Characterization of the [125I]-neurokinin A binding site in the circular muscle of human colon

British Journal of Pharmacology

Volumn 127, Issue 5, 1999, Pages 1105-1110

  Warner, Fiona J ^c   Comis, Alfio ^a   Miller, Robert C ^b   Burcher, Elizabeth ^c  

^a UNIVERSITY OF WESTERN SYDNEY   (Australia)

^b Memjet Australia Pty Ltd   (Australia)

^c NONE

Author keywords

Circular muscle; Human colon; Radioligand binding; Tachykinin NK2 receptor; Tachykinins; 125I NKA

Indexed keywords

ACETYLLEUCYLASPARTYLGLUTAMINYLTRYPTOPHYLPHENYLALANYLGLYCINAMIDE; BENZOYLALANYLALANYL DEXTRO TRYPTOPHYLPHENYLALANYL DEXTRO PROLYLPROLYLNORLEUCINAMIDE; MEN 10627; NEPADUTANT; NEUROKININ 2 RECEPTOR; NEUROKININ A; NEUROKININ A [4-10][5 TYROSINE 6,8,9 DEXTRO TRYPTOPHAN 10 LYSINE]; NEUROKININ B; NEUROPEPTIDE GAMMA; NOLPITANTIUM; SAREDUTANT; SENKTIDE; SUBSTANCE P; TACHYKININ RECEPTOR AGONIST; TACHYKININ RECEPTOR ANTAGONIST; PROTEINASE INHIBITOR;

ADULT; AGED; ARTICLE; BINDING SITE; CLINICAL ARTICLE; COLON; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; INTESTINE MUSCLE; ISOTOPE LABELING; MALE; PRIORITY JOURNAL; RECEPTOR AFFINITY; BINDING COMPETITION; KINETICS; METABOLISM; RADIOASSAY; SMOOTH MUSCLE;

BINDING SITES; BINDING, COMPETITIVE; COLON; HUMANS; KINETICS; MUSCLE, SMOOTH; NEUROKININ A; PROTEASE INHIBITORS; RADIOLIGAND ASSAY; RECEPTORS, NEUROKININ-2;

EID: 0033158969     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702648     Document Type: Article

References (25)

1. BÅRTHO, L. & HOLZER, P. (1985). Search for a physiological role of substance P in gastrointestinal motility. Neuroscience, 16, 1-32.
2. BYLUND, D.B. & YAMAMURA, H.I. (1990). Methods for receptor binding. In Methods in neurotransmitter receptor analysis. ed. Yamamura, H.I. pp. 1-35. New York: Raven Press.
3. 2 receptor. Neuropeptides, 20, 79-82.
4. COSTA, M., FURNESS, J.B., PULLIN, C.O. & BORNSTEIN, J. (1985). Substance P enteric neurons mediate non-cholinergic transmission to the circular muscle of the guinea-pig intestine. Naunyn Schmied. Arch. Pharmacol., 328, 446-453.
5. 2 receptor modulating motor responses of human colonic muscle strips. Br. J. Pharmacol., 124, 1321-1327.
6. 2) receptor. Life Sci. Pharmacol. Lett., 50, PL101-PL106.
7. GATES, T.S., ZIMMERMAN, R.P., MANTYH, C.R., VIGNA, S.R., MAGGIO, J.E., WELTON, M.L., PASSARO, E.P. & MANTYH, P.W. (1989). Substance P and substance K receptor binding sites in the human gastrointestinal tract: localisation by autoradiography. Peptides, 9, 1207-1212.
8. GERAGHTY, D.P., MUSSAP, C.J. & BURCHER, E. (1992). Radioiodinated substance P, neurokinin A and eledoisin bind predominantly to NKI receptors in guinea pig lung. Mol. Pharmacol., 41, 147-153.
9. 2 receptor subtype. Eur. J. Pharmacol., 203, 365-370.
10. GRIDER, J.R. (1989). Identification of neurotransmitters regulating intestinal peristaltic reflex in humans. Gastroenterology, 97, 1414-1419.
11. HOLZER, P. & HOLZER-PETSCHE, U. (1997a). Tachykinins in the gut. Part I. Expression, release and motor function. Pharmacol. Ther., 73, 173-217.
12. HOLZER, P. & HOLZER-PETSCHE, U. (1997b). Tachykinins in the gut. Part II. Roles in neural excitation, secretion and inflammation. Pharmacol. Ther., 73, 219-263.
13. MAGGI, C.A., PATACCHINI, R., ROVERO, P. & GIACHETTI, A. (1993). Tachykinin receptors and receptor antagonists. J. Auton. Pharmacol., 13, 23-93.
14. MAGGI, C.A., THEODORSSON, P., SANTICOLO, P., PATACCHINI, R., BARBANTI, G., TURINI, D., RENZI, D. & GIACHETTI, A. (1990). Motor response of the human isolated colon to capsaicin and its relationship to release of vasoactive intestinal polypeptide. Neuroscience, 39, 833-842.
15. 1 are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease. Proc. Natl. Acad. Sci. U.S.A., 85, 3235-3239.
16. MARKUS, I., SHANG, F., LIU, L., LUBOWSKI, D.Z. & BURCHER, E. (1998). Autoradiographic localization and characterization of tachykinin NK-1 receptors in human sigmoid colon. 3rd Australian Peptide Conference, Laguna Quays, Australia.
17. MUSSAP, C.J. & BURCHER, E. (1990). Characterization and autoradiographic localization of tachykinin receptors in rat gastric fundus. J. Pharmacol. Exp. Ther., 266, 1043-1053.
18. MUSSAP, C.J., GERAGHTY, D.P. & BURCHER, E. (1993). Tachykinin receptors: a radioligand binding perspective. J. Neurochem., 60, 1987-2009.
19. 2 receptors in dog urinary bladder. J. Pharmacol. Exp. Ther., 279, 423-434.
20. 2 receptor antagonists in the human isolated ileum and colon. Neuropeptides, 31, 71-77.
21. PORTER, A.J., WATTCHOW, D.A., BROOKES, S.J., SCHEMANN, M. & COSTA, M. (1996). Choline acetyltransferase immunoreactivity in the human small and large intestine. Gastroenterology, 111, 401-408.
22. 2 receptors in the hamster urinary bladder. Naunyn-Schmied. Arch. Pharmacol., 345, 51-56.
23. WATTCHOW, D.A., FURNESS, J.B. & COSTA, M. (1988). Distribution and co-existence of peptides in nerve fibers of the external muscle of the human gastrointestinal tract. Gastroenterology, 95, 32-41.
24. WATTCHOW, D.A., PORTER, A.J., BROOKS, S.J.H. & COSTA, M. (1997). The polarity of neurochemically defined myenteric neurons in the human colon. Gastroenterology, 113, 497-506.
25. 2 receptors in human urinary bladder. J. Urol., 153, 1688-1692.