Ribose-modified nucleosides as ligands for adenosine receptors: Synthesis, conformational analysis, and biological evaluation of 1′-C-Methyl adenosine analogues

Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2002, Pages 1196-1202

  Cappellacci, Loredana ^a   Barboni, Grazia ^a   Palmieri, Micaela ^a   Pasqualini, Michela ^a   Grifantini, Marlo ^a   Costa, Barbara ^b   Martini, Claudia ^b   Franchetti, Palmarisa ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

6 N CYCLOPENTYLADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A2A RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE DERIVATIVE; ADENYLATE CYCLASE; FORSKOLIN; LIGAND; METHYL GROUP; N (1 METHYL 2 PHENYLETHYL)ADENOSINE; NUCLEOSIDE DERIVATIVE; RIBOSE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CHEMICAL MODIFICATION; CONFORMATIONAL TRANSITION; DRUG ACTIVITY; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; EVALUATION; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ADENOSINE; ADENYLATE CYCLASE; ANIMALS; BINDING, COMPETITIVE; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; NUCLEIC ACID CONFORMATION; RATS; RECEPTORS, PURINERGIC P1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037075782     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0102755     Document Type: Article

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