t(7;11)(p15;p15) chronic myeloid leukaemia developed into blastic transformation showing a novel NUP98/HOXA11 fusion

British Journal of Haematology

Volumn 116, Issue 1, 2002, Pages 170-172

  Suzuki, Akitaka ^a   Ito, Yoshikazu ^a   Sashida, Goro ^a   Honda, Seiko ^a   Katagiri, Tomoko ^a   Fujino, Takashi ^b   Nakamura, Takuro ^b   Ohyashiki, Kazuma ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b CANCER INSTITUTE   (Japan)

Author keywords

AML; CML; HOXA11; NUP98; t(7; 11)

Indexed keywords

HYBRID PROTEIN; NUCLEOPORIN 98; PROTEIN HOXA11; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLAST TRANSFORMATION; CASE REPORT; CHRONIC MYELOID LEUKEMIA; CLINICAL FEATURE; DISEASE COURSE; FEMALE; FOLLOW UP; GENE FUSION; HUMAN; LABORATORY TEST; PHYSICAL EXAMINATION; PRIORITY JOURNAL; PROTEIN ANALYSIS;

BLOTTING, SOUTHERN; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 7; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; LEUKEMIA, MYELOCYTIC, ACUTE; LEUKEMIA, MYELOID, PHILADELPHIA-NEGATIVE; MIDDLE AGED; NUCLEAR PORE COMPLEX PROTEINS; ONCOGENE PROTEINS, FUSION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSLOCATION, GENETIC;

EID: 0036164903     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2002.03246.x     Document Type: Article

References (9)

1. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9
2. Molecular heterogeneity of the NUP98/HOXA9 fusion transcript in myelodysplastic syndromes associated with t(7;11)(p15;p15)
3. 1 chromosome-negative chronic myelogenous leukemia
4. NUP98, HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice
5. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia
6. Translocation between chromosomes 7 and 11 in nonlymphocytic neoplasia
7. Reciprocal translocation involving the short arms of chromosomes 7 and 11, t(7p-;11p+), associated with myeloid leukemia with maturation
8. Chronic myelomonocytic leukemia with t(7;11)(p15;p15) and NUP98/HOXA9 fusion
9. Expression of the NUP98/HOXA9 fusion transcript in the blast crisis of Philadelphia chromosome-positive chronic myelogenous leukaemia with t(7;11) (p15;p15)