Role of antioxidants in the O-hydroxyethyl-D-(Ser)8-cyclosporine A (SDZ IMM125)-induced apoptosis in rat hepatocytes

Biochemical Pharmacology

Volumn 64, Issue 12, 2002, Pages 1725-1736

  Grub, Sibylle ^a   Trommer, Wolfgang E ^b   Wolf, Armin ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

Author keywords

Antioxidants; Apoptosis; Ca2+; Cyclosporine A; Prooxidants; SDZ IMM125

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; BUTHIONINE SULFOXIMINE; CALCIUM; CALCIUM ANTAGONIST; CALCIUM CHELATING AGENT; CASPASE 3; CYCLOSPORIN A [8 DEXTRO O (2 HYDROXYETHYL)SERINE]; DITHIOTHREITOL; ENZYME INHIBITOR; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GLUTATHIONE SYNTHASE; REDUCING AGENT; TOCOFERSOLAN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CHROMATIN CONDENSATION; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVATION; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIMETABOLITES; ANTIOXIDANTS; APOPTOSIS; BUTHIONINE SULFOXIMINE; CALCIUM; CASPASE 3; CASPASES; CHROMATIN; CYCLOSPORINE; CYCLOSPORINS; DNA FRAGMENTATION; DRUG INTERACTIONS; HEPATOCYTES; L-LACTATE DEHYDROGENASE; MALE; RATS; RATS, WISTAR;

EID: 0037114490     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01384-9     Document Type: Article

References (49)

1. Borel J.F., Baumann G., Chapman I., Donatsch P., Fahr A., Mueller E.A., Vigouret J.-M. In vivo pharmacological effects of ciclosporin and some analogues. Adv. Pharmacol. 35:1996;115-246.
2. Kahan B.D. Cyclosporine: the base for immunosuppressive therapy - present and future. Transplant Proc. 25:1993;508-510.
3. Rush D.N. Cyclosporine toxicity to organs other than the kidney. Clin. Biochem. 24:1991;101-105.
4. Wolf A., Donatsch P. Cyclosporin A-dependent induction of lipid peroxidation in rat liver and kidney. Free Radic. Biol. Med. 9:1990;123.
5. Donatsch P., Mason J., Richardson B.P., Ryffel B. Toxicological evaluation of the new cyclosporin derivative, SDZ IMM-125, in a comparative, subchronic toxicity study in rats. Transplant Proc. 24(4 Suppl. 2):1992;39-42.
6. Hiestand P.C., Gräber M., Hurtenbach U., Herrman P., Cammisuli S., Richardson B.P., Eberle M.K., Borel J.F. The new cyclosporine derivative, SDZ IMM125: in vitro and in vivo pharmacologic effects. Transplant Proc. 24:1992;31-38.
7. Witkamp L., Zonneveld I.M., Jung E.G., Schopf R.E., Christophers E., Grossmann R., Meffert H., Belaich S., Mahrle G., Van Joost T., Stoof T., Bos J.D., Mayer H., Taesch S., Feutren G. Efficacy and tolerability of multi-dose SDZ IMM125 in patients with severe psoriasis. Br. J. Dermatol. 133:1995;95-103.
8. Wolf A., Schramm U., Fahr A., Aicher L., Cordier A., Trommer W.E., Fricker G. Hepatocellular effects of cyclosporine A and its derivative SDZ IMM125 in vitro. J. Pharmacol. Exp. Ther. 284:1998;817-825.
9. 8-cyclosporine A derivative SDZ IMM125 in rat hepatocytes. J. Pharmacol. Exp. Ther. 29:2000;24-32.
10. Wolf A., Trendelenburg C.-F., Diez-Fernandez C., Prieto P., Houy S., Trommer W.E., Cordier A. Cyclosporine A-induced oxidative stress in rat hepatocytes. J. Pharmacol. Exp. Ther. 280:1997;1328-1334.
11. Trendelenburg, C-F. Oxidativer Stress als Mechanismus der Cyclosporin A-Toxizität in Rattenhepatozyten Primärkulturen. Dissertation D386, Fachbereich Chemie, Universität Kaiserslautern; 1995.
12. Buttke T.M., Sandstrom P.A. Oxidative stress as a mediator of apoptosis. Immunol. Today. 15:1994;7-10.
13. Kehrer J.P. Free radicals as mediators of tissue injury and disease. Crit. Rev. Toxicol. 23:1993;21-48.
14. Jabs T. Reactive oxygen intermediates as mediators of programmed cell death in plants and animals. Biochem. Pharmacol. 57:1999;231-245.
15. Higuchi M., Honda T., Proske R.J., Yeh E.T. Regulation of reactive oxygen species-induced apoptosis and necrosis by caspase 3-like proteases. Oncogene. 17:1998;2753-2760.
16. Hampton M.B., Fadeel B., Orrenius S. Redox regulation of the caspases during apoptosis. Ann. N.Y. Acad. Sci. 854:1998;328-335.
17. 2+ in toxic cell killing. Trends Pharmacol. Sci. 10:1989;281-285.
18. Orrenius S. Mechanisms of oxidative cell damage. In: Poli G, Albano E, Dianzani MU, editors. Free radicals: From Basic Science to Medicine. Basel: Birkhäuser Verlag; 1993, p. 47-64.
19. 2+ fluxes in isolated hepatocytes. J. Biol. Chem. 260:1985;13613-13618.
20. 2+ homeostasis, cell death, proliferation and differentiation. Chem. Biol. Interact. 77:1991;1-23.
21. Kruman I.I., Mattson M.P. Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis. J. Neurochem. 72:1999;529-540.
22. Guerrero A, Arias JM. Apoptosis. In: Sperelakis N, editor. Cell Physiology Source Book Section IX Cell Division and programmed cell death. San Diego: Academic Press; 1998.
23. McConkey D.J., Hartzell P., Nicotera P., Orrenius S. Calcium-activated DNA fragmentation kills immature thymocytes. FASEB J. 3:1989;1843-1849.
24. Boelsterli U.A., Wolf A., Göldlin C. Oxygen free radical production mediated by cocaine and its ethanol-derived metabolite, cocaethylene, in rat hepatocytes. Hepatology. 18:1993;1154-1161.
25. Welder AA, Acosta D. Membrane integrity and function. In: Tyson CA, Frazier JM, editors. Methods in Toxicology. San Diego: Academic Press; 1994, p. 46-9.
26. Lillie RD, Fullmer HM. Histopathological techniques and practical histochemistry. New York: McGraw-Hill; 1976.
27. Rodriguez I., Matsura K., Ody C., Nagata S., Vassalli P. Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death. J. Exp. Med. 184:1996;2067-2072.
28. 2+ influx in rat aortic smooth muscle cells Biochem. Biophys. Res. Commun. 148:1987;273-278.
29. Bradford M.A. Rapid and sensitive method for the quantification of microgram amounts of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
30. Hayter A.J. Pairwise comparisons of generally correlated means. J. Am. Stat. Assoc. 84:1989;208-213.
31. Sidak Z. Rectangular confidence regions for the means of multivariate normal distributions. J. Am. Stat. Assoc. 62:1967;626-633.
32. Dunnett C.W. New tables for multiple comparisons with a control. Biometrics. 20:1964;482-491.
33. Grub S., Persohn E., Trommer W.E., Wolf A. Mechanisms of cyclosporine A-induced apoptosis in rat hepatocyte primary cultures. Toxicol. Appl. Pharmacol. 163:2000;209-220.
34. Roman I.D., Rodríguez-Henche N., Furyo J.A., Zueco J.A., Menor C., Prieto J.C., Guijarro L.G. Cyclosporin A induces apoptosis in rat hepatocytes in culture. Arch. Toxicol. 72:1998;559-565.
35. Lemaire C., Andreau K., Souvannavong V., Adam A. Inhibition of caspase activity induces a switch from apoptosis to necrosis. FEBS Lett. 425(2):1998;266-270.
36. Leist M., Single B., Castoldi A.F., Kuhnle S., Nicotera P. Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J. Exp. Med. 185(8):1997;1481-1486.
37. Ellouk-Achard S., Martin C., Pham-Huy C., Duc T.H., Thevenin M., Dutertre-Catella P., Warnet J.M., Claude J.R. Implication of Cyp 3A in the toxicity of cyclosporin G (CsG), cyclosporin A (CsA) and FK506 on rat hepatocytes in primary culture. Arch. Toxicol. 71:1997;437-442.
38. Meyer-Lehnert H., Schrier R.W. Potential mechanism of cyclosporine A-induced vascular smooth muscle contraction. Hypertension. 13:1989;352-360.
39. Lo Russo A., Passaquin A.C., André P., Skutella M., Rüegg U.T. Effect of cyclosporin A and analogues on cytosolic calcium and vasoconstriction: possible lack of relationship to immunosuppressive activity. Br. J. Pharmacol. 118:1996;885-892.
40. Nicotera P., Zhivotovsky B., Orrenius S. Nuclear calcium transport and the role of calcium in apoptosis. Cell Calcium. 16:1994;279-288.
41. 2+ ATPase in microsomes of pulmonary smooth muscle. Indian J. Biochem. Biophys. 33:1996;414-419.
42. Nanji A.A., Sadrzadeh S.M. Effect of fish oil and Vitamin E on ethanol-induced changes in membrane ATPases. Life Sci. 55:1994;PL245-PL249.
43. Kass G.E.N., Wright J.M., Nicotera P., Orrenius S. The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: role of intracellular calcium. Arch. Biochem. Biophys. 260:1988;789-797.
44. Albano E., Bellomo G., Parola M., Carini R., Dianzani M.U. Stimulation of lipid peroxidation increases the intracellular calcium content of isolated hepatocytes. Biochim. Biophys. Acta. 1091:1991;310-316.
45. 2+-ATPase activity in rat liver plasma membranes following carbon tetrachloride intoxication. Chem. Biol. Interact. 73:1990;103-119.
46. Britigan B.E., Rasmussen G.T., Cox C.D. Binding of iron and inhibition of iron-dependent oxidative cell injury by the calcium chelator 1,2-bis(2-aminophenoxy)ethane N,N,N′,N′-tetraacetic acid (BAPTA). Biochem. Pharmacol. 55:1998;287-295.
47. Tsien R.Y. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 19:1980;2396-2404.
48. 2+ channel blockers verapamil and nifedipine inhibit apoptosis induced by 25-hydroxycholesterol in human aortic smooth muscle cells. J. Lipid Res. 38:1997;2049-2061.
49. Waters D. Calcium channel blockers: an evidence-based review. Can. J. Cardiol. 13:1997;757-766.