Involvement of nitric oxide and serotonin in modulation of antinociception and pressor responses evoked by stimulation in the dorsolateral region of the periaqueductal gray matter in the rat

Neuroscience

Volumn 80, Issue 3, 1997, Pages 821-827

  Hamalainen M M ^a   Lovick, T A ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

5 HT; Antinociception; Blood pressure; Nitric oxide; Periaqueductal gray matter

Indexed keywords

SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; EVOKED RESPONSE; HEART OUTPUT; IMMUNOREACTIVITY; NOCICEPTIVE STIMULATION; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; STIMULUS RESPONSE; TAIL FLICK TEST;

ANIMALS; BLOOD PRESSURE; BRAIN MAPPING; ELECTRIC STIMULATION; HEAT; INTERNEURONS; MALE; MICROINJECTIONS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; PAIN; PERIAQUEDUCTAL GRAY; RATS; RATS, WISTAR; REACTION TIME; SEROTONIN; STEREOISOMERISM;

EID: 0343196664     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(97)00124-3     Document Type: Article

References (28)

1. Bandler R. and Shipley M. T. (1994) Columnar organization in the midbrain periaqueductal gray: modules for emotional expression? Trends Neurosci. 17, 379-389.
2. 1 receptor agonists administered into the periaqueductal grey. Psychopharmacology 108, 110-114.
3. Behebehani M. M. (1995) Functional characteristics of the midbrain periaqueductal gray. Prog. Neurobiol. 46, 575-605.
4. Behbehani M. M., Liu H., Jiang M., Pun R. Y. K. and Shipley M. T. (1993) Activation of serotonin 1A receptors inhibits midbrain periaqueductal gray neurons in the rat. Brain Res. 612, 56-60.
5. Beitz A., Clements J. R., Mullett M. and Ecklund L. (1986) Differential origin of brainstem serotonergic projections to the midbrain periaqueductal gray and superior colliculus of the rat. J. comp. Neurol. 250, 498-509.
6. Clements J. R., Beitz A. J., Fletcher T. F. and Mullett M. A. (1985) Immunocytochemical localization of serotonin in the rat periaqueductal gray: a quantitative light and electron microscopic study. J. comp. Neurol. 236, 60-70.
7. D'Amico M., Berrino L., Filipelli A., Maione S. and Rossi F. (1994) Relation between L-arginine-nitric oxide pathway and endothelin-1 effects in periaqueductal gray area of rats. J. cardiovasc. Pharmac. 24, 974-978.
8. Duggan A. W. and Morton C. R. (1983) Periaqueductal grey stimulation: an association between selective inhibition of dorsal horn neurones and changes in peripheral circulation. Pain 15, 237-248.
9. Gonzales-Hernandez T., Condescendin M. and Mayer G. (1992) Laminar distribution and morphology of NADPH-diaphorase containing neurons in the superior colliculus and underlying periaqueductal grey of the rat. Anat. Embryol. 186, 245-250.
10. Graeff F. G., Brandao M. L., Audi E. A. and Schutz M. T. (1986) Modulation of brain aversive system by GABAergic and serotonergic mechanisms. Behav. Brain Res. 21, 65-72.
11. 3 receptors. Psychopharmacology 97, 489-495.
12. Kiser R., German D. C. and Lebowitz R. M. (1978) Serotonergic reduction of dorsal central gray stimulation-produced aversion. Pharmac. Biochem. Behav. 9, 27-32.
13. Lorrain D. S. and Hull E. M. (1993) Nitric oxide increases dopamine and serotonin release in the medial preoptic area. NeuroReport 5, 87-89.
14. Lovick T. A. (1985) Ventrolateral medullary lesions block the the antinociceptive and cardiovascular responses elicited by stimulating in the dorsal periaqueductal grey matter in rats. Pain 21, 241-252.
15. Lovick T. A. (1993) Integrated activity of cardiovascular and pain regulatory systems: role in adaptive behavioural responses. Prog. Neurobiol. 40, 631-644.
16. Lovick T. A. (1993) Serotonergic influence from nucleus raphe obscurus on neurones in the periaqueductal grey matter in the rat. Brain Res. 606, 92-98.
17. Lovick T. A. (1996) Role of nitric oxide in medullary raphe-evoked inhibition of neuronal activity in the periaqueductal grey matter. Neuroscience 75, 1203-1209.
18. Lovick T. A. and Key B. J. (1996) Inhibitory effect of nitric oxide on neuronal activity in the periaqueductal grey matter of the rat. Expl Brain Res. 108, 382-388.
19. Nogueira R. L. and Graeff F. G. (1995) Role of 5-HT receptors in the modulation of dorsal periaqueductal gray generated aversion. Pharmac. Biochem. Behav. 52, 1-6.
20. Onstott D., Mayer R. B. and Beitz A. J. (1993) Nitric oxide synthase immunoreactive neurons anatomically define a longitudinal dorsolateral column within the midbrain periaqueductal grey of the rat - analysis using laser confocal microscopy. Brain Res. 610, 317-324.
21. Paxinos G. and Watson C. (1986) A Stereotaxic Atlas of the Rat Brain. 2nd edn. Academic, New York.
22. Pogun S. and Kuhar M. J. (1994) Regulation of neurotransmitter reuptake by nitric oxide. Ann. N.Y. Acad. Sci. 734, 305-315.
23. Salter M., Duffy C., Garthwaite J. and Strijbos P. J. L. M. (1995) Substantial regional and hemispheric differences in brain nitric oxide synthase (NOS) inhibition following intracerebroventricular administration of N-nitro-L-arginine (L-NA) and its methyl ester (L-NAME). Neuropharmacology 34, 639-649.
24. Schmitt P., Eclancher E. and Karli P. (1974) Etude des systèmes de renforcement negatif et de renforcement positif au niveau de la substance grise centrale chez le rat. Physiol. Behav. 12, 271-279.
25. Schmitt P., Sandner G., Colpaert F. C. and DeWitte P. (1983) Effects of dorsal raphe stimulation on escape induced by medial hypothalamic or central gray stimulation. Behav. Brain Res. 8, 298-307.
26. Shutz M. T. B., DeAguiar J. C. and Graeff F. G. (1985) Antiaversive role of serotonin in the dorsal PAG. Psychopharmacology 85, 340-345.
27. Vincent S. R. and Kimura H. (1992) Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience 46, 111-121.
28. Walker J. M. and Dixon W. C. (1983) A solid state device for measuring sensitivity to thermal pain. Physiol. Behav. 30, 481-483.