Structure-activity relationships of neurokinin A (4-10) at the human tachykinin NK2 receptor: The role of natural residues and their chirality

Biochemical Pharmacology

Volumn 61, Issue 1, 2001, Pages 55-60

  Warner, Fiona ^a   Mack, Philip ^b   Comis, Alfio ^c   Miller, Robert ^d   Burcher, Elizabeth ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b Migenix Inc   (United States)

^c UNIVERSITY OF WESTERN SYDNEY   (Australia)

^d Aoris Nova   (Australia)

Author keywords

Human colon circular muscle; Neurokinin A; NK2 receptor; Radioligand binding; Retro inverso; Structure activity

Indexed keywords

NEUROKININ; NEUROKININ 2 RECEPTOR; NEUROKININ A [4-10];

AGED; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CHIRALITY; DRUG ACETYLATION; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; ENANTIOMER; FEMALE; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

AGED; AGED, 80 AND OVER; ALANINE; AMINO ACID SUBSTITUTION; BINDING, COMPETITIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MIDDLE AGED; MOLECULAR CONFORMATION; MUSCLE, SMOOTH; NEUROKININ A; PEPTIDE FRAGMENTS; PEPTIDES; RADIOLIGAND ASSAY; RECEPTORS, NEUROKININ-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035189284     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00516-5     Document Type: Article

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