Epitope location in the Cryptococcus neoformans capsule is a determinant of antibody efficacy

Journal of Experimental Medicine

Volumn 185, Issue 4, 1997, Pages 685-694

  Nussbaum, Gabriel ^a   Cleare, Wendy ^a   Casadevall, Arturo ^a   Scharff, Matthew D ^a   Valadon, Philippe ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; FUNGUS ANTIBODY; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 12A1; MONOCLONAL ANTIBODY 13F1; POLYSACCHARIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; FEMALE; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; CRYPTOCOCCUS NEOFORMANS; EPITOPES; MICE; MICROSCOPY, IMMUNOELECTRON;

EID: 0031035947     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.4.685     Document Type: Article

References (33)

1. Majer, M. 1972. Virus sensitization. Curr. Top. Microbiol. Immunol. 58:69-84.
2. Jones, K.F., and V.A. Fischetti. 1988. The importance of the location of antibody binding on the M6 protein for opsonization and phagocytosis of group A M6 streptococci. J. Exp. Med. 167:1114-1123.
3. Casadevall, A. 1995. Antibody immunity and invasive fungal infections. Infect. Immun. 63:4211-4218.
4. Han, Y., and J.E. Cutler. 1995. Antibody response that protects against disseminated candidiasis. Inject. Immun. 63:2714-2719.
5. Mukherjee, J., G. Nussbaum, M.D. Scharff, and A. Casadevall. 1995. Protective and nonprotective monoclonal antibodies to Cryptococcus neoformans originating from one B cell. J. Exp. Med. 181:405-409.
6. Currie, B.P., and A. Casadevall. 1994. Estimation of the prevalence of cryptococcal infection among patients infected with the human immunodeficiency virus in New York City. Clin. Infect. Dis. 19:1029-1033.
7. Kozel, T.R., G.S. Pfrommer, A.S. Guerlain, B.A. Highison, and G.J. Highison. 1988. Role of the capsule in phagocytosis of Cryptococcus neoformans. Rev. Infect. Dis. 2(Suppl.):436-439.
8. Murphy, J.W., and G.C. Cozad. 1972. Immunological unresponsiveness induced by cryptococcal capsular polysaccharide assayed by the hemolytic plaque technique. Inject. Immun. 5: 896-901.
9. Dong, Z.M., and J.W. Murphy. 1995. Effects of the two varieties of Cryptococcus neoformans cells and culture filtrate antigens on neutrophil locomotion. Inject. Immun. 63:2632-2644.
10. Pettoello-Mantovani, M., A. Casadevall, T.R. Kollmann, A. Rubinstein, and H. Goldstein. 1992. Enhancement ot HIV-1 infection by the capsular polysaccharide of Cryptococcus neoformans. Lancet. 339:21-23.
11. Mukherjee, S., S.C. Lee, and A. Casadevall. 1995. Antibodies to Cryptococcus neoformans glucuronoxylomannan enhance antifungal activity of murine macrophages. Infect. Immun. 63: 573-579.
12. Dromer, F., J. Charreire, A. Contrepois, C. Carbon, and P. Yeni. 1987. Protection of mice against experimental cryptococcosis by anti-Cryptococcus neoformans monoclonal antibody. Infect. Immun. 55:749-752.
13. Yuan, R., A. Casadevall, G. Spira, and M.D. Scharff. 1995. Isotype switching from IgG3 to IgG1 converts a nonprotective murine antibody to Cryptococcus neoformans into a protective antibody. J. Immunol. 154:1810-1816.
14. Nussbaum, G., R.R. Yuan, A. Casadevall, and M.D. Scharff. 1996. Immunoglobulin G3 blocking antibodies to the fungal pathogen Cryptococcus neoformans. J. Exp. Med. 183:1905-1909.
15. Mukherjee, J., A. Casadevall, and M.D. Scharff. 1993. Molecular characterization of the humoral responses to Cryptococcus neoformans infection and glucuronoxylomannan-tetanus toxoid conjugate immunization. J. Exp. Med. 177:1105-1116.
16. Cherniak, R., L.C. Morris, T. Belay, E.D. Spitzer, and A. Casadevall. 1995. Variation in the structure of glucuronoxylomannan in isolates from patients with recurrent cryptococcal meningitis. Infect. Immun. 63:1899-1905.
17. Mukherjee, J., M.D. Scharff, and A. Casadevall. 1992. Protective murine monoclonal antibodies to Cryptococcus neoformans. Infect. Immun. 60:4534-4541.
18. L usage in polysaccharide binding antibodies. J. Exp. Med. 174: 151-160.
19. Scott, J.K., and G.P. Smith. 1990. Searching for peptide ligands with an epitope library. Science (Wash. DC). 249: 386-390.
20. Valadon, P., G. Nussbaum, L.F. Boyd, D.H. Margulies, and M.D. Scharff. 1996. Peptide libraries define the fine specificity of anti-polysaccharide antibodies to Cryptococcus neoformans. J. Mol. Biol. 261:11-22.
21. Parmley, S.F., and G.P. Smith. 1988. Antibody-selectable filamentous fd vectors: affinity purification of target genes. Gene (Amst.) 73:305-318.
22. Smith, G.P., and J.K. Scott. 1993. Libraries of peptides and proteins displayed on filamentous phage. Methods Enzymol. 217:228-257.
23. Sanger, F., S. Nicklen, and A.R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA. 74:5463-5467.
24. Valadon, P., and M.D. Scharff. 1996. Enhancement of ELISAs for screening peptides in epitope phage display library. J. Immunol. Methods. 197:171-179.
25. Mukherjee, S., M. Feldmesser, and A. Casadevall. 1996. J774 murine macrophage-like cell interactions with Cryptococcus neoformans in the presence and absence of opsonins. J. Inject. Dis. 173:1222-1231.
26. Fries, B.C., F. Chen, B.C. Currie, and A. Casadevall. 1996. Karyotype instability in Cryptococcus neoformans infection. J. Clin. Microbiol. 34:1531-1534.
27. Casadevall, A., J. Mukherjee, and M.D. Scharff. 1992. Monoclonal antibody based ELISAs for cryptococcal polysaccharide. J. Immunol. Methods. 154:27-35.
28. Bhattacharjee, A.K., J.E. Bennett, and C.P. Glaudemans. 1984. Capsular polysaccharides of Cryptococcus neoformans. Rev. Infect. Dis. 6:619-624.
29. Hartung, H.P., and U. Hadding. 1983. Synthesis of complement by macrophages and modulation of their functions through complement activation. Springer Semin. Immunopathol. 6:283-326.
30. Kozel, T.R., B. Highison, and C.J. Stratton. 1984. Localization on encapsulated Cryptococcus neoformans of serum components opsonic for phagocytosis by macrophages and neutrophils. Infect. Immun. 43:574-579.
31. Kozel, T.R. 1996. Activation of the complement system by pathogenic fungi. Clin. Microbiol. Rev. 9:34-46.
32. Lucisano Valim, Y.M., and P.J. Lachmann. 1991. The effect of antibody isotype and antigenic epitope density on the complement-fixing activity of immune complexes: a systematic study using chimaeric anti-NIP antibodies with human Fc regions. Clin. Exp. Immunol. 84:1-8.
33. Casadevall, A., J. Mukherjee, S.J. Devi, R. Schneerson, J.B. Robbins, and M.D. Scharff. 1992. Antibodies elicited by a Cryptococcus neoformans-tetanus toxoid conjugate vaccine have the same specificity as those elicited in infection. J. Infect. Dis. 165:1086-1093.