Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis

Synapse

Volumn 45, Issue 4, 2002, Pages 245-249

  Tomiyama, Masahiko ^a,b   Rodríguez Puertas, Rafael ^c   Cortés, Roser ^a   Pazos, Angel ^b   Palacios, José M ^a   Mengod, Guadalupe ^a,d  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b HIROSAKI UNIVERSITY   (Japan)

^c UNIVERSITY OF CANTABRIA   (Spain)

^d INST D INVESTIGACIONS B   (Spain)

Author keywords

Excitotoxicity; Flip; Flop; Glutamate; Motor neuron disease; Neurodegenerative disease

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; EXCITOTOXIN; GLUTAMIC ACID; RECEPTOR SUBUNIT;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CALCIUM TRANSPORT; CLINICAL ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; FEMALE; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALE; MOTOR NEURON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; RNA TRANSCRIPTION; SPINAL CORD; SPINAL CORD MOTONEURON; SPINAL CORD VENTRAL HORN;

ADULT; AGED; AGED, 80 AND OVER; AMYOTROPHIC LATERAL SCLEROSIS; FEMALE; HUMANS; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; MOTOR NEURONS; RECEPTORS, AMPA; RNA SPLICING; RNA, MESSENGER; SPINAL CORD;

EID: 0037105935     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/syn.10098     Document Type: Article

References (35)

1. Desensitization of AMPA receptors limits the amplitude of EPSPs and the excitability of motoneurons of the rat isolated spinal cord
2. Cultured motor neurons possess calcium-permeable AMPA/kainate receptors
3. Review: Neurotransmitter receptors. II. AMPA and kainate receptors
4. AMPA receptor desensitization predicts the selective vulnerability of cerebellar Purkinje cells to excitotoxicity
5. Fasting plasma and CSF amino acid levels in amyotrophic lateral sclerosis: A subtype analysis
6. Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro
7. AMPA exposures induce mitochondrial Ca(2+) overload and ROS generation in spinal motor neurons in vitro
8. Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors
9. 2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS
10. Cloned glutamate receptors
11. 2+ permeability of KA-AMPA - Gated glutamate receptor channels depends on subunit composition
12. Kainic acid induces early and delayed degenerative neuronal changes in rat spinal cord
13. Motor neuron degeneration induced by excitotoxin agonists has features in common with those seen in the SOD-1 transgenic mouse model of amyotrophic lateral sclerosis
14. Correlation between kinetics and RNA splicing of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in neocortical neurons
15. Amyotrophic lateral sclerosis: Glutamate dehydrogenase and transmitter amino acids in the spinal cord
16. A molecular determinant for submillisecond desensitization in glutamate receptors
17. Abnormal glutamate metabolism in amyotrophic lateral sclerosis
18. The neuroexcitotoxic amino acids glutamate and aspartate are altered in the spinal cord and brain in amyotrophic lateral sclerosis
19. Excitotoxicity hypothesis
20. Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis
21. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
22. Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity
23. The TINS/TiPS lecture. The molecular biology of mammalian glutamate receptor channels
24. Glutamate, excitotoxicity and amyotrophic lateral sclerosis
25. CSF and plasma amino acid levels in motor neuron disease: Elevation of CSF glutamate in a subset of patients
26. Low expression of GluR2 AMPA receptor subunit protein by human motor neurons
27. RNA editing in brain controls a determinant of ion flow in glutamate-gated channels
28. Reduction of GluR2 RNA editing, a molecular change that increases calcium influx through AMPA receptors, selective in the spinal ventral gray of patients with amyotrophic lateral sclerosis
29. Differential regional distribution of AMPA receptor subunit messenger RNAs in the human spinal cord as visualized by in situ hybridization
30. AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability
31. AMPA receptor calcium permeability, GluR2 expression, and selective motoneuron vulnerability
32. Subcellular localization of calcium-permeable AMPA receptors in spinal motoneurons
33. Analysis of AMPA receptor subunit mRNA expression in control and ALS spinal cord
34. Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors: A molecular determinant of selective vulnerability in amyotrophic lateral sclerosis
35. Blockade of desensitization augments quisqualate excitotoxicity in hippocampal neurons