Lysergic acid diethylamide-induced Fos expression in rat brain: Role of serotonin-2A receptors

Neuroscience

Volumn 114, Issue 3, 2002, Pages 707-713

  Gresch, P J ^a   Strickland, L V ^a   Sanders Bush, E ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amygdala; Anterior cingulate cortex; DOI; Hallucinogen; LSD; Medial prefrontal cortex

Indexed keywords

ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; LYSERGIDE; PROTEIN FOS; SEROTONIN 2A RECEPTOR; SEROTONIN ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN DEPTH STIMULATION; BRAIN REGION; BRAIN TISSUE; CELL ACTIVATION; CONTROLLED STUDY; HALLUCINATION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; TIME;

ANIMALS; BRAIN; GENE EXPRESSION REGULATION; HALLUCINOGENS; LYSERGIC ACID DIETHYLAMIDE; MALE; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN;

EID: 0037063688     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(02)00349-4     Document Type: Article

References (24)

1. Abi-Saab W.M., Bubser M., Roth R.H., Deutch A.Y. 5-HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex. Neuropsychopharmacology. 20:1999;92-96.
2. Aghajanian G.K., Marek G.J. Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells. Neuropharmacology. 36:1997;589-599.
3. Aghajanian G.K., Marek G.J. Serotonin and hallucinogens. Neuropsychopharmacology. 21:1999;16S-23S.
4. Aghajanian G.K., Marek G.J. Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release. Brain Res. 825:1999;161-171.
5. Chaudhuri A. Neural activity mapping with inducible transcription factors. NeuroReport. 8:1997;iii-vii.
6. Cornea-Hebert V., Riad M., Wu C., Singh S.K., Descarries L. Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult rat. J. Comp. Neurol. 409:1999;187-209.
7. Erdtmann-Vourliotis M., Mayer P., Riechert U., Hollt V. Acute injection of drugs with low addictive potential (delta(9)-tetrahydrocannabinol, 3,4-methylenedioxymethamphetamine, lysergic acid diamide) causes a much higher c-fos expression in limbic brain areas than highly addicting drugs (cocaine and morphine). Brain Res. Mol. Brain Res. 71:1999;313-324.
8. 2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology (Berl.). 121:1995;347-356.
9. Jakab R.L., Goldman-Rakic P.S. 5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites. Proc. Natl. Acad. Sci. USA. 95:1998;735-740.
10. 2C receptors. Neuropsychopharmacology. 18:1998;339-351.
11. Leslie R.A., Moorman J.M., Coulson A., Grahame-Smith D.G. Serotonin2/1C receptor activation causes a localized expression of the immediate-early gene c-fos in rat brain: evidence for involvement of dorsal raphe nucleus projection fibres. Neuroscience. 53:1993;457-463.
12. Mackowiak M., Chocyk A., Fijal K., Czyrak A., Wedzony K. c-Fos proteins, induced by the serotonin receptor agonist DOI, are not expressed in 5-HT2A positive cortical neurons. Brain Res. Mol. Brain Res. 71:1999;358-363.
13. Marek G.J., Wright R.A., Gewirtz J.C., Schoepp D.D. A major role for thalamocortical afferents in serotonergic hallucinogen receptor function in the rat neocortex. Neuroscience. 105:2001;379-392.
14. Marek G.J., Wright R.A., Schoepp D.D., Monn J.A., Aghajanian G.K. Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex. J. Pharmacol. Exp. Ther. 292:2000;76-87.
15. Moorman J.M., Leslie R.A. P-chloroamphetamine induces c-fos in rat brain: a study of serotonin2A/2C receptor function. Neuroscience. 72:1996;129-139.
16. Parker L.A. LSD produces place preference and flavor avoidance but does not produce flavor aversion in rats. Behav. Neurosci. 110:1996;503-508.
17. Paxinos, G., Watson, C., 1986. The Rat Brain in Stereotaxic Coordinates. Academic Press, New York.
18. 2A heteroreceptors on thalamocortical glutamatergic neurons. J. Neurosci. 20:2000;8846-8852.
19. Sorensen S.M., Kehne J.H., Fadayel G.M., Humphreys T.M., Ketteler H.J., Sullivan C.K., Taylor V.L., Schmidt C.J. Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J. Pharmacol. Exp. Ther. 266:1993;684-691.
20. Tilakaratne N., Friedman E. Genomic responses to 5-HT1A or 5-HT2A/2C receptor activation is differentially regulated in four regions of rat brain. Eur. J. Pharmacol. 307:1996;211-217.
21. Van de Kar L.D., Javed A., Zhang Y., Serres F., Raap D.K., Gray T.S. 5-HT2A receptors stimulate ACTH, corticosterone, oxytocin, renin, and prolactin release and activate hypothalamic CRF and oxytocin-expressing cells. J. Neurosci. 21:2001;3572-3579.
22. Vollenweider F.X., Leenders K.L., Scharfetter C., Maguire P., Stadelmann O., Angst J. Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis. Neuropsychopharmacology. 16:1997;357-372.
23. Vollenweider F.X., Vollenweider-Scherpenhuyzen M.F., Babler A., Vogel H., Hell D. Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action. NeuroReport. 9:1998;3897-3902.
24. Willins D.L., Deutch A.Y., Roth B.L. Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex. Synapse. 27:1997;79-82.