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Journal of the American Chemical Society

Volumn 124, Issue 28, 2002, Pages 8268-8274

Formation of cyclopropanone during cytochrome P450-catalyzed N-dealkylation of a cyclopropylamine

(4) Shaffer, Christopher L a,b Harriman, Shawn a,b Koen, Yakov M a Hanzlik, Robert P a

a UNIVERSITY OF KANSAS (United States)

b PFIZER INC (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEALKYLATION;

ELECTRON TRANSITIONS; HYDROXYLATION; METABOLITES; PEROXIDES;

PROPANE;

2,4 DINITROPHENYLHYDRAZINE; 4 HYDROXY N CYCLOPROPYL N METHYLANILINE; ACROLEIN; ANILINE DERIVATIVE; CYCLOPROPANE DERIVATIVE; CYCLOPROPYLAMINE; CYTOCHROME P450; HORSERADISH PEROXIDASE; METHYLANILINE; N (1' METHYLCYCLOPROPYL) N METHYLANILINE; N CYCLOPROPYL N METHYLANILINE; N CYCLOPROPYLANILINE; PROPIONALDEHYDE; PROPIONIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; DEALKYLATION; DEMETHYLATION; ELECTRON TRANSPORT; ENZYME INACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; LIVER MICROSOME; OXIDATION;

ALKYLATION; ANILINE COMPOUNDS; CYCLOPROPANES; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 ENZYME SYSTEM;

EID: 0037125528 PISSN: 00027863 EISSN: None Source Type: Journal
DOI: 10.1021/ja0119346 Document Type: Article

Times cited : (84)

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