Resistance of HepG2 cells against the adverse effects of ethanol related to neutral lipid and phospholipid metabolism

Biochemical Pharmacology

Volumn 63, Issue 8, 2002, Pages 1485-1490

  Jiménez López, José M ^a   Carrasco, María P ^a   Segovia, Josefa L ^a   Marco, Carmen ^a  

^a UNIVERSITY OF GRANADA   (Spain)

Author keywords

Ethanol; HepG2 cells; Lipid metabolism

Indexed keywords

ACETYL COENZYME A; ALCOHOL; CARBON 14; GLYCEROL; LIPID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID; TRIACYLGLYCEROL; TRITIUM;

ALCOHOL METABOLISM; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; HEPATOMA CELL; HUMAN; HUMAN CELL; LIPID DEGRADATION; LIPID METABOLISM; LIPID PEROXIDATION; LIPID TRANSPORT; LIVER CELL; LIVER TOXICITY; LONG TERM EXPOSURE; PHOSPHOLIPID METABOLISM; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; RADIOACTIVITY;

ANALYSIS OF VARIANCE; ETHANOL; HUMANS; PHOSPHOLIPIDS; TUMOR CELLS, CULTURED;

EID: 0037090940     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)00896-1     Document Type: Article

References (29)

1. Alcohol and lipids
2. Hepatotoxicity due to mitochondrial dysfunction
3. Mechanisms of alcoholic liver injury
4. Stimulation by ethanol of triglyceride synthesis in fasted rat hepatocytes is dependent on the increase of glycerol 3-phosphate levels
5. Metabolic consequences of ethanol
6. 4502E1: Its physiological and pathological role
7. Studies on phospholipid biosynthesis in hepatocytes from alcoholic rats by using radiolabeled exogenous precursors
8. Chronic ingestion of ethanol stimulates lipogenic response in rat hepatocytes
9. Evidence of differential effects produced by ethanol on specific phospholipid biosynthetic pathways in rat hepatocytes
10. Incorporation of exogenous precursors into neutral lipids and phospholipids in rat hepatocytes: Effect of ethanol in vitro
11. HepG2 cells as a resource for metabolic studies: Lipoprotein, cholesterol, and bile acids
12. Lipid balance in HepG2 cells: Active synthesis and impaired mobilization
13. Establishment of a recombinant hepatic cell line stably expressing alcohol dehydrogenase
14. A rapid method for total lipid extraction and purification
15. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
16. 450-dependent activity with similar properties towards substrate and inhibitors and different properties from those induced by classical inducers
17. In vitro assessment of the ethanol-induced hepatotoxicity on HepG2 cell line
18. Ethanol increases content and activity of human cytochrome P450 2E1 in a transduced HepG2 cell line
19. CYP2E1 overexpression in HepG2 cells induces glutathione synthesis by transcriptional activation of gamma-glutamylcysteine synthetase
20. Ethanol-related cytotoxicity catalysed by CYP2E1-dependent generation of reactive oxygen intermediates in transduced HepG2 cells
21. Differential effects of eicosapentaenoic acid on glycerolipid and apolipoprotein B metabolism in primary human hepatocytes compared to HepG2 cells and primary rat hepatocytes
22. Effect of ethanol on the synthesis and secretion of apoA-I- and apoB-containing lipoproteins in HepG2 cells
23. Biosynthesis of medium-chain triacylglycerols and phospholipids by HepG2 cells
24. Effects of ethanol intake on lipid metabolism in the lactating rat
25. Role of the cellular redox state in modulating acute ethanol toxicity in isolated hepatocytes
26. Mechanism by which ethanol inhibits phosphatidylcholine biosynthesis in human leukemic monocyte-like U937 cells
27. An in vitro model of ethanol-dependent liver cell injury
28. Differential in vitro effects of ethanol on glycerolipid acylation and biosynthesis in rat reticulocytes
29. Effect of ethanol on lipoprotein secretion in two human hepatoma cell lines, HepG2 and Hep3B