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Volumn 45, Issue 19, 2002, Pages 4094-4096

Pyrimidinylpyrroloquinolones as highly potent and selective PDE5 inhibitors for treatment of erectile dysfunction

(11) Sui, Zhihua a Guan, Jihua a Macielag, Mark J a Jiang, Weiqin a Zhang, Suying a Qiu, Yuhong a Kraft, Patricia a Bhattacharjee, Sheela a John, T Matthew a Haynes Johnson, Donna a Clancy, Joanna a

a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP; PHOSPHODIESTERASE; PHOSPHODIESTERASE I; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE V; PYRIMIDINYLPYRROLOQUINOLONE DERIVATIVE; QUINOLONE DERIVATIVE; SILDENAFIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; ERECTILE DYSFUNCTION; MALE; NONHUMAN; PENIS ERECTION; RAT; STRUCTURE ACTIVITY RELATION;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; DOGS; ENZYME INHIBITORS; IMPOTENCE; MALE; QUINOLONES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037068429 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm025545d Document Type: Article

Times cited : (23)

References (20)

1
- 0028802726
- Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
- (1995) Physiol. Rev. , vol.75 , pp. 725-748
- Beavo, J.A.¹

2
- 0034009080
- Regulation of cAMP and cGMP signaling: New phosphodiesterases and new functions
- (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 174-179
- Soderling, S.H.¹ Beavo, J.A.²

3
- 0034724177
- Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A
- (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 3702-3707
- Fawcett, L.¹ Baxendale, R.² Stacey, P.³ McGrouther, C.⁴

4
- 0030154874
- Sildenalfil: An orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction
- (1996) Int. J. Impotence Res. , vol.8 , pp. 47-52
- Boolell, M.¹ Allen, M.J.² Ballard, S.A.³ Gepi-Attee, S.⁴ Muirhead, G.J.⁵

5
- 0033553509
- Cyclic GMP phosphodiesterases-5: Target of sildenafil
- and references therein
- (1999) J. Biol. Chem. , vol.274 , pp. 13729-13732
- Corbin, J.¹ Francis, S.²

6
- 0029994170
- Phosphodiesterase 5 inhibitors in development for cardiovascular therapy
- (1996) Exp. Opin. Invest. Drugs , vol.5 , pp. 1477-1486
- Saeki, T.¹ Takase, Y.²

7
- 0035966869
- Substituted pyrazolopyridines as potent and selective PDE5 inhibitors: Potential agents for treatment of erectile dysfunction
- (2001) J. Med. Chem. , vol.44 , pp. 1025-1027
- Yu, G.¹ Mason, H.J.² Wu, X.³ Wang, J.⁴ Chong, S.⁵ Dorough, G.⁶ Henwood, A.⁷ Pongrac, R.⁸ Seliger, L.⁹ He, B.¹⁰ Normandin, D.¹¹ Adam, L.¹² Krupinskin, J.¹³ Macor, J.¹⁴

8
- 0034611619
- N-3-substituted imidazoquinazolinones: Potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction
- (2000) J. Med. Chem. , vol.434 , pp. 1257-1263
- Rotella, D.P.¹ Sun, Z.² Zhu, Y.³ Krupinskin, J.⁴ Pongrac, R.⁵ Seliger, L.⁶ Normandin, D.⁷ Adam, L.⁸ Macor, J.⁹

9
- 0035927445
- Novel, potent, and selective phosphodiesterase 5 inhibitors: Synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives
- (2001) J. Med. Chem. , vol.44 , pp. 2204-2218
- Ukita, T.¹ Nakamura, Y.² Kubo, A.³ Yamamoto, Y.⁴ Moritani, Y.⁵ Saruta, K.⁶ Higashijima, T.⁷ Kotera, J.⁸ Takagi, M.⁹ Kikkawa, K.¹⁰ Omori, K.¹¹

10
- 0034933112
- Synthesis and phosphodiesterase 5 inhibitory activity of new 5-phenyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one derivatives containing an N-acylamido group on a phenyl ring
- (2001) Bioorg. Med. Chem. , vol.9 , pp. 1895-1899
- Kim, D.-K.¹ Ryu, D.H.² Lee, N.³ Lee, J.Y.⁴ Kim, J.-S.⁵ Lee, S.⁶ Choi, J.-Y.⁷ Ryu, J.-H.⁸ Kim, N.-H.⁹ Im, G.-J.¹⁰ Choi, W.-S.¹¹ Kim, T.-K.¹²

11
- 0034812246
- Synthesis and phosphodiesterase inhibitory activity of new sildenafil analogues containing a carboxylic acid group in the 5′-sulfonamide moiety of a phenyl ring
- (2001) Bioorg. Med. Chem. , vol.9 , pp. 3013-3021
- Kim, D.-K.¹ Lee, J.Y.² Lee, N.³ Ryu, D.H.⁴ Kim, J.-S.⁵ Lee, S.⁶ Choi, J.-Y.⁷ Ryu, J.-H.⁸ Kim, N.-H.⁹ Im, G.-J.¹⁰ Choi, W.-S.¹¹ Kim, T.-K.¹²

12
- 0005283263
- Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors. PCT Appl. WO 0187882, 2001
- Sui, Z.¹ Macielag, M.J.² Guan, J.³ Jiang, W.⁴ Lanter, J.⁵

13
- 0005364310
- Preparation of β-carboline derivatives useful as inhibitors of phosphodiesterase PCT Appl. WO 0187038, 2001
- Sui, Z.¹ Macielag, M.J.²

14
- 0005338666
- Preparation of 5-heterocyclyl pyrazolo [4,3-d]pyrimidin-7-ones for the treatment of male erectile dysfunction. U.S. Patent 6,077,841, 2000
- Sui, Z.¹ Macielag, M.J.² Guan, J.³

15
- 0037294043
- Synthesis and biological activities of N-furoyl β-carbolines as PDE5 inhibitors
- submitted for publication
- Bioorg. Med. Chem. Lett.
- Sui, Z.¹ Guan, J.² Macielag, M.J.³ Jiang, W.⁴ Qiu, Y.⁵ Kraft, P.⁶ Bhattacharjee, S.⁷ Craig, E.⁸ Haynes-Johnson, D.⁹ Clancy, J.¹⁰

16
- 0005387733
- Discovery of pyrimidinyl β-carbolines as potent PDE5 inhibitors
- submitted for publication
- Bioorg. Med. Chem. Lett.
- Sui, Z.¹ Guan, J.² Jiang, W.³ Macielag, M.J.⁴ Qiu, Y.⁵ Bhattacharjee, S.⁶ Haynes-Johnson, D.⁷ John, T.M.⁸ Craig, E.⁹ Kraft, P.¹⁰ Clancy, J.¹¹

17
- 0002644361
- Chinolon-derivate duerch autoxydation
- (1971) Liebigs Ann. Chem. , vol.745 , pp. 23-30
- Winterfeld, E.¹

18
- 0015268365
- Die autoxydative indol-chinolon-umwandlung eines camptothecin-models
- (1972) Chem. Ber. , vol.105 , pp. 2120-2125
- Warneke, J.¹ Winterfeldt, E.²

19
- 0015269316
- Die biogenetisch orientierte totalsynthese von DL-Camptothecin und 7-chlor-camptothecin
- (1972) Chem. Ber. , vol.105 , pp. 2126-2142
- Boch, M.¹ Korth, T.² Nelke, J.M.³ Pike, D.⁴ Radunz, H.⁵ Winterfeldt, E.⁶

20
- 0005277622
- Preparation of antihypertensive carboline derivatives. PCT Appl. WO 97/43287, 1997
- Bombrun, A.¹

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