7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: A potential treatment for asthma

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 18, 2000, Pages 2137-2140

  Buckley, George ^a   Cooper, Nicola ^a   Dyke, Hazel J ^a   Galleway, Fiona ^a   Gowers, Lewis ^a   Gregory, Joanna C ^a   Hannah, Duncan R ^a   Haughan, Alan F ^a   Hellewell, Paul G ^b   Kendall, Hannah J ^a   Lowe, Christopher ^a   Maxey, Robert ^a   Montana, John G ^a   Naylor, Robert ^c   Picken, C Louise ^a   Runcie, Karen A ^a   Sabin, Verity ^a   Tuladhar, Bishwa R ^b   Warneck, Julie B H ^a  

^a UCB PHARMA   (Belgium)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; BENZOFURAN DERIVATIVE; PHOSPHODIESTERASE IV INHIBITOR; PICLAMILAST; ROLIPRAM;

ANIMAL MODEL; ARTICLE; ASTHMA; DRUG BINDING; DRUG POTENCY; DRUG SYNTHESIS; EOSINOPHILIA; FERRET; GUINEA PIG; NONHUMAN;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ADMINISTRATION, ORAL; ANIMALS; ASTHMA; BENZAMIDES; BENZOFURANS; EOSINOPHILIA; GUINEA PIGS; INHIBITORY CONCENTRATION 50; PHOSPHODIESTERASE INHIBITORS; PYRIDINES; ROLIPRAM; STRUCTURE-ACTIVITY RELATIONSHIP; VOMITING;

ANIMALIA; CAVIA PORCELLUS; MUSTELA PUTORIUS FURO; SUS SCROFA;

EID: 0033822502     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00426-1     Document Type: Article

References (21)

1. Pulmon
2. The use of benzofuran rings to replace the 3,4-dialkoxy subunit of rolipram has also been reported Rhone-Poulenc Rorer