Feline immunodeficiency virus infection is characterized by B7+CTLA4+ T cell apoptosis

Journal of Infectious Diseases

Volumn 185, Issue 8, 2002, Pages 1077-1093

  Tompkins, Mary B ^a   Bull, Marta E ^a   Dow, Janet L ^a   Ball, Judith M ^b   Collisson, Ellen W ^b   Winslow, Barbara J ^c   Phadke, Anagha P ^b   Vahlenkamp, Thomas W ^a   Tompkins, Wayne A ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c Schering Plough Anim Hlth Corp   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; PROTEIN ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; FELINE IMMUNODEFICIENCY VIRUS; FLOW CYTOMETRY; IMMUNE DEFICIENCY; LYMPH NODE CELL; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; VIRUS INFECTION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, CD86; ANTIGENS, DIFFERENTIATION; APOPTOSIS; CATS; FELINE ACQUIRED IMMUNODEFICIENCY SYNDROME; IMMUNOCONJUGATES; IN SITU NICK-END LABELING; MEMBRANE GLYCOPROTEINS; T-LYMPHOCYTES;

EID: 0037090115     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/339847     Document Type: Article

References (66)

1. Small animal model of AIDS and the feline immunodeficiency virus
2. Pathogenesis of human immunodeficiency virus infection
3. AIDS as immune system activation. II. The panergic imnesia hypothesis
4. Common epitope in human immunodeficiency virus (HIV) I-GP41 and HLA class II elicits immunosuppressive autoantibodies capable of contributing to immune dysfunction in HIV I-infected individuals
5. + cell depletio
6. Immunological abnormalities in the natural history of HIV infection: Mechanisms and clinical relevance
7. Analysis of apoptosis in lymph nodes of HIV-infected persons: Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden
8. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes
9. Spontaneous programmed cell death (PCD) process of lymphocytes of FIV-infected cats: Cellular targets and modulation
10. Apoptotic fraction in lymphoid tissue of FIV-infected SPF cats
11. Biochemical pathways of caspase activation during apoptosis
12. Tumor necrosis factor receptor and Fas signaling mechanisms
13. CD28 and apoptosis
14. CD28/B7 costimulation: A review
15. Decreased mitogen responsiveness and elevated tumor necrosis factor production in cats shortly after feline immunodeficiency virus infection
16. T cell clonal anergy
17. The role of B7 costimulation in T-cell immunity
18. Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation
19. Blockade of the CD28 costimulatory pathway: A means to induce tolerance
20. Is CTLA-4 a master switch for peripheral T cell tolerance?
21. CTLA-4: A negative regulator of autoimmune disease
22. CTLA-4 can function as a negative regulator of T cell activation
23. + T lymphocytes induced by CTLA-4 crosslinking
24. B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2
25. Selective induction of B7/BB-1 on interferon-gamma stimulated monocytes: A potential mechanism for amplification of T cell activation through the CD28 pathway
26. Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand
27. Analysis of CD80 and CD86 expression on peripheral blood B lymphocytes reveals increased expression of CD86 in lupus patients
28. Elevated expression of CD80 (B7/BB1) and other accessory molecules on synovial fluid mononuclear cell subsets in rheumatoid arthritis
29. Expression of functional B7 and CTLA4 on rheumatoid synovial T cells
30. The B7 adhesion molecule is expressed on activated human T cells: Functional involvement in T-T cell interactions
31. CD80 and CD86 costimulatory molecules on circulating T cells of HIV infected individuals
32. B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: Implications for induction of antitumor immunity to T cell tumors
33. Failure of correlation between B7 expression and activation of interleukin-2-secreting T cells
34. In vivo lymphocyte tropism of feline immunodeficiency virus
35. Development of clinical disease in cats experimentally infected with feline immunodeficiency virus
36. Early events in the immunopathogenesis of feline retrovirus
37. + antiviral response that correlates with reduction of cell-associated virus
38. Elevated interleukin-10-to-interleukin-12 ratio in feline immunodeficiency virus-infected cats predicts loss of type 1 immunity to Toxoplasma gondii
39. Feline immunodeficiency virus predisposes cats to acute generalized toxoplasmosis
40. Induction of IL-2 and lymphokine activated killer cells in the cat
41. Characterization of monoclonal antibodies to feline T lymphocytes and their use in the analysis of lymphocyte tissue distribution in the cat
42. + phenotype mediating antiviral activity in feline immunodeficiency virus-infected cats is characterized by reduced surface expression of the CD8 β chain
43. Molecular cloning and expression of feline CD28 and CTLA-4 cDNA
44. Sequence analyses of feline B7 costimulatory molecules
45. The molecular biology of swinepox virus. I. A characterization of the viral DNA
46. Vaccinia virus expression vectors
47. Vaccinia virus expression vector: Co-expression of beta-galactosidase provides visual screening of recombinant virus plaques
48. Recombinant vaccinia viruses: Design, generation, and isolation
49. Development of a CD28 receptor binding-based screen and identification of a biologically active inhibitor
50. Proviral burden and infection kinetics of feline immunodeficiency virus in lymphocyte subsets of blood and lymph node
51. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation
52. Immunohistochemical characterisation of macrophages in human liver and gastrointestinal tract: Expression of CD4, HLA-DR, OKM1, and the mature macrophage marker 25F9 in normal and diseased tissue
53. - subclasses of dendritic cells direct the development of distinct T helper cells in vivo
54. A standardized gating technique for the generation of flow cytometry data for normal canine and normal feline blood lymphocytes
55. A biochemical characterization of feline MHC products: Unusually high expression of class II antigens on peripheral blood lymphocytes
56. Altered surface antigen expression on peripheral blood mononuclear cells in cats infected with feline immunodeficiency virus
57. Persistent upregulation of MHC class II antigen expression on T-lymphocytes from cats experimentally infected with feline immunodeficiency virus
58. Progressive expansion of an L-selectin-negative CD8 cell with anti-feline immunodeficiency virus (FIV) suppressor function in the circulation of FIV-infected cats
59. Antigen presentation by T cells inhibits IL-2 production and induces IL-4 release due to altered cognate signals
60. Regulation of surface and intracellular expression of CTLA4 on mouse T cells
61. + T cells
62. Direct and indirect mechanisms mediating apoptosis during HIV infection: Contribution to in vivo CD4 T cell depletion
63. Activated T cells can induce high levels of CTLA-4 expression on B cells
64. Acquisition of CD80 (B7-1) by T cells
65. + T cells in HIV infection
66. + cells from HIV-infected persons