C1-inhibitor for prophylaxis of xenograft rejection after pig to cynomolgus monkey kidney transplantation

Transplantation

Volumn 73, Issue 5, 2002, Pages 688-694

  M Hecker, Jens ^a   Lorenz, Ralf ^a   Appiah, Richard ^a   Vangerow, Burkhard ^a   Loss, Martin ^a   Kunz, Robert ^a   Schmidtko, Jan ^a   Mengel, Michael ^a   Klempnauer, J̈rgen ^a   Piepenbrock, Siegfried ^a   Dickneite, Gerhard ^b   Neidhardt, Helge ^b   Rückoldt, Horst ^a   Winkler, Michael ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C1S INHIBITOR; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; STEROID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; MONKEY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; SEPTICEMIA; SWINE; XENOGRAFT; XENOTRANSPLANTATION;

EID: 0037087620     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200203150-00006     Document Type: Article

References (41)

1. Complement-fixing elicited antibodies are a major component in the pathogenesis of xenograft rejection
2. Immunopathology of hyperacute xenograft rejection in a swine-to-primate model
3. Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients
4. The role of complement in transplantation
5. Acute vascular rejection
6. Expression of human decay accelerating factor of membrane cofactor protein genes on mouse cells inhibits lysis by human complement
7. The generation of transgenic pigs as potential organ donors for humans
8. Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection
9. Long-time survival of cynomolgus monkeys following pig-to-primate kidney xenotransplantation using h-DAF transgenic donor organs
10. Discordant organ xenotransplantation in primates: World experience and current status
11. Acute vascular rejection is associated with systemic complement activation in a pig-to-primate kidney xenograft model
12. C1-INH for treatment of acute vascular xenograft rejection in cynomolgus recipients of hDAF transgenic porcine kidneys
13. Pig to monkey bone marrow and kidney xenotransplantation
14. Influence of cold ischemia time, pretransplant anti-porcine antibodies, and donor/recipient size matching on hyperacute graft rejection after discordant porcine to cynomolgus kidney transplantation
15. Inhibition of complement, evoked antibody, and cellular response prevents rejection of pig-to-primate cardiac xenografts
16. Pig-to-primate cardiac xenotransplantation and cyclophosphamide therapy
17. Use of tacrolimus (FK 506) and antimetabolites as immunosuppressants for xenotransplantation across closely related rodent species
18. C1-Inhibitor prevents capillary leakage after thermal trauma
19. Septic shock after liver transplantation for Caroli's disease: Clinical improvement after treatment with C1-esterase inhibitor
20. Growth of porcine kidneys in their native and xenograft environment
21. Beyond hyperacute rejection: Strategies for development of pig to primate xenotransplantation
22. Absence of hyperacute rejection and preservation of function in hDAF transgenic pig kidneys exposed to prolonged cold ischemia
23. Factors determinating the onset of hyperacute graft rejection following discordant porcine to cynomolgus monkey kidney xenotranspantation
24. C1-esterase inhibitor: An anti-inflammatory agent and its potential use in the treatment of diseases other than hereditary angioedema
25. C1-inhibitor attenuates hyperacute rejection and inhibits complement, leukocyte and platelet activation in an ex vivo pig-to-human perfusion model
26. Prevention of complement-mediated activation of xenogeneic endothelial cells in an in vitro model of xenograft hyperacute rejection by C1 inhibitor
27. Protection of porcine endothelial cells from complement-mediated cytotoxicity by the human complement regulators CD59, C1 inhibitor, and soluble complement receptor type 1. Analysis in a pig-to-human in vitro model relevant to hyperacute xenograft rejection
28. Effect of continuous complement inhibition using soluble complement receptor type 1 on survival of pig-to-primate cardiac xenografts
29. The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts
30. Inhibition of complement, evoked antibody, and cellular response prevents rejection of pig-to-primate cardiac xenografts
31. Effect of repetitive high-dose treatment with soluble complement receptor type 1 and cobra venom factor on discordant xenograft survival
32. Cardioprotective effects of selective inhibition of the two complement activation pathways in myocardial ischemia and reperfusion injury
33. Intravital microscopic investigation of xenogeneic microcirculation and impact of complement depletion by cobra venom factor
34. Initial studies on the administration of C1-esterase inhibitor to patients with septic shock or with a vascular leak syndrome induced by interleukin-2 therapy
35. Inactivation of factor XIa in human plasma assessed by measuring factor XIa-protease inhibitor complexes: Major role for C1-inhibitor
36. Inhibition of human blood coagulation factor XIa by C-1 inhibitor
37. Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates
38. Disseminated intravascular coagulation in association with the delayed rejection of pig-to-baboon renal xenografts
39. Profound coagulopathy associated with pig-to-primate xenotransplantats: How many transgenes will be required to overcome this new barrier?
40. Long-term survival of nonhuman primates receiving life-supporting transgenic porcine kidney xenografts
41. Hyperacute xenograft rejection is not consistent after pig to primate solid organ transplantation