Carbonyl reduction of the potential cytostatic drugs benfluron and 3,9-dimethoxybenfluron in human in vitro

Biochemical Pharmacology

Volumn 64, Issue 2, 2002, Pages 297-305

  Skálová, Lenka ^a   Nobilis, Milan ^b   Szotáková, Barbora ^a   Kondrová, Eliška ^a   Šavlík, Michal ^a   Wsól, Vladimír ^a   Pichard Garcia, Lydiane ^c   Maser, Edmund ^d  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b INSTITUTE OF MATHEMATICS   (Czech Republic)

^c CNRS   (France)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

11 Hydroxysteroid dehydrogenase; Carbonyl reductase; Chemotherapy; Drug resistance; Human hepatocytes; Structure metabolism relationship

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 3,9 DIMETHOXYBENFLURON; ANTINEOPLASTIC AGENT; BENFLURON; CARBONYL REDUCTASE; CYTOSTATIC AGENT; UNCLASSIFIED DRUG;

AGED; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG INACTIVATION; DRUG METABOLISM; ENZYME PURIFICATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; LIVER CYTOSOL; LIVER MICROSOME; MALE; PRIORITY JOURNAL; REDUCTION;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ALCOHOL OXIDOREDUCTASES; ANTINEOPLASTIC AGENTS; CELLS, CULTURED; FLUORENES; HEPATOCYTES; HUMANS; HYDROXYSTEROID DEHYDROGENASES; OXIDATION-REDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBCELLULAR FRACTIONS;

EID: 0037099314     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01068-7     Document Type: Article

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