Effect of hypercholesterolemia on expression and function of vascular soluble guanylyl cyclase

Circulation

Volumn 105, Issue 7, 2002, Pages 855-860

  Laber, Ute ^a   Kober, Thorsten ^a   Schmitz, Verena ^a   Schrammel, Astrid ^b   Meyer, Wilfried ^c   Mayer, Bernd ^b   Weber, Martina ^a   Kojda, Georg ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF GRAZ   (Austria)

^c UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Atherosclerosis; Cardiovascular diseases; Endothelium; Nitric oxide; Signal transduction

Indexed keywords

6 ANILINO 5,8 QUINOLINEQUINONE; CD16 ANTIGEN; CHOLESTEROL; GUANYLATE CYCLASE; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; SUPEROXIDE;

ALPHA CHAIN; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROSCLEROSIS; BETA CHAIN; CHOLESTEROL DIET; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SUBUNIT; HYPERCHOLESTEROLEMIA; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; RAT; SIGNAL TRANSDUCTION; VASODILATATION; WESTERN BLOTTING;

AMINOQUINOLINES; ANIMALS; AORTA; ARTERIOSCLEROSIS; CHOLESTEROL; DIET, ATHEROGENIC; ENZYME ACTIVATION; ENZYME INHIBITORS; GUANYLATE CYCLASE; HYPERCHOLESTEROLEMIA; MALE; NITRIC OXIDE; NITRIC OXIDE DONORS; RABBITS; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION; TUNICA INTIMA; UP-REGULATION; VASODILATION; VASODILATOR AGENTS;

EID: 0037133325     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc0702.103975     Document Type: Article

References (33)

1. Mechanisms of disease: Atherosclerosis. An inflammatory disease
2. Endothelial dysfunction in atherosclerosis
3. Interactions between NO and reactive oxygen species: Pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure
4. Signal transduction using nitric oxide and cyclic guanosine monophosphate
5. Signal transduction by guanylyl cyclases
6. Modulators of soluble guanylyl cyclase
7. 1-subunit gene expression in RFL-6 rat fetal lung fibroblasts
8. Alterations of the vascular and the myocardial guanylate cyclase/cGMP-system induced by long-term hypertension in rats
9. Vasodilator dysfunction in aged spontaneously hypertensive rats: Changes in NO synthase III and soluble guanylyl cyclase expression, and in superoxide anion production
10. Downregulation of soluble guanylyl cyclase in young and aging spontaneously hypertensive rats
11. Soluble guanylate cyclase gene expression and localization in rat lung after exposure to hypoxia
12. Effects of in vivo nitroglycerin treatment on activity and expression of the guanylyl cyclase and cGMP-dependent protein kinase and their downstream target vasodilator-stimulated phosphoprotein in aorta
13. Reagent for the enzymatic determination of serum total triglycerides with improved lipolytic efficiency
14. The influence of 3-ester side chain variation on the cardiovascular profile of nitrendipine in porcine isolated trabeculae and coronary arteries
15. In vivo effects of pentaerythrityl-tetranitrate and isosorbide-5-mononitrate on the development of atherosclerosis and endothelial dysfunction in cholesterol-fed rabbits
16. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
17. Protein expression, vascular reactivity and soluble guanylate cyclase activity in mice lacking the endothelial nitric oxide synthase: Contributions of NOS isoforms to blood pressure and heart rate control
18. Guanylate cyclase
19. An unusual stable thionitrite from N-acetyl-D, L-penicillamine: X-ray crystal and molecular structure of 2-(acetylamino)-2-carboxy-1,1-dimethyl thionitrite
20. Low increase in cGMP induced by organic nitrates and nitrovasodilators improves contractile response of rat ventricular myocytes
21. Mathematical analysis of concentration-response-relationships
22. Expression of soluble guanylate cyclase activity requires both enzyme subunits
23. 1 subunit genes: Implications for coordinated transcription of two subunit genes
24. 1 subunits of the mammalian soluble guanylyl cyclase genes
25. Nitric oxide decreases stability of mRNAs encoding soluble guanylate cyclase subunits in rat pulmonary artery smooth muscle cells
26. The effect of peroxynitrite on the catalytic activity of soluble guanylyl cyclase
27. LY 83583 (6-anilino-5,8-quinolinedione) blocks nitrovasodilator induced cyclic GMP increases and inhibition of platelet activation
28. "NONOates" (I-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms
29. Mechanism of YC-1-induced activation of soluble guanylyl cyclase
30. Patent description activators of the nitric oxide sensor, soluble guanylate cyclase
31. NO-independent regulatory site on soluble guanylate cyclase
32. Activation of soluble guanylate cyclase by nitrovasodilators is inhibited by oxidized low-density lipoprotein
33. 1 gene transfer increases NO responsiveness and reduces neointima formation after balloon injury in rats via antiproliferative and antimigratory effects