pH-dependent receptor/ligand dissociation as a determining factor for intracellular sorting of ligands for epidermal growth factor receptors in rat hepatocytes

Journal of Controlled Release

Volumn 82, Issue 1, 2002, Pages 71-82

  Maeda, Kazuya ^a   Kato, Yukio ^a   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Epidermal growth factor; Hepatocytes; Intracellular sorting; Receptor mediated endocytosis; Transforming growth factor

Indexed keywords

DIGITONIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; HISTIDINE; IODINE 125; LIGAND; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL SELECTION; CELL SURFACE; CONTROLLED STUDY; DISSOCIATION; ENDOCYTOSIS; ENDOSOME; INCUBATION TIME; LIVER CELL; LIVER SINUSOID; MEMBRANE VESICLE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; TEMPERATURE;

ANIMALS; BINDING, COMPETITIVE; ENDOCYTOSIS; EPIDERMAL GROWTH FACTOR; HEPATOCYTES; HUMANS; HYDROGEN-ION CONCENTRATION; LIGANDS; MICE; MUTATION; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT PROTEINS; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 0037130172     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(02)00126-8     Document Type: Article

References (30)

1. Kinetic analysis of the elimination process of human epidermal growth factor (hEGF) in rats
2. Efficient extraction by the liver governs overall elimination of hepatocyte growth factor in rats
3. Importance of the liver in plasma clearance of hepatocyte growth factors in rats
4. Mechanism for the nonlinear pharmacokinetics of erythropoietin in rats
5. Nonlinear pharmacokinetics of a recombinant human granulocyte colony-stimulating factor derivative (nartograstim): Species differences among rats, monkeys and humans
6. Targeted delivery of peptides, proteins, and genes by receptor-mediated endocytosis
7. Polypeptide growth factors: Targeted delivery systems
8. Epidermal growth factor and transforming growth factor-alpha: Differential intracellular routing and processing of ligand-receptor complexes
9. Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction
10. Divergent effects of epidermal growth factor and transforming growth factors on a human endometrial carcinoma cell line
11. Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro
12. Superagonistic behaviour of epidermal growth factor/transforming growth factor-alpha chimaeras: Correlation with receptor routing after ligand-induced internalization
13. Dynamic determination of kinetic parameters for the interaction between polypeptide hormones and cell-surface receptors in the perfused rat liver by the multiple-indicator dilution method
14. Control of DNA synthesis and ornithine decarboxylase activity by hormones and amino acids in primary cultures of adult rat hepatocytes
15. A pharmacokinetic analysis program (multi) for microcomputer
16. Comparison of the methods for determining cell-surface and intracellular receptors for epidermal growth factor in the rat liver
17. A single amino acid exchange, Arg-45 to Ala, generates an epidermal growth factor (EGF) mutant with high affinity for the chicken EGF receptor
18. Characterization of degP, a gene required for proteolysis in the cell envelope and essential for growth of Escherichia coli at high temperature
19. Comparison of specific binding of human epidermal growth factor (EGF) to sinusoidal and bile canalicular membranes isolated from rat liver
20. The large intracellular pool of asialoglycoprotein receptors functions during the endocytosis of asialoglycoproteins by isolated rat hepatocytes
21. Modification of a receptor-binding surface of epidermal growth factor (EGF): Analogs with enhanced receptor affinity at low pH or at neutrality
22. Quantitation of intracellular membrane-bound enzymes and receptors in digitonin-permeabilized cells
23. Regulation of insulin, epidermal growth factor, and transforming growth factor-alpha levels by growth factor-degrading enzymes
24. Intraendosomal degradation of transforming growth factor alpha
25. Selective degradation of insulin within rat liver endosomes
26. Identification of the cleavage sites of transforming growth factor alpha by insulin-degrading enzymes
27. Sequential processing of epidermal growth factor in early and late endosomes of rat liver
28. Structure-function relationships for the EGF/TGF-alpha family of mitogens
29. The solution structures of epidermal growth factor and transforming growth factor alpha
30. Kinetic analysis of the downregulation of epidermal growth factor receptors in rats in vivo