Characterization of a receptor for heat shock protein 70 on macrophages and monocytes

Biological Chemistry

Volumn 381, Issue 12, 2000, Pages 1165-1174

  Sondermann, H ^a   Becker, T ^a   Mayhew, M ^a   Wieland, F ^a   Hartl, F U ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

Antigen presentation; CD14; Chaperone; Receptor mediated endocytosis

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; BINDING PROTEIN; C PEPTIDE; CALRETICULIN; CANCER ANTIBODY; CD14 ANTIGEN; CD8 ANTIGEN; CELL SURFACE RECEPTOR; CHAPERONE; CYTOKINE; GLUTATHIONE TRANSFERASE; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HISTIDINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MEMBRANE RECEPTOR; PEPTIDE ANTIBODY; POLYPEPTIDE; PROPIDIUM IODIDE; RECOMBINANT PROTEIN; SODIUM CHLORIDE; TOLL LIKE RECEPTOR 4; TRANSFERRIN; TUMOR VACCINE; UNINDEXED DRUG; VIRUS ANTIGEN;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; BINDING AFFINITY; CELL ACTIVITY; CELL SPECIFICITY; CELL SURFACE; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; COMPLEX FORMATION; CONTROLLED STUDY; ENDOCYTOSIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN ISOLATION; PROTEIN LOCALIZATION; T LYMPHOCYTE SUBPOPULATION; TUMOR CELL; VIRUS INFECTION;

ANIMALS; BINDING, COMPETITIVE; CELL LINE; ENDOCYTOSIS; ENDOPEPTIDASES; FLOW CYTOMETRY; HSP70 HEAT-SHOCK PROTEINS; HUMANS; JURKAT CELLS; LYMPHOCYTES; MACROPHAGES; MICE; MONOCYTES; PROTEIN BINDING; RECEPTORS, CELL SURFACE;

ANIMALIA; BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 0034500353     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2000.144     Document Type: Article

References (34)

1. Tumor-specific cell surface expression of the-KDEL containing, endoplasmic reticular heat shock protein gp96
2. Receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells
3. Hsp70 stimulates cytokine production through a CD14-dependent pathway, demonstrating its dual role as a chaperone and cytokine
4. Calreticulin, a peptide-binding chaperone of the endoplasmic reticulum, elicits tumor- and peptide-specific immunity
5. CD91: A receptor for heat shock protein gp96
6. Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP
7. Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways
8. The dual nature of specific activity of tumor-derived gp96 preparations
9. Human 60-kDa heat-shock protein: A danger signal to the innate immune system
10. Peptide binding and release by proteins implicated as catalysts of protein assembly
11. Protein folding in the cell
12. Molecular chaperones in cellular protein folding
13. The physiology of transferrin and transferrin receptors
14. Protein folding in vivo: Unraveling complex pathways
15. Heat shock protein (Hsp) 60 activates the innate immune response: CD14 is an essential receptor for Hsp60 activation of mononuclear cells
16. Escherichia coli Dnaj and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK
17. Regulation of the heat-shock protein 70 reaction cycle by the mammalian DnaJ homolog, Hsp40
18. Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70
19. A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells
20. Heat shock protein 72 on tumor cells: A recognition structure for natural killer cells
21. Calreticulin displays in vivo peptide-binding activity and can elicit CTL responses against bound peptides
22. Isolation of an immunodominant viral peptide that is endogenously bound to the stress protein GP96/GRP94
23. Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
24. Interaction of hsp70 with unfolded proteins: Effects of temperature and nucleotides on the kinetics of binding
25. Protein translocation: How Hsp70 pulls it off
26. Heat shock protein-peptide complexes as immunotherapy for human cancer
27. Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries
28. Stress proteins and immunity mediated by cytotoxic T lymphocytes
29. Tumor rejection antigens of chemically induced sarcomas of inbred mice
30. Heat shock proteins come of age: Primitive functions acquire new roles in an adaptive world
31. A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides
32. Heat shock protein 70 induced during tumor cell killing induces Th1 cytokines and targets immature dendritic cell precursors to enhance antigen uptake
33. Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70
34. Receptor mediated and fluid phase pathways for internalization of the ER hsp90 chaperone GRP94 in murine macrophages