Intraendosomal degradation of transforming growth factor alpha

Molecular and Cellular Endocrinology

Volumn 126, Issue 2, 1997, Pages 185-192

  Hamel, Frederick G ^a   Siford, Gerri L ^a   Jones, June ^a   Duckworth, William C ^b  

^a VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Endosomes; Epidermal growth factor (EGF); Hepatocyte; Insulin degrading enzyme; Transforming growth factor alpha (TGF)

Indexed keywords

EPIDERMAL GROWTH FACTOR; INSULINASE; PROTEINASE INHIBITOR; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOSOME; LIVER CELL; LYSOSOME; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

ANIMALS; ENDOSOMES; EPIDERMAL GROWTH FACTOR; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 0031557112     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(96)03981-0     Document Type: Article

References (29)

1. Brenner, D.A., Koch, K.S. and Leffert, H.L. (1989) Transforming growth factor-α stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. DNA, 279-285.
2. Cardelli, J.A., Richardson, J. and Meiars, D. (1989) Role of acidic intracellular compartment in the biosynthesis of dictyostelium lysosomal enzymes. J. Biol. Chem., 3454-3463.
3. Decker, S.J. (1990) Epidermal growth factor and transforming growth factor-alpha induce differential processing of the epidermal growth factor receptor. Biochem. Biophys. Res. Commun., 615-621.
4. Dunn, W., and Hubbard, A. (1984) Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: Ligand and receptor dynamics. J. Cell Biol., 2148-2159.
5. Dunn, W.A., Connolly, T.P. and Hubbard, A.L. (1986) Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: Receptor pathway. J. Cell Biol., 24-36.
6. Ebner, R. and Derynck, R. (1991) Epidermal growth factor and transforming growth factor-α: Differential intracellular routing and processing of ligand-receptor complexes. Cell Regulation, 599-612.
7. Gan, B.S., Hollenberg, M.D., MacCannell, K.L., Lederis, K., Winkler, M.E. and Derynck, R. (1987) Distinct vascular actions of epidermal growth factor-urogastrone and transforming growth factor-α. J. Pharmacol. Exp. Ther., 331-337.
8. Gehm, B.D. and Rosner, M.R. (1991) Regulation of insulin, epidermal growth factor, and transforming growth factor-α levels by growth factor degrading enzymes. Endocrinology, 1603-1609.
9. Hamel, F.G., Mahoney, M.J. and Duckworth, W.C. (1991) Degradation of intraendosomal insulin by insulin degrading enzyme without acidification. Diabetes, 436-443.
10. Hamel, F.G., Peavy, D.E., Ryan, M.P. and Duckworth, W.C. (1987) High performance liquid chromatographic analysis of insulin degradation products from isolated hepatocytes: Effects of inhibitors suggest intracellular and extracellular pathways. Diabetes, 702-708.
11. Hamel, F.H., Gehm, B.D., Rosner, M.R. and Duckworth, W.C. (1996) Identification of the cleavage sites of transforming growth factor-α by insulin degrading enzymes. Biochim. Biophys. Acta. (Submitted for publication).
12. Kahn, M.N., Posner, B.I., Kahn, R.J. and Bergeron, J.J.M. (1982) Internalization of insulin into rat liver Golgi element. J. Biol. Chem., 5969-5976.
13. Korc, M. and Finman, J.E. (1989) Attenuated processing of epidermal growth factor in the face of marked degradation of transforming growth factor-α. J. Biol. Chem., 14990-14999.
14. Korc, M., Haussler, C.A. and Trookman, N.S. (1987) Divergent effects of epidermal growth factor and transforming growth factors on a human endometrial carcinoma cell line. Cancer Res., 4909-4914.
15. Matrisian, L.M., Planck, S.R. and Magun, B. (1984) Intracellular processing of epidermal growth factor. J. Biol. Chem., 3047-3052.
16. Maxfield, F., Willingham, M., Davies, P. and Pastan, I. (1979) Amines inhibit the clustering of α2-macroglobulin and EGF on the fibroblast cell surface. Nature, 661-667.
17. Peavy, D.E., Edmondson, J.W. and Duckworth, W.C. (1984) Selective effects of inhibitors of hormone processing on insulin action in isolated hepatocytes. Endocrinology, 753-760.
18. Planck, S., Finch, J. and Magun, B. (1984) Intracellular procesing of peidermal growth factor. J. Biol. Chem., 3053-3057.
19. Prywes, R., Livneh, E., Ullrich, A. and Schlessinger, J. (1986) Mutations in the cytoplasmic domain of EGF-receptors affect EGF binding and receptor internalization. EMBO J., 2179-2190.
20. Renfrew, C.A. and Hubbard, A.L. (1991) Sequential processing of epidermal growth factor in early and late endosomes of rat liver. J. Biol. Chem., 4348-4356.
21. Schaudies, R. and Wray, H. (1988) Inhibition of EGF processing in responsive and nonresponsive human fibroblasts. J. Cell. Physiol., 79-86.
22. 125I-labeled epidermal growth factor by normal human foreskin fibroblasts. Endocrinology, 875-882.
23. Schneider, D.L. (1987) The proton pump ATPase of lysosomes and related organellels of the vacuolar apparatus. Biochim. Biophys. Acta, 1-10.
24. Schreiver, A., Winkler, M. and Derynck, R. (1986) Transforming growth factor-α: A more potent angiogenic mediator than epidermal growth factor. Science, 1250-1253.
25. Shii, K., Yokono, K., Baba, S. and Roth, R.A. (1986) Purification and characterization of insulin-degrading enzyme from human erythrocytes. Diabetes, 675-683.
26. 125I-insulin by rat hepatocytes. J. Biol. Chem., 8389-8398.
27. Wakshull, E. and Wharton, W. (1985) Stabilized complexes of epidermal growth factor and its receptor on the cell surface stimulate RNA synthesis but not mitogenesis. Proc. Natl. Acad. Sci., 8513-8517.
28. Wiley, H.S., Van Nostrand, W., McKinley, D. and Cunningham, D. (1985) Intracellular processing of epidermal growth factor and its effect on ligand-receptor interactions. J. Biol. Chem., 5290-5295.
29. Willingham, M.C. and Pastan, I.H. (1982) Transit of epidermal growth factor through coated pits of the Golgi system. J. Cell. Biol., 207-212.