Lipases and (R)-oxynitrilases: Useful tools in organic synthesis

Journal of Biotechnology

Volumn 96, Issue 1, 2002, Pages 35-42

  Gotor, Vicente ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

Author keywords

Amines; Azamacrocycles; Cyanohydrins; Lipases; Nucleosides; Oxynitrilases

Indexed keywords

AMINES; ESTERS; ORGANIC SOLVENTS; SYNTHESIS (CHEMICAL);

CHEMOSELECTIVE REACTIONS;

ENZYMES;

AMIDE; AMINE; ANTISENSE OLIGONUCLEOTIDE; CYANOHYDRIN; ESTER DERIVATIVE; LIPASE B; LYASE; ORGANIC SOLVENT; OXYNITRILASE; PYRROLIDINE DERIVATIVE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ACYLATION; ASYMMETRIC CATALYSIS; BIOCATALYST; CHEMICAL REACTION; CONFERENCE PAPER; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY; TRANSESTERIFICATION;

ALDEHYDE-LYASES; CHEMISTRY, ORGANIC; LIPASE; NITRILES; NUCLEOSIDES; STEREOISOMERISM;

EID: 0037071912     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(02)00035-4     Document Type: Conference Paper

References (37)

1. Sequential biocatalytic resolution of (±)-trans-cyclohexane-1,2-diamine. Chemoenzymatic synthesis of an optically active polyamine
2. Optically active tetraazamacrocycles analogous to cyclam
3. Chemoenzymatic synthesis of two optically active hexaazamacrocycles
4. Optically active dioxatetraazamacrocycles: Chemoenzymatic synthesis and applications in chiral anion recognition
5. Biocatalysis in the enantioselective formation of chiral cyanohydrins, valuable building blocks in organic synthesis
6. Properties and synthetic applications of enzymes in organic solvents
7. Enzymatic desymmetrization of meso cis-2,6- and cis,cis-2,4,6-substituted piperidines. Chemoenzymatic synthesis of (5S,9S)-(±) indolizine 209D
8. Synthesis and reactions of optically active cyanohydrins
9. Hydroxynitrile lyases in stereoselective synthesis
10. Synthesis of the adrenergic bronchodilators (R)-terbutaline and (R)-salbutamol from (R)-cyanohydrins
11. Chemoenzymatic transformations in nucleoside chemistry
12. Biocatalytic selective modifications of conventional nucleosides, carbocyclic nucleosides, and C-nucleosides
13. Chemoenzymatic aminolysis and ammonolysis of β-ketoesters
14. Synthesis of 5′ and 3′-O-nucleoside carbamates
15. Chemoenzymatic synthesis of 2′-deoxynucleoside urethanes
16. Enzymatic ammonolysis of ethyl (±)-4-chloro-3-hydroxybutanoate. Chemoenzymatic syntheses of both enantiomers of pyrrolidin-3-ol and 5-(chloromethyl)-1,3-oxazolidin-2-one
17. Enzymatic one-pot resolution of two nucleophiles: Alcohol and amine
18. Non-conventional hydrolase chemistry: Amide and carbamate bond formation catalysed by lipases
19. Enzymatic aminolysis and ammonolysis reactions
20. A simple procedure for the preparation of chiral amides
21. Cyanohydrins in nature and in the laboratory: Biology, preparations and synthetic applications
22. The synthesis of chiral cyanohydrins by oxynitrilases
23. Novel (R)-oxynitrilase sources for the synthesis of (R)-cyanohydrins in diisopropyl ether
24. Enzymes for chemical synthesis
25. Chemoenzymatic synthesis of novel 3′- and 5′-carbazoyl nucleoside derivatives. Regioselective preparation of 3′- and 5′-alkylidencarbazoyl nucleosides
26. Synthesis of novel carbazoyl linked pyrimidine-pyrimidine and pyrimidine-purine dinucleotide analogues
27. Optically active (S)-ketone- and (R)-aldehyde-cyanohydrins via an (R)-oxynitrilase-catalysed transcyanation. Chemoenzymatic synthesis of 2-cyanotetrahydrofuran and 2-cyanotetrahydropyran
28. Lipase-mediated alkoxycarbonylation of nucleosides with oxime carbonates
29. A novel and convenient route to 3′carbonates from unprotected 2′-deoxynucleosides through an enzymatic reaction
30. Chemoenzymatic synthesis of azacycloalkan-3-ols
31. Chemoenzymatic synthesis of (S)-2-cyanopyperidine, a key intermediate in the route to (S)-pipecolic acid and 2-substituted piperidine alkaloids
32. Enzymatic aminolysis and ammonolysis of dimethyl 3-hydroxyglutarate. Synthesis of (R)-4-Amino-3-hydroxybutanoic acid
33. Nitrogen analogous of crow ethers
34. Candida antarctica lipase catalysed doubly enantioselective aminolysis reactions. Chemoenzymatic synthesis of 3-hydroxypyrrolidines and 4-(silyloxy)-2-oxopyrrolidines with two stereogenic centres
35. Lipase catalyzed synthesis of carboxylic amides: Nitrogen nucleophiles as acyl donors