Structure-activity relationship of neurokinin A(4-10) at the human tachykinin NK2 receptor: The effect of amino acid substitutions on receptor affinity and function

Biochemical Pharmacology

Volumn 63, Issue 12, 2002, Pages 2181-2186

  Warner, Fiona J ^a   Miller, Robert C ^b   Burcher, Elizabeth ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b Aoris Nova   (Australia)

Author keywords

Circular muscle; Human colon; Neurokinin A; NK2 receptor; Radioligand binding; Structure activity

Indexed keywords

AMINO ACID; LEUCINE; LYSINE; NEUROKININ 2 RECEPTOR; NEUROKININ A [4-10]; NEUROKININ DERIVATIVE; NOLPITANTIUM; SERINE;

ADULT; AGED; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CLINICAL ARTICLE; COLON; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG POTENCY; DRUG RECEPTOR BINDING; FEMALE; HUMAN; HUMAN TISSUE; INTESTINE MUSCLE; LIGAND BINDING; MALE; METHYLATION; PRIORITY JOURNAL; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; ANALYSIS OF VARIANCE; HUMANS; JEJUNUM; NEUROKININ A; PEPTIDE FRAGMENTS; RADIOLIGAND ASSAY; RECEPTORS, NEUROKININ-2; STATISTICS; STRUCTURE-ACTIVITY RELATIONSHIP; TRACHEA;

EID: 0037098269     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01014-6     Document Type: Article

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