High affinity mimotope of the polysaccharide capsule of Cryptococcus neoformans identified from an evolutionary phage peptide library

Journal of Immunology

Volumn 169, Issue 12, 2002, Pages 6992-6999

  Beenhouwer, David O ^a,b   May, Rena J ^a   Valadon, Philippe ^a,c   Scharff, Matthew D ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SIDNEY KIMMEL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLUCURONOXYLOMANNAN; MANNAN; MONOCLONAL ANTIBODY; POLYSACCHARIDE; SYNTHETIC PEPTIDE; TETANUS TOXOID; UNCLASSIFIED DRUG; BACTERIOPHAGE FD GENE 3 PROTEIN; CRYPTOCOCCAL POLYSACCHARIDE; DNA BINDING PROTEIN; FUNGUS ANTIBODY; FUNGUS ANTIGEN; FUNGUS VACCINE; PEPTIDE; PEPTIDE LIBRARY; VIRUS FUSION PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM INFECTION; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; FUNGAL MENINGITIS; IMMUNE RESPONSE; MENINGITIS; MOUSE; NONHUMAN; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANIMAL; ANTIBODY COMBINING SITE; BACTERIOPHAGE M13; BAGG ALBINO MOUSE; BIOSYNTHESIS; IMMUNOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; MENINGOENCEPHALITIS; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; MOLECULAR MIMICRY; NUCLEOTIDE SEQUENCE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, FUNGAL; ANTIBODIES, MONOCLONAL; ANTIGENS, FUNGAL; BACTERIOPHAGE M13; BASE SEQUENCE; BINDING SITES, ANTIBODY; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; DNA-BINDING PROTEINS; EVOLUTION, MOLECULAR; FUNGAL VACCINES; INJECTIONS, INTRAPERITONEAL; MENINGOENCEPHALITIS; MICE; MICE, INBRED BALB C; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PEPTIDES; POLYSACCHARIDES; TETANUS TOXOID; VIRAL FUSION PROTEINS;

EID: 0037114161     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.12.6992     Document Type: Article

References (50)

1. Tunkel, A. R., and W. M. Scheld. 1995. Acute meningitis. In Principles and Practice of Infectious Diseases, Vol, 1. G. L. Mandell, J. E. Bennett, and R, Dolin, eds. Churchill Livingstone, New York, p. 831.
2. Austrian, R. 1985. Polysaccharide vaccines. Ann. Inst. Pasteur. Microbiol. 136B:295.
3. Mond, J. J., A. Lees, and C. M, Snapper. 1995. T cell-independent antigens type 2. Annu. Rev. Immunol. 13:655.
4. Pirofski, L. A. 2001. Polysaccharides, mimotopes and vaccines for fungal and encapsulated pathogens. Trends Microbiol. 9:445.
5. Centers for Disease Control. 1999. Impact of vaccines universally recommended for children: United States, 1990-1998. Morb. Mortal. Wkly. Rep. 48:243.
6. Robbins, J. B., R. Schneerson, P. Anderson, and D. H. Smith. 1996. The 1996 Albert Lasker Medical Research Awards: prevention of systemic infections, especially meningitis, caused by Haemophilus influenzae type b; impact on public health and implications for other polysaccharide-based vaccines. JAMA 276:1181.
7. Ahman, H., H. Kayhty, H. Lehtonen, O. Leroy, J, Froeschle, and J. Eskola. 1998. Streptococcus pneumoniae capsular polysaccharide-diphtheria toxoid conjugate vaccine is immunogenic in early infancy and able to induce immunologic memory. Pediatr. Infect. Dis. J. 17:211.
8. Sorensen, R. U., L. E. Leiva, P. A. Giangrosso, B. Butler, F. C. Javier III, D. M. Sacerdote, N. Bradford, and C. Moore. 1998. Response to a heptavalent conjugate Streptococcus pneumoniae vaccine in children with recurrent infections who are unresponsive to the polysacchajide vaccine. Pediatr. Infect. Dis. J. 17:685.
9. Butterworth, A. E., R. Bensted-Smith, A. Capron, M. Capron, P. R. Dalton, D. W. Dunne, J. M. Grzych, H. C. Kariuki, J. Khalife, D, Koech, et al. 1987. Immunity in human Schistosomiasis mansoni: prevention by blocking antibodies of the expression of immunity in young children. Parasitology 94:281.
10. Grzych, J. M., M. Capron, C. Dissous, and A. Capron. 1984. Blocking activity of rat monoclonal antibodies in experimental schistosomiasis. J. Immunol. 133:998.
11. Joiner, K. A., R. Scales, K. A. Warren, M. M. Frank, and P. A. Rice. 1985. Mechanism of action of blocking immunoglobulin G for Neisseria gonorrhoeae. J. Clin. Invest. 76:1765.
12. Nussbaum, G., W. Cleare, A. Casadevall, M. D. Scharff, and P. Valadon. 1997. Epitope location in the Cryptococcus neoformans capsule is a determinant of antibody efficacy. J. Exp. Med. 185:685.
13. Rice, P. A., and D. L. Kasper. 1982. Charactenzation of serum resistance of Neisseria gonorrhoeae that disseminate: roles of blocking antibody and gonococcal outer membrane proteins. J. Clin, Invest. 70:157.
14. Yi, X. Y., A. J. Simpson, R. de Rossi, and S. R. Smithers. 1986. The presence of antibody in mice chronically infected with Schistosoma mansoni which blocks in vitro killing of schistosomula. J. Immunol. 137:3955.
15. Pirofski, L. A., and A. Casadevall. 1998. Use of licensed vaccines for active immunization of the immunocompromised host. Clin. Microbiol. Rev. 11:1.
16. Clumeck, N., J. Sonnet, H. Taelman, F. Mascart-Lemone, M. De Bruyere, P. Vandeperre, J. Dasnoy, L. Marcelis, M. Lamy, C. Jonas, et al. 1984. Acquired immunodeficiency syndrome in African patients. N. Engl. J. Med. 310:492.
17. Currie, B. P., and A. Casadevall, 1994. Estimation of the prevalence of cryptococcal infection among patients infected with the human immunodeficiency virus in New York City. Clin. Infect. Dis. 19:1029.
18. Zuger, A., E. Louie, R. S. Holzman, M. S. Simberkoff, and J. J. Rahal, 1986. Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Diagnostic features and outcome of treatment. Ann. Intern. Med. 104:234.
19. Casadevall, A., and J. R. Perfect. 1998. Cryptococcus neoformans. ASM Press. Washington, D.C.
20. van der Horst, C. M., M. S. Saag, G. A. Cloud, R. J. Hamill, J. R. Graybill, J. D. Sobel, P. C. Johnson, C. U. Tuazon, T. Kerkering, B. L. Moskovitz, et al. 1997. Treatment of cryptococcal meningitis associated with the acquired immunodeficiency syndrome. N. Engl. J. Med. 337:15.
21. Casadevall, A. 1995. Antibody immunity and invasive fungal infections. Infect. Immun. 63:4211.
22. Mukherjee, J., G. Nussbaum, M. D. Scharff, and A. Casadevall. 1995. Protective and nonprotective monoclonal antibodies to Cryptococcus neoformans originating from one B cell. J. Exp. Med. 181:405.
23. Nussbaum, G., R. Yuan, A. Casadevall, and M. D. Scharff. 1996. Immunoglobulin G3 blocking antibodies to the fungal pathogen Cryptococcus neoformans. J. Exp. Med. 183:1905.
24. MacGill, T. C., R. S. MacGill, A. Casadevall, and T. R. Kozel. 2000. Biological correlates of capsular (quellung) reactions of Cryptococcus neoformans. J. Immunol. 164:4835.
25. Nussbaum, G., R. R. Yuan, A. Casadevall, P. Valadon, and M. D. Scharff. 1995. Vaccination elicits protective and nonprotective antibodies to Cryptococcus neoformans. Vaccines 95:231.
26. Valadon, P., G. Nussbaum, L. F. Boyd, D. H. Margulies, and M. D. Scharff. 1996. Peptide libraries define the fine specificity of anti-polysaccharide antibodies to Cryptococcus neoformans. J. Mol. Biol. 261:11.
27. Valadon, P., G. Nussbaum, J. Oh, and M. D. Scharff. 1998. Aspects of antigen mimicry revealed by immunization with a peptide mimetic of Cryptococcus neoformans polysaccharide. J. Immunol. 161:1829.
28. Mukherjee, J., A. Casadevall, and M. D. Scharff. 1993. Molecular characterization of the humoral responses to Cryptococcus neoformans infection and glucuronoxylomannan-tetanus toxoid conjugate immunization. J. Exp. Med. 177:1105.
29. Young, A. C., P. Valadon, A. Casadevall, M. D. Scharff, and J. C. Sacchettini. 1997. The three-dimensional structures of a polysaccharide binding antibody to Cryptococcus neoformans and its complex with a peptide from a phage display library: implications for the identification of peptide mimotopes. J. Mol. Biol. 274:622.
30. Cwirla, S. E., E. A. Peters, R. W. Barrett, and W. J. Dower. 1990. Peptides on phage: a vast library of peptides for identifying ligands. Proc. Natl. Acad. Sci. USA 87:6378.
31. Parmley, S. F., and G. P. Smith. 1988. Antibody-selectable filamentous fd phage vectors: affinity purification of target genes. Gene 73:305.
32. Scott, J. K., and G. P. Smith. 1990. Searching for peptide ligands with an epitope library. Science 249:386.
33. Kozel, T. R. 1983. Dissociation of a hydrophobic surface from phagocytosis of encapsulated and non-encapsulated Cryptococcus neoformans. Infect. Immun. 39:1214.
34. Mukherjee, J., M. D. Scharff, and A. Casadevall. 1992. Protective murine monoclonal antibodies to Cryptococcus neoformans. Infect. Immun. 60:4534.
35. Mukherjee, J., L. A. Pirofski, M. D. Scharff, and A. Casadevall. 1993. Antibody-mediated protection in mice with lethal intracerebral Cryptococcus neoformans infection. Proc. Natl. Acad. Sci. USA 90:3636.
36. Mukherjee, S., S. Lee, J. Mukherjee, M. D. Scharff, and A. Casadevall. 1994. Monoclonal antibodies to Cryptococcus neoformans capsular polysaccharide modify the course of intravenous infection in mice. Infect. Immun. 62:1079.
37. Nakouzi, A., P. Valadon, J. Nosanchuk, N. Green, and A. Casadevall. 2001. Molecular basis for immunoglobulin M specificity to epitopes in Cryptococcus neoformans polysaccharide that elicit protective and nonprotective antibodies. Infect. Immun. 69:3398.
38. Cleare, W., R. Cherniak, and A. Casadevall. 1999. In vitro and in vivo stability of a Cryptococcus neoformans glucuronoxylomannan epitope that elicits protective antibodies. Infect. Immun. 67:3096.
39. Nussbaum, G. J., S. Anandasabapathy, J. Mukherjee, M. Fan, A. Casadevall, and M. D. Scharff. 1999, Molecular and idiotypic analysis of the antibody response to Cryptococcus neoformans glucuronoxylomannan-protein conjugate vaccine in autoimmune and non-autoimmune mice. Infect. Immun. 67:4469.
40. Casadevall, A., M. DeShaw, M. Fan, F. Dromer, T. R. Kozel, and L. A. Pirofski, 1994. Molecular and idiotypic analysis of antibodies to Cryptococcus neoformans glucuronoxylomannan. Infect. Immun. 62:3864.
41. Bona, C. 1993. Molecular characteristics of anti-polysaccharide antibodies. Springer Semin. Immunopathol. 15:103.
42. Kieber-Emmons, T. 1998. Peptide mimotopes of carbohydrate antigens. Immunol. Res. 17:95.
43. Monzavi-Karbassi, B., G. Cunto-Amesty, P. Luo, and T. Kieber-Emmons. 2002. Peptide mimotopes as surrogate antigens of carbohydrates in vaccine discovery. Trends Biotechnol. 20:207.
44. Irving, M. B., O. Pan, and J. K. Scott. 2001. Random-peptide libraries and antigen-fragment libraries for epitope mapping and the development of vaccines and diagnostics. Curr. Opin. Chem. Biol. 5:314.
45. Zwick, M. B., J. Shen, and J. K. Scott. 1998. Phage-displayed peptide libraries. Curr. Opin. Biotechnol. 9:427.
46. Harris, S. L., L. Craig, J. S. Mehroke, M. Rashed, M. B. Zwick, K. Kenar, E. J. Toone, N. Greenspan, F. I. Auzanneau, J. R. Marino-Albernas, et al. 1997. Exploring the basis of peptide-carbohydrate crossreactivity: evidence for discrimination by peptides between closely related anti-carbohydrate antibodies. Proc. Natl. Acad. Sci. USA 94:2454.
47. Fleuridor, R., A. Lees. and L. Pirofski. 2001. A cryptococcal capsular polysaccharide mimotope prolongs the survival of mice with Cryptococcus neoformans infection, J. Immunol. 166:1087.
48. Phalipon, A., A. Folgori, J. Arondel, G, Sgaramella, P. Fortugno, R. Cortese, P. J. Sansonetti, and F. Felici. 1997. Induction of anti-carbohydrate antibodies by phage library-selected peptide mimics. Eur. J. Immunol. 27:2620.
49. Zhang, H., Z. Zhong, and L. A, Pirofski. 1997. Peptide epitopes recognized by a human anti-cryptococcal glucuronoxylomannan antibody. Infect. Immun. 65:1158.
50. Smith, G. P., and V. A. Petrenko. 1997. Phage display. Chem. Rev. 97:391.