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Volumn 54, Issue 4, 1997, Pages 459-465

Histidine to alanine mutants of human dihydroorotate dehydrogenase: Identification of a brequinar-resistant mutant enzyme

Author keywords

Anti proliferative; Brequinar; Dihydroorotate dehydrogenase; Immunosuppression; Mutagenesis; Pyrimidine biosynthesis

Indexed keywords

ALANINE; BREQUINAR; DIHYDROOROTATE DEHYDROGENASE; HISTIDINE;

EID: 0030986397     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00197-4     Document Type: Article
Times cited : (22)

References (20)
  • 2
    • 0027786829 scopus 로고
    • The development of brequinar as an immunosuppressive drug for transplantation
    • Makowka L, Sher LS and Cramer DV, The development of brequinar as an immunosuppressive drug for transplantation, Immunol Rev 136: 51-70, 1993.
    • (1993) Immunol Rev , vol.136 , pp. 51-70
    • Makowka, L.1    Sher, L.S.2    Cramer, D.V.3
  • 4
    • 0028354267 scopus 로고
    • Leflunomide in experimental transplantation. Control of rejection and alloantibody production, reversal of acute rejection, and interaction with cyclosporin
    • Williams JW, Xiao F, Foster P, Clardy C, McChesney L, Sankary H and Chong AS-F, Leflunomide in experimental transplantation. Control of rejection and alloantibody production, reversal of acute rejection, and interaction with cyclosporin. Transplantation 57: 1223-1231, 1994.
    • (1994) Transplantation , vol.57 , pp. 1223-1231
    • Williams, J.W.1    Xiao, F.2    Foster, P.3    Clardy, C.4    McChesney, L.5    Sankary, H.6    As-F, C.7
  • 6
    • 0026690437 scopus 로고
    • Inhibition of dihydroorotate dehydrogenase activity by brequinar sodium
    • Chen SF, Perrella FW, Behrens DL and Papp LM, Inhibition of dihydroorotate dehydrogenase activity by brequinar sodium. Cancer Res 52: 3521-3527, 1992.
    • (1992) Cancer Res , vol.52 , pp. 3521-3527
    • Chen, S.F.1    Perrella, F.W.2    Behrens, D.L.3    Papp, L.M.4
  • 7
    • 0030032806 scopus 로고    scopus 로고
    • The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase
    • Davis JP, Cain GA, Pitts WJ, Magolda RL and Copeland RA, The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry 35: 1270-1273, 1996.
    • (1996) Biochemistry , vol.35 , pp. 1270-1273
    • Davis, J.P.1    Cain, G.A.2    Pitts, W.J.3    Magolda, R.L.4    Copeland, R.A.5
  • 9
    • 0029050136 scopus 로고
    • Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide
    • Greene S, Watanabe K, Braatz-Trulson J and Lou L, Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide. Biochem Pharmacol 50: 861-867, 1995.
    • (1995) Biochem Pharmacol , vol.50 , pp. 861-867
    • Greene, S.1    Watanabe, K.2    Braatz-Trulson, J.3    Lou, L.4
  • 10
    • 0028820543 scopus 로고
    • Recombinant human dihydroorotate dehydrogenase: Expression, purification and characterization of a catalytically functional truncated enzyme
    • Copeland RA, Davis JP, Dowling RL, Lomoardo D, Murphy KB and Patterson TA, Recombinant human dihydroorotate dehydrogenase: Expression, purification and characterization of a catalytically functional truncated enzyme. Arch Biochem Biophys 323: 79-86, 1995.
    • (1995) Arch Biochem Biophys , vol.323 , pp. 79-86
    • Copeland, R.A.1    Davis, J.P.2    Dowling, R.L.3    Lomoardo, D.4    Murphy, K.B.5    Patterson, T.A.6
  • 11
    • 0026492454 scopus 로고
    • Cloning and sequencing of a human cDNA coding for dihydroorotate dehydrogenase by complementation of the corresponding yeast mutant
    • Minet M, Dufour M-E and Lacroute F, Cloning and sequencing of a human cDNA coding for dihydroorotate dehydrogenase by complementation of the corresponding yeast mutant. Gene 121: 393-396, 1992.
    • (1992) Gene , vol.121 , pp. 393-396
    • Minet, M.1    Dufour, M.-E.2    Lacroute, F.3
  • 13
    • 0017832712 scopus 로고
    • Dihydroorotate dehydrogenase (Neurospora)
    • Miller RW, Dihydroorotate dehydrogenase (Neurospora). Methods Enzymol 51: 63-69, 1978.
    • (1978) Methods Enzymol , vol.51 , pp. 63-69
    • Miller, R.W.1
  • 14
    • 0001169698 scopus 로고
    • Some kinetic consequences of the tight binding of protein-proteinase-inhibitors to proteolytic enzymes and their application to the determination of dissociation constants
    • Springer, New York
    • Bieth J, Some kinetic consequences of the tight binding of protein-proteinase-inhibitors to proteolytic enzymes and their application to the determination of dissociation constants. In: Proteinase Inhibitors, Bayer-Symposium V, pp. 463-469. Springer, New York, 1974.
    • (1974) Proteinase Inhibitors, Bayer-Symposium , vol.5 , pp. 463-469
    • Bieth, J.1
  • 15
    • 0018699952 scopus 로고
    • The kinetics of reversible tight-binding inhibition
    • Williams JW and Morrison JF, The kinetics of reversible tight-binding inhibition. Methods Enzymol 63: 437-467, 1979.
    • (1979) Methods Enzymol , vol.63 , pp. 437-467
    • Williams, J.W.1    Morrison, J.F.2
  • 17
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 18
    • 0014454095 scopus 로고
    • Kinetics of the reversible inhibition of enzyme-catalyzed reactions by tight-binding inhibitors
    • Morrison JF, Kinetics of the reversible inhibition of enzyme-catalyzed reactions by tight-binding inhibitors. Biochim Biophys Acta 185: 269-286, 1969.
    • (1969) Biochim Biophys Acta , vol.185 , pp. 269-286
    • Morrison, J.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.