines as inhibitors of mitochondrial monoamine oxidases separated from human brain synaptosomes, Neurochem. Int., 16 (1990) 51-57.
18. Kowal, J. and Hirano, Y., Adrenal cells in tissue culture. The effect of papaverine and amytal on steroidogenesis, respiration and replication, Arch. Biochem. Biophys., 163 (1974) 466-475.
19. Kuehl, F.A., Ormond, R.E. and Vandenheuvel, W.J.A., Occurrence of 3,4-dimethoxyphenylacetic acid in urines of normal and schizophrenic individuals, Nature (London), 211 (1966) 606-608.
20. Langston, J.W., Ballard, P., Tetrud, J.W. and Irwin, I., Chronic parkinsonism in humans due to a product of meperidine-analog synthesis, Science, 219 (1983) 979-980.
21. Makino, Y., Ohta, S., Tachikawa, O. and Hirobe, M., Presence of tetrahydroisoquinoline and 1-methyl-tetrahydroisoquinoline in foods; compounds related to Parkinson's disease, Life Sci., 43 (1988) 373-378.
22. Mastubara, K., Collins, M.A. Akane, A., Ikebuchi, J., Neafsay, E.J., Kagawa, M. and Shiono, H., Potential bioactivated neurotoxicants, N-methylated β-carbolinium ions, are present in human brain, Brain Res., 610 (1993) 90-96.
23. Michel, P.P., Dandapani, B.K., Sanchez, R.J., Efange, S., Pressman, B.C. and Hefti, F., Toxic effects of potential environmental neurotoxins related to 1-methyl-4-phenylpyridinium on cultured rat dopaminergic neurons, J. Pharmacol. Exp. Ther., 248 (1989) 842-850.
24. Mizuno, Y., Matuda, S., Yoshino, H., Mori, H., Hattori, N. and Ikebe, S., An immunohistochemical study on α-ketoglutarate dehydrogenase complex in Parkinson's disease, Ann. Neurol., 35 (1994) 204-210.
25. Mizuno, Y., Ohta, S., Tanaka, M., Takamiya, S., Suzuki, K., Sato, T., Oya, H., Ozawa, T. and Kagawa, Y., Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease, Biochem. Biophys. Res. Commun., 163 (1989) 1450-1455.
26. Mizuno, Y., Saitoh, T. and Sone, N., Inhibition of mitochondrial alpha-ketoglutarate dehydrogenase by 1-methyl-4-phenylpyridinium ion, Biochem. Biophys. Res. Commun., 143 (1987) 971-976.
27. +, inhibit mitochondrial NADH-ubiquinone oxidoreductase activity, Proc. Jpn. Acad. Ser. b, 62 (1986) 261-263.
28. Morikawa, N. and Mizuno, Y., Effect of dopamine, dimethoxyphenylethylamine, papaverine, and related compounds on mitochondrial respiration and complex I activity: an implication to the etiology of Parkinson's disease, J. Neurochem., 66 (1996) 1174-1181.
29. +) is toxic to mesencephalic dopamine neurons in culture, Neurosci. Lett., 57 (1985) 19-24.
30. Mytilineou, C. and Friedman, L., Studies on the metabolism and toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in cultures of embryonic rat mesencephalon, J. Neurochem., 51 1988) 750-755.
31. Nagatsu, T. and Yoshida, M., An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterine in the nigrostriatal regions, Neurosci. Lett., 87 (1988) 178-182.
32. Naoi, M., Matsuura, S., Parvez, H., Takahashi, T., Hirata, Y., Minami, M. and Nagatsu, T., Oxidation of N-methyl-1,2,3,4-tetrahydroisoquinoline into the N-methyl-isoquinolinium ion by monoamine oxidase, J. Neurochem., 52 (1989) 653-655.
33. Nicklas, W.J., Vyas, I. and Heikkila, R.E., Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, Life Sci., 36 (1985) 2503-2508.
34. +) destroys cultured mesencephalic dopamine neurons, Biogenic Amines, 8 (1991) 61-67.
35. +) and tetrahydroisoquinoline derivatives on dopaminergic neurons in ventral mesencephalic-striatal co-culture, Neurodegeneration, 3 (1994) 33-42.
36. Niwa, T., Takeda, N., Kaneda, N., Hashizume, Y. and Nagatsu, T., Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in parkinsonian and normal human brains, Biochem. Biophys. Res. Commun., 144 (1987) 1084-1089.
37. Niwa, T., Takeda, N., Tatematsu, A., Matsuura, S., Yoshida, M. and Nagatsu, T., Migration of tetrahydroisoquinoline, a possible parkinsonian neurotoxin, into monkey brain from blood as proved by gas chromatography-mass spectrometry, J. Chromatogr., 452 (1988) 85-91.
38. Ohta, S., Kohno, M., Makino, Y., Tatikawa, O. and Hirobe, M., Tetrahydroisoquinoline and 1-methyl-tetrahydroisoquinoline are present in the human brain: relation to Parkinson's disease, Bimond. Res., 8 (1987) 453-456.
39. Pifl, C., Giros, B. and Caron, M.G., Dopamine transporter expression confers cytotoxicity to low-doses of parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridium, J. Neurochem., 13 (1993) 4246-4253.
40. Ramsay, R.R. and Singer, T.P., Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria, J. Biol. Chem., 261 (1986) 7585-7587.
41. Ronnov-Jessen, V. and Tjernlund, A., Hepatotoxicity due to treatment with papaverine; report of four cases, N. Engl. J. Med., 281 (1969) 1333-1335.
42. Santiago, M., Machado, A. and Cano, J., Nigral and striatal comparative study of neurotoxic action of 1-methyl-4-phenylprydium ion: involvement of dopamine uptake system, J. Neurochem., 66 (1996) 1182-1190.
43. Schapira, A.H., Cooper, J.M., Dexter, D., Jenner, P., Clark, J.B. and Marsden, C.D., Mitochondrial complex I deficiency in Parkinson's disease, Lancet, i (1989) 1269.
44. Suzuki, K., Mizuno, Y., Yamauchi, Y., Nagatsu, T. and Yoshida, M., Selective inhibition of complex I by N-methylisoquinolinium ion and N-methyl-1,2,3,4-tetrahydroisoquinoline in isolated mitochondria prepared from mouse brain, J. Neurol. Sci., 109 (1992) 219-223.
45. Suzuki, K., Mizuno, Y. and Yoshida, M., Inhibition of mitochondrial respiration by 1,2,3,4-tetrahydroisoquinoline-like endogenous alkaloids in mouse brain, Neurochem. Res., 15 (1990) 705-710.
46. Yoshida, M., Niwa, T. and Nagatsu, T., Parkinsonism in monkeys produced by chronic administration of an endogenous substance of the brain, tetrahydroisoquinoline: the behavioral and biochemical changes, Neurosci. Lett., 119 (1990) 109-113.