The human IL-3 locus is regulated cooperatively by two NFAT-dependent enhancers that have distinct tissue-specific activities

Journal of Immunology

Volumn 169, Issue 4, 2002, Pages 1876-1886

  Hawwari, Abbas ^a   Burrows, Joanna ^a   Vadas, Mathew A ^a   Cockerill, Peter N ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CD34 ANTIGEN; CYCLOSPORIN A; DEOXYRIBONUCLEASE; INTERLEUKIN 3; PHOSPHOTRANSFERASE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; BINDING SITE; BONE MARROW CELL; CELL LINEAGE; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA BINDING; DNA SEQUENCE; ENHANCER REGION; EOSINOPHIL; EVOLUTION; GENE CONTROL; GENE EXPRESSION; GENE LOCUS; GENE MAPPING; HEMATOPOIESIS; HUMAN; HUMAN CELL; MAST CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TISSUE SPECIFICITY;

EID: 0037103135     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.4.1876     Document Type: Article

References (43)

1. Hemopoietic cell growth factors and their receptors
2. Regulation of granulocyte-macrophage colony-stimulating factor and interleukin-3 expression
3. Cytokines in haematopoiesis
4. The human genes for GM-CSF and IL-3 are closely linked in tandem on chromosome 5
5. Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region
6. Expression of lymphokine genes in T cells
7. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
8. Functional diversity of helper T lymphocytes
9. Differentiation of human NK cells into NK1 and NK2 subsets
10. Reconstitution of T cell-specific transcription directed by composite NFAT/Oct elements
11. The granulocyte-macrophage colony-stimulating factor/interleukin-3 locus is regulated by an inducible cyclosporin A-sensitive enhancer
12. Human granulocytemacrophage colony-stimulating factor gene is autonomously regulated in vivo by an inducible tissue-specific enhancer
13. Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with cooperative interactions between AP-1 and NFATp/c
14. A T cell-specific enhancer in the interleukin-3 locus is activated cooperatively by Oct and NFAT elements within a DNase I hypersensitive site
15. Positive and negative elements regulate human interleukin 3 expression
16. Transcriptional regulation of interleukin-3 gene expression in T lymphocytes
17. Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein
18. Molecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the interleukin-3 promoter
19. Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter
20. Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3
21. Transcriptional regulation of interleukin-3 expression in megakaryocytes
22. Identification of DNasel hypersensitive sites within nuclei
23. Blast 2 sequences - A new tool for comparing protein and nucleotide sequences
24. Luciferase reporter gene vectors for analysis of promoters and enhancers
25. Generation of an improved luciferase reporter gene plasmid that employs a novel mechanism for high-copy replication
26. Immunoglobulin κ gene expression after stable integration. I. Role of the intronic MAR and enhancer in plasmacytoma cells
27. In vitro sensitivity of immature human mast cells to chemotherapeutic agents
28. Divergent molecular phenotypes of KG1 and KG1a cell lines
29. Regulation of granulocyte-macrophage colony-stimulating factor and E-selection expression in endothelial cells by cyclosporin A and the T cell transcription factor NFAT
30. Circadian transcription of the cholesterol 7α hydroxylase gene may involve the liver-enriched bZIP protein DBP
31. Regulation of GM-CSF gene transcription by core-binding factor
32. DNA-binding specificities of the GATA transcription factor family
33. Striking sequence similarity over almost 100 kilobases of human and mouse T-cell receptor DNA
34. Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-sequence comparisons
35. Regulatory anatomy of the murine interleukin-2 gene
36. NF-ATp: A transcription factor required for the co-ordinate induction of several cytokine genes
37. Redundant and unique roles of two enhancer elements in the TCRγ locus in gene regulation and γδ T cell development
38. Heirarchical interactions of control elements determine CD8α gene expression in subsets of thymocytes and peripheral T cells
39. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
40. Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLEO elements
41. Identification of transcription factor binding sites important in the regulation of the human interleukin-5 gene
42. Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo
43. Cyclosporin A and FK506 reduce interleukin-5 mRNA abundance by inhibiting gene transcription