Identification of key residues responsible for enzymatic and platelet-aggregation-inhibiting activities of acidic phospholipase a2s from Agkistrodon halys Pallas

Journal of Natural Toxins

Volumn 10, Issue 1, 2001, Pages 43-55

  Liu, X L ^a   Wu, X F ^a   Zhou, Y C ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AGKISTRODON HALYS; ENZYME ACTIVITY; ENZYME DENATURATION; ENZYME PURIFICATION; ENZYME STRUCTURE; ESCHERICHIA COLI; EXPRESSION VECTOR; GENE INSERTION; GENETIC STRAIN; MUTANT; PHOSPHOLIPASE A2; RECOMBINANT ENZYME; SITE DIRECTED MUTAGENESIS;

ADULT; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CROTALID VENOMS; ESCHERICHIA COLI; GENETIC VECTORS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHOLIPASES A; PLATELET AGGREGATION; STRUCTURE-ACTIVITY RELATIONSHIP;

AGKISTRODON; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; GLOYDIUS HALYS;

EID: 0035112017     PISSN: 10588108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. 2 from Naja naja naja and Vipera russelli snake venoms
2. 2-like precursor
3. 2 from the venom of Agkistrodon halys Pallas
4. Cobra venom careliotoxin (Cytotoxin) isoforms and neurotoxin: Comparative potency of protein kinase C inhibition and cancer cell cytotoxicity and modes of enzyme inhibition
5. 2, anticoagulant and myotoxic activities
6. 2 isolated from Lachesis muta (Bushmaster) snake venom
7. Isolation and characterization of two phospholipase A's from the Agkistrodon halys blohoff II
8. 2 expressed from a synthetic gene in Escherichia coli
9. 2 homolog from the venom of Trimeresurus mucrosquamatus
10. 2 gene from Agkistrodon halys Pallas
11. 2-II from Agkistrodon halys Pallas
12. 2II from Agkistrodon acutus
13. A comparative study of the function of phospholipases A2 from Agkistrodon acutus
14. Colorimetric ultramicro method for the determination of free fatty acids
15. Protein platelet aggregation inhibitor purified from Agkistrodon halys (Mamushi) snake venom
16. 2 from Agkistrodon halys Pallas venom, and its expression in E. coli
17. 2 from bovine pancreas and Crotalus atrox venom
18. 2
19. 2 that induces platelet aggregation
20. 2
21. 2 from the venom of Agkistrodon halys Pallas at 2.0 Å resolution
22. 2 from the venom of Agkistrodon halys Pallas
23. 2
24. 2
25. The bioactive phospholipid, lysophosphatidylcholine, induces cellular effects via G-protein-dependent activation of adenylyl cyclase
26. 2 from the venom of Agkistrodon halys Pallas
27. 2 from Agkistrodon halys Pallas
28. Structure of a basic phospholipase A2 from Agkistrodon halys Pallas at 2.13 Å resolution