A masked NES in INI1/hSNF5 mediates hCRM1-dependent nuclear export: Implications for tumorigenesis

EMBO Journal

Volumn 21, Issue 1-2, 2002, Pages 31-42

  Craig, Errol ^a   Zhang, Zhi Kai ^a   Davies, Kelvin P ^a   Kalpana, Ganjam V ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

HSNF5; INI1; NES; Nuclear export; Tumor suppressor

Indexed keywords

AMINO ACID; INTEGRASE INTERACTOR 1; LEPTOMYCIN B; MUTANT PROTEIN; NUCLEAR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELL CYCLE; CELL LINE; CONTROLLED STUDY; DELETION MUTANT; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RHABDOID TUMOR; TUMOR SUPPRESSOR GENE;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; CELL CYCLE; CELL SIZE; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA, NEOPLASM; DNA-BINDING PROTEINS; FATTY ACIDS, UNSATURATED; HELA CELLS; HUMANS; KARYOPHERINS; MOLECULAR SEQUENCE DATA; MUTATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT FUSION PROTEINS; RHABDOID TUMOR; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS;

MAMMALIA; NES;

EID: 0037080819     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.1.31     Document Type: Article

References (45)

1. Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 protein
2. Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors
3. c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function
4. Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4
5. Nuclear export of the E1B 55 kDa and E4 34 kDa adenoviral oncoproteins mediated by a rev-like signal sequence
6. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest
7. CRM1 is an export receptor for leucine-rich nuclear export signals
8. The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88
9. CRM1 is responsible for intracellular transport mediated by the nuclear export signal
10. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
11. Frequent deletion of hSNF5/INI1, a component of the SWI/SNF complex, in chronic myeloid leukemia
12. Disruption of INI1 leads to peri-implantation lethality and tumorigenesis in mice
13. Transport of macromolecules between the nucleus and the cytoplasm
14. Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5
15. BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription
16. ATP-dependent remodeling and acetylation as regulators of chromatin fluidity
17. The murine SNF5/INII chromatin remodeling factor is essential for embryonic development and tumor suppression
18. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1
19. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region
20. The yeast SNF2/SWI2 protein has DNA-stimulated ATPase activity required for transcriptional activation
21. Regulation of a nuclear export signal by an adjacent inhibitory sequence: The effector domain of the influenza virus NS1 protein
22. Nucleocytoplasmic transport: The soluble phase
23. Two distinct mechanisms alter p53 in breast cancer: Mutation and nuclear exclusion
24. Structure-function analysis of integrase interactor 1/hSNF5L1 reveals differential properties of two repeat motifs present in the highly conserved region
25. A human protein with homology to Saccharomyces cerevisiae SNF5 interacts with the potential helicase hbrm
26. Nucleocytoplasmic transport: Signals, mechanisms and regulation
27. Evidence for a role of CRM1 in signal-mediated nuclear protein export
28. Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits
29. Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice
30. hSNF5/INI1 inactivation is mainly associated with homozygous deletions and mitotic recombinations in rhabdoid tumors
31. The C-terminal SET domains of ALL-I and TRITHORAX interact with the INI1 and SNRI proteins, components of the SWI/SNF complex
32. Nuclear exclusion of wild-type p53 in immortalized human retinoblastoma cells
33. Spectrum of hSNF5/INI1 somatic mutations in human cancer and genotype-phenotype correlations
34. Exportin 1 (Crm1p) is an essential nuclear export factor
35. A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
36. Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint
37. Cytoplasmic recruitment of INI and PML by incoming HIV preintegration complexes: An interference with the immediate early steps of viral replication
38. Nuclear export receptors: From importin to exportin
39. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer
40. Nuclear export of actin: A novel mechanism regulating the subcellular localization of a major cytoskeletal protein
41. Purification and biochemical heterogeneity of the mammalian SWI-SNF complex
42. Identification of a signal for rapid export of protcins from the nucleus
43. Leptomycin B is an inhibitor of nuclear export: Inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type I (HIV-1) Rev protein and Rev-dependent mRNA
44. Inhibition of HIV-1 virion production by a transdominant mutant of integrase interactor 1
45. 1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF