Blocking the CD80 and CD86 costimulation molecules: Lessons to be learned from animal models

Transplantation

Volumn 73, Issue 1 SUPPL., 2002, Pages

  Jonker, Margreet ^a   Ossevoort, Miriam A ^a   Vierboom, Michel ^a  

^a BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; B7 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND MONOCLONAL ANTIBODY; CD86 ANTIGEN; CYCLOSPORIN;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CLONAL ANERGY; CONFERENCE PAPER; EXPERIMENTAL MODEL; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; HUMAN CELL; IMMUNOREGULATION; IMMUNOSTIMULATION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; MONONUCLEAR CELL; NONHUMAN; ORGAN TRANSPLANTATION; PRIMATE; PRIORITY JOURNAL; RODENT; TRANSPLANTATION TOLERANCE;

EID: 0037080733     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200201151-00009     Document Type: Conference Paper

References (15)

1. The role of T-cell costimulatory activation pathways in transplant rejection
2. T cell costimulatory pathways: Promising novel targets for immunosuppression and tolerance induction
3. CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis
4. ICOS co-stimulatory receptor is essential for T-cell activation and function
5. ICOS is essential for effective T-helper-cell responses
6. Blocking CD40-CD154 and CD80/CD86-CD28 interactions during primary allogeneic stimulation results in T cell anergy and high IL-10 production
7. Blockade of CD86 and CD40 induces alloantigenspecific immunoregulatory T cells that remain anergic even after reversal of hyporesponsiveness
8. Prolonged skin graft survival by administration of anti-CD80 monoclonal antibody with cyclosporine A
9. Prevention of renal allograft rejection in primates by blocking the B7/CD28 pathway
10. Helper effector function of human T cells stimulated by anti-CD3 mAb can be enhanced by co-stimulatory signals and is partially dependent on CD40-CD40 ligand interaction
11. Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation
12. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
13. COS blockade by anti-CD40 and anti-CD86 prevents kidney graft rejection in rhesus monkeys