Hypoxia and HIF-1α stability: Another stress-sensing mechanism for Shc

Circulation Research

Volumn 91, Issue 1, 2002, Pages 4-6

  Abe, Jun ichi ^a   Berk, Bradford C ^a  

^a Cardiology Unit   (United States)

Author keywords

Hypoxia; Hypoxia inducible factor 1; Shc; Signal transduction

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBRONECTIN; G PROTEIN COUPLED RECEPTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 1; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN P21; PROTEIN P53; PROTEIN P66; PROTEIN SHC; RAF PROTEIN; RAS PROTEIN; SOS PROTEIN; DNA BINDING PROTEIN; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1; NUCLEAR PROTEIN; PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SRC HOMOLOGY 2 DOMAIN CONTAINING, TRANSFORMING PROTEIN 1; SRC HOMOLOGY 2 DOMAIN-CONTAINING, TRANSFORMING PROTEIN 1; TRANSCRIPTION FACTOR; UBIQUITIN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

CELL MIGRATION; EDITORIAL; ENZYME ACTIVITY; HYPOXIA; MOLECULAR WEIGHT; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRESS; CELL HYPOXIA; CYTOLOGY; HUMAN; METABOLISM; NOTE; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; CELL HYPOXIA; DNA-BINDING PROTEINS; ENDOTHELIUM, VASCULAR; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NUCLEAR PROTEINS; PROTEINS; SIGNAL TRANSDUCTION; STRESS; TRANSCRIPTION FACTORS; UBIQUITIN;

EID: 0037067313     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000026654.65882.55     Document Type: Editorial

References (23)

1. 2 homeostasis by hypoxia-inducible factor 1
2. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
3. 2 homeostasis by hypoxia-inducible factor 1α
4. Hypoxic induction of the hypoxia-inducible factor is mediated via the adaptor protein Shc in endothelial cells
5. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
6. Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation
7. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
8. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
9. p42/p44 mitogen activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
10. Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TALI/SCL transcription factor in endothelial cells
11. The p66shc adaptor protein controls oxidative stress response and life span in mammals
12. Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
13. Stabilization of wild-type p53 by hypoxia-inducible factor 1α
14. Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway
15. The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway
16. The src homology 2 and phosphotyrosine binding domains of the ShcC adaptor protein function as inhibitors of mitogenic signaling by the epidermal growth factor receptor
17. Hydrogen peroxide induces complex formation of SHC- Grb2-SOS with receptor tyrosine kinase and activates Ras and extracellular signal-regulated protein kinases group of mitogen-activated protein kinases
18. G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts: Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases
19. Shc proteins are localized on endoplasmatic reticulum membranes and are redistributed after tyrosine kinase receptor activation
20. Angiotensin II induces transactivation of two different populations of the PDGFβ-receptor: Key role for the adaptor protein Shc
21. Shc and FAK differentially regulate cell motility and directionality modulated by PTEN
22. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage dependent cell growth
23. Functional importance of Shc tyrosine 317 on insulin signaling in Rat1 fibroblasts expressing insulin receptors