μ- and δ-opioid receptor mRNAs are expressed in periaqueductal gray neurons projecting to the rostral ventromedial medulla

Neuroscience

Volumn 109, Issue 3, 2002, Pages 619-634

  Wang, H ^b   Wessendorf, M W ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Cell counts; Fluorescent dyes; in situ hybridization; Neural pathways; Opiates; Pain

Indexed keywords

COMPLEMENTARY RNA; DELTA OPIATE RECEPTOR; MESSENGER RNA; MU OPIATE RECEPTOR; OPIATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; BRAIN REGION; CELL LABELING; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; IN SITU HYBRIDIZATION; MALE; MESENCEPHALON; NERVE PROJECTION; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAT;

ANIMALS; CELL COUNT; MALE; MEDULLA OBLONGATA; NEURAL INHIBITION; NEURAL PATHWAYS; NEURONS; NOCICEPTORS; OPIOID PEPTIDES; PAIN; PERIAQUEDUCTAL GRAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; RNA, MESSENGER; SYNAPTIC TRANSMISSION;

EID: 0037074884     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(01)00328-1     Document Type: Article

References (114)

1. Afferent connections of the rostral medulla of the cat: A neural substrate for midbrain-medullary interactions in the modulation of pain
2. Delta (δ)-opioid receptor immunoreactivity: Distribution in brain stem and spinal cord and relationship to biogenic amines and enkephalin
3. Midbrain periaqueductal gray control of defensive behavior in the cat and the rat
4. Columnar organization in the midbrain periaqueductal gray: Modules for emotional expression?
5. Endogenous pain control systems: Brainstem spinal pathways and endorphin circuitry
6. Evidence that an excitatory connection between the periaqueductal gray and nucleus raphe magnus mediates stimulation produced analgesia
7. The effect of GABA and its antagonists on midbrain periaqueductal gray neurons in the rat
8. Response of nucleus raphe magnus neurons to electrical stimulation of nucleus cuneiformis: Role of acetylcholine
9. The nuclei of origin of brain stem enkephalin and substance P projections to the rodent nucleus raphe magnus
10. The sites of origin brain stem neurotensin and serotonin projections to the rodent nucleus raphe magnus
11. Periaqueductal gray
12. The midbrain periaqueductal gray in the rat. II. A Golgi analysis
13. The role of mu and kappa opioid receptors within the periaqueductal gray in the expression of conditional hypoalgesia
14. Evidence for opioid and non-opioid forms of stimulation-produced analgesia in the rat
15. Supramedullary afferents of the nucleus raphe magnus in the rat: A study using the transcannula HRP gel and autoradiographic techniques
16. Molecular cloning and functional expression of a mu-opioid receptor from rat brain
17. Presynaptic location of delta-opioid receptor immunoreactivity in dorsal horn of the rat spinal cord
18. Ultrastructural immunolabeling shows prominent presynaptic vesicular localization of delta-opioid receptor within both enkephalin- and nonenkephalin-containing axon terminals in the superficial layers of the rat cervical spinal cord
19. Hyperpolarization by opioids acting on mu-receptors of a sub-population of rat periaqueductal gray neurones in vitro
20. Inhibition by opioids acting on mu-receptors of GABAergic and glutamatergic postsynaptic potentials in single rat periaqueductal gray neurones in vitro
21. Common patterns of increased and decreased fos expression in midbrain and pons evoked by noxious deep somatic and noxious visceral manipulations in the rat
22. Presynaptic and postsynaptic relations of mu-opioid receptors to gamma-aminobutyric acid-immunoreactive and medullary-projecting periaqueductal gray neurons
23. Anatomical evidence for presynaptic modulation by the delta opioid receptor in the ventrolateral periaqueductal gray of the rat
24. Selectivity of ligands for opioid receptors
25. Evidence that Fluoro-Gold can be transported avidly through fibers of passage
26. Immunofluorescent identification of a delta (delta)-opioid receptor on primary afferent nerve terminals
27. Midbrain and medullary regulation of respiration and vocalization
28. Expression of mu opioid receptor mRNA in rat brain: An in situ hybridization study at the single cell level
29. Quiescence and hyporeactivity evoked by activation of cell bodies in the ventrolateral midbrain periaqueductal gray of the rat
30. Electrophysiology of opioids
31. Cloning of a delta opioid receptor by functional expression
32. The midbrain periaqueductal gray as a coordinator of action in response to fear and anxiety
33. Neurotransmitters in nociceptive modulatory circuits
34. A calbindin immunoreactive 'deep pain' recipient thalamic nucleus in the rat
35. Afferents to brain stem nuclei (brain stem raphe, nucleus reticularis pjontis caudalis and nucleus gigantocellularasis) in the rat as demonstrated by micoiontophoretically applied horseradish peroxidase
36. Involvement of nitric oxide and serotonin in modulation of antinociception and pressor responses evoked by stimulation in the dorsolateral region of the periaqueductal gray matter in the rat
37. Role of nitric oxide and serotonin in modulation of the cardiovascular defence response evoked by stimulation in the periaqueductal grey matter in rats
38. The ventrolateral periaqueductal gray projects to caudal brainstem depressor regions: A functional-anatomical and physiological study
39. Organization of medullary adrenergic and noradrenergic projections to the periaqueductal gray matter in the rat
40. On the central sites for the antinociceptive action of morphine and fentanyl
41. Paradoxical effects after microinjection of morphine in the periaqueductal gray matter in the rat
42. Local connections between the columns of the periaqueductal gray matter: A case for intrinsic neuromodulation
43. Quantitative distribution of the delta opioid receptor mRNA in the mouse and rat CNS
44. Comparison of the antinociceptive action of mu and delta opioid receptor ligands in the periaqueductal gray matter, medial and paramedial ventral medulla in the rat as studied by the microinjection technique
45. Neurochemical study of PAG control of vocal behavior
46. The effects of periaqueductally injected transmitter antagonists on forebrain-elicited vocalization in the squirrel monkey
47. μ-Opioid and δ-opioid receptors are expressed in brainstem antinociceptive circuits: Studies using immunocytochemistry and retrograde tract-tracing
48. Relationship of μ- and δ-opioid receptors to GABAergic neurons in the central nervous system, including antinociceptive brainstem circuits
49. Hyperalgesia during acute opioid abstinence: Evidence for a nociceptive facilitating function of the rostral ventromedial medulla
50. Cardiovascular effects of microinjections of opioid agonists into the 'Depressor Region' of the ventrolateral periaqueductal gray region
51. Spinal afferents to functionally distinct periaqueductal gray columns in the rat: An anterograde and retrograde tracing study
52. The delta-opioid receptor: Isolation of a cDNA by expression cloning and pharmacological characterization
53. Quantitative autoradiographic mapping of mu-, delta- and kappa-opioid receptors in knockout mice lacking the mu-opioid receptor gene
54. Treatment with antisense oligodeoxynucleotide to the opioid delta receptor selectively inhibits delta 2-agonist antinociception
55. Inhibitory effect of nitric oxide on neuronal activity in the periaqueductal grey matter of the rat
56. Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: An in situ hybridization study
57. Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain
58. Connections of midbrain periaqueductal gray in the monkey. II. Descending efferent projections
59. A confocal laser microscopic study of enkephalin-immunoreactive appositions onto physiologically identified neurons in the rostral ventromedial medulla
60. Stimulation-produced analgesia: Development of tolerance and cross-tolerance to morphine
61. Cardiovascular components of the defence reaction evoked by excitation of neuronal cell bodies in the midbrain periaqueductal grey of the cat
62. The distribution of substance P-, enkephalin- and dynorphin-immunoreactive neurons in the medulla of the rat and their contribution to bulbospinal pathways
63. Genomic structure analysis of promoter sequence of a mouse mu opioid receptor gene
64. Immobility and flight associated with antinociception produced by activation of the ventral and lateral/dorsal regions of the rat periaqueductal gray
65. Antagonist-induced opioid receptor up-regulation. II. Regionally specific modulation of mu, delta and kappa binding sites in rat brain revealed by quantitative autoradiography
66. Opioid inhibition of rat periaqueductal grey neurones with identified projections to rostral ventromedial medulla in vitro
67. Characterization of supraspinal antinociceptive actions of opioid delta agonists in the rat
68. Identification and characterization of three new alternatively spliced mu-opioid receptor isoforms
69. Endogenous opioid-mediated inhibition of putative pain-modulating neurons in rat rostral ventromedial medulla
70. Opioid antagonists in the periaqueductal gray inhibit morphine and beta-endorphin analgesia elicited from the amygdala of rats
71. Sites of morphine induced analgesia in the primate brain: Relation to pain pathways
72. Localization of the antinociceptive action of morphine in primate brain
73. Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors
74. Does the PAG learn about emergencies from the superior colliculus?
75. The projection from superior colliculus to cuneiform area in the rat. I. Anatomical studies
76. Contribution of brainstem GABAergic circuitry to descending antinociceptive controls: I. GABA-immunoreactive projection neurons in the periaqueductal gray and nucleus raphe magnus
77. Contribution of brainstem GABAergic circuitry to descending antinociceptive controls: II. Electron microscopic immunocytochemical evidence of GABAergic control over the projection from the periaqueductal gray to the nucleus raphe magnus in the rat
78. Anatomy, physiology and pharmacology of the periaqueductal gray contribution to antinociceptive controls
79. Systemic morphine reduces GABA release in the lateral but not the medial portion of the midbrain periaqueductal gray of the rat
80. Evidence for glutamic acid as a possible neurotransmitter between the mesencephalic nucleus cuneiformis and the medullary nucleus raphe magnus in the lightly anesthetized rat
81. The delta2-opioid receptor subtype stimulates phosphoinositide metabolism in mouse periaqueductal gray matter
82. Mu and delta opioid synergy between the periaqueductal gray and the rostro-ventral medulla
83. Endogenous opioids acting at a medullary mu-opioid receptor contribute to the behavioral antinociception produced by GABA antagonism in the midbrain periaqueductal gray
84. Fluoro-Gold: A new fluorescent retrograde axonal tracer with numerous unique properties
85. Immunolocalization of two mu-opioid receptor isoforms (Mor1 and Mor1b) in the rat central nervous system
86. Discrete mapping of brain Mu and delta opioid receptors using selective peptides: Quantitative autoradiography, species differences and comparison with kappa receptors
87. Analgesia and hyperreactivity produced by intracranial microinjections of morphine into the periaqueductal gray matter of the rat
88. The unbiased estimation of number and sizes of arbitrary particles using the disector
89. Ultrastructural localization of delta-opioid receptor and Met5-enkephalin immunoreactivity in rat insular cortex
90. Cellular sites for activation of delta-opioid receptors in the rat nucleus accumbens shell: Relationship with Met5-enkephalin
91. Methodological considerations in the utilization of in situ hybridization
92. Neuroanatomical patterns of the mu, delta, and kappa opioid receptors of rat brain as determined by quantitative in vitro autoradiography
93. Cloning and pharmacological characterization of a rat mu opioid receptor
94. Probes
95. Nuclei within the rostral ventromedial medulla mediating morphine antinociception from the periaqueductal gray
96. Presynaptic inhibitory action of opioids on synaptic transmission in the rat periaqueductal grey in vitro
97. How opioids inhibit GABA-mediated neurotransmission
98. μ- and δ-opioid receptor mRNAs are expressed in spinally projecting serotonergic and nonserotonergic neurons of the rostral ventromedial medulla
99. Equal proportions of small and large DRG neurons express opioid receptor mRNAs
100. Antisense oligodeoxynucleotide to a delta-opioid receptor messenger RNA selectively blocks the antinociception induced by intracerebroventricularly administered delta-, but not mu-, epsilon- or kappa-opioid receptor agonists in the mouse
101. Fluoro-Gold: Composition, and mechanism of uptake
102. Basal release of Met-enkephalin and neurotensin in the ventrolateral periaqueductal gray matter of the rat: A microdialysis study of antinociceptive circuits
103. Factors governing release of methionine enkephalin-like immunoreactivity from mesencephalon and spinal cord of the cat in vivo
104. Narcotic analgestics: CNS sites and mechanisms of action as revealed by intracerebral injection techniques
105. Microinjection of morphine into the periaqueductal gray evokes the release of serotonin from spinal cord
106. Systematic examination in the rat of brain sites sensitive to the direct application of morphine: Observation of differential effects within the periaqueductal gray
107. Cloning, characterization, and distribution of a mu-opioid receptor in rat brain
108. Nucleus cuneiformis and pain modulation: Anatomy and behavioral pharmacology
109. Brain stem integration of vocalization: Role of the midbrain periaqueductal gray
110. Localization and regulation of the delta-opioid receptor in dorsal root ganglia and spinal cord of the rat and monkey: Evidence for association with the membrane of large dense-core vesicles
111. Spinal serotonin receptors mediate descending facilitation of a nociceptive reflex from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat
112. Characterization of descending facilitation and inhibition of spinal nociceptive transmission from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat
113. Biphasic modulation of spinal nociceptive transmission from the medullary raphe nuclei in the rat