Hantzsch 1,4-dihydropyridines containing a nitrooxyalkyl ester moiety to study calcium channel antagonist structure-activity relationships and nitric oxide release

Drug Development Research

Volumn 51, Issue 4, 2000, Pages 233-243

  Nguyen, Jeffrey Tri ^a   McEwen, Carol Anne ^a   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

1,4 dihydropyridines; Calcium channel antagonists; Nitric oxide; QSAR

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; DIHYDROPYRIDINE DERIVATIVE; MUSCARINIC RECEPTOR; NIFEDIPINE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DRUG POTENCY; HYDROGEN BOND; MUSCLE CONTRACTION; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REACTION ANALYSIS; SMOOTH MUSCLE;

EID: 0034481244     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.4     Document Type: Article

References (4)

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4. Christiaans JAM, Timmerman H. 1996. Cardiovascular hybrid drugs: combination of more than one pharmacological property in one single molecule. Eur J Pharm Sci 4:1-22.