Spinal lamina I neurones that express neurokinin 1 receptors: II. Electrophysiological characteristics, responses to primary afferent stimulation and effects of a selective μ-opioid receptor agonist

Neuroscience

Volumn 111, Issue 2, 2002, Pages 423-434

  Cheunsuang, O ^a,b   Maxwell, D ^c   Morris, R ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b CHULALONGKORN UNIVERSITY   (Thailand)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Lamina I; Neurokinin 1; Nociception; Pain; Spinal cord; Substance P

Indexed keywords

ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MU OPIATE RECEPTOR AGONIST; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; SUBSTANCE P DERIVATIVE;

ANALGESIA; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; DENDRITE; DEPOLARIZATION; DRUG EFFECT; DRUG SENSITIVITY; ELECTROPHYSIOLOGY; IMMUNOCYTOCHEMISTRY; INTERNEURON; INTRACELLULAR RECORDING; NERVE FIBER C; NERVE STIMULATION; NEUROCHEMISTRY; NEWBORN; NOCICEPTION; NONHUMAN; PAIN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORY STIMULATION; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; SUBSTANTIA GELATINOSA;

ACTION POTENTIALS; AFFERENT PATHWAYS; ANIMALS; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; NEURONS; RATS; RATS, WISTAR; RECEPTORS, NEUROKININ-1; RECEPTORS, OPIOID, MU; SPINAL CORD; SUBSTANCE P;

EID: 0037052659     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(02)00035-0     Document Type: Article

References (51)

1. Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation
2. μ-Opioid receptors often colocalize with the substance P receptor (NK1) in the trigeminal dorsal horn
3. Physiological properties of the lamina I spinoparabrachial neurons in the rat
4. The NK1 receptor is essential for the full expression of noxious inhibitory controls in the mouse
5. The correlation between the distribution of the NK1 receptor and the actions of tachykinin agonists in the dorsal horn of the rat indicates that substance P does not have a functional role on substantia gelatinosa (lamina II) neurons
6. Primary afferent tachykinins are required to experience moderate to intense pain
7. Spinal lamina I neurons that express neurokinin 1 receptors: Morphological analysis
8. Spinothalamic and spinohypothalamic tract neurons in the cervical enlargement of rats. II. Responses to innocuous and noxious mechanical and thermal stimuli
9. Ultrastructural immunocytochemical localization of excitatory amino acids in the somatosensory system
10. Altered nociception, analgesia and aggression in mice lacking the receptor for substance P
11. Spinoparabrachial tract neurons showing substance P receptor-like immunoreactivity in the lumbar spinal cord of the rat
12. Combined application of excitatory amino acids and substance P produces long-lasting changes in responses of primate spinothalamic tract neurons
13. Enhancement of spinothalamic neuron responses to chemical and mechanical stimuli following combined micro-iontophoretic application of N-methyl-D-aspartic acid and substance P
14. Substance P receptor (neurokinin-1)-expressing neurons in lamina I of the spinal cord encode for the intensity of noxious stimulation: A c-Fos study in rat
15. Golgi studies in the substantia gelatinosa neurons in the spinal trigeminal nucleus
16. Nociceptive and thermoreceptive lamina I neurons are anatomically distinct
17. NK1 (substance P) receptor antagonists - Why are they not analgesic in humans?
18. Neurobiotin, a useful neuroanatomical tracer for in vivo anterograde, retrograde and transneuronal tract-tracing and for in vitro labeling of neurons
19. Spinal lamina I projection neurons in the rat: Collateral innervation of parabrachial area and thalamus
20. Disconnecting pain form the brain by eliminating spinal cord substance P receptor-expressing neurones with SP-PE
21. Opiate analgesics inhibit substance P release from rat trigeminal nucleus
22. A biotin-containing compound N-(2-aminoethyl)biotinamide for intracellular labeling and neuronal tracing studies: Comparison with biocytin
23. Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene
24. Relationship of substance P to afferent characteristics of dorsal root ganglion neurones in guinea-pig
25. The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat
26. Local circuit neurons showing calbindin D28k-immunoreactivity in the substantia gelatinosa of the medullary dorsal horn of the rat. An immunohistochemical study combined with intracellular staining in slice preparation
27. Intracellular labeling study of neurons in the superficial part of the magnocellular layer of the medullary dorsal horn of the rat
28. A Golgi study of the neuronal population of the marginal zone (lamina I) of the rat spinal cord
29. The spinothalamic system of the rat: Structural types of retrogradely labelled neurons in the marginal zone (lamina I)
30. Morphological types of spinomesencephalic neurons in the marginal zone (lamina I) of the rat spinal cord, as shown after retrograde labelling with cholera toxin subunit B
31. The spino-latero-reticular system of the rat: Projections from the superficial dorsal horn and structural characterization of marginal neurons involved
32. The types of neuron in spinal dorsal horn which possess neurokinin-1 receptors
33. Synaptic relationship between substance P and the substance P receptor: Light and electron microscopic characterization of the mismatch between neuropeptides and their receptors
34. Expression of mu- and kappa-, but not delta-, opioid receptor mRNAs is enhanced in the spinal dorsal horn of the arthritic rats
35. Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation
36. Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor
37. Neurokinin-1 receptors on lumbar spinothalamic neurons in the rat
38. Double in situ hybridization study on coexistence of mu-, delta- and kappa-opioid receptor mRNAs with preprotachykinin A mRNA in the rat dorsal root ganglia
39. Plateau potential-dependent windup of the response to primary afferent stimuli in rat dorsal horn neurons [In Process Citation]
40. Cells in laminae III and IV of the rat spinal cord which possess the neurokinin-1 receptor receive monosynaptic input from myelinated primary afferents
41. Cells in laminae III and IV of the rat spinal cord that possess the neurokinin-1 receptor and have dorsally directed dendrites receive a major synaptic input from tachykinin-containing primary afferents
42. Transmission of chronic nociception by spinal neurons expressing the substance P receptor
43. Tachykinins potentiate N-methyl-D-aspartate responses in acutely isolated neurons from the dorsal horn
44. Ca(2+)-activated K+ currents in neurones: Types, physiological roles and modulation
45. The intracellular tracer Neurobiotin alters electrophysiological properties of rat neostriatal neurons
46. The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system
47. Primary affernt input to spinal LI neurones expressing neurokinin 1 (NK1) receptors, evidence for both pre- and post-synaptic inhibition by a μ-opioid agonist in the rat
48. Neurokinin 1 receptor expression by neurons in laminae I, III and IV of the rat spinal dorsal horn that project to the brainstem
49. Spinal opioid analgesia: How critical is the regulation of substance P signaling?
50. The effect of neurobiotin on membrane properties and morphology of intracellularly labeled neurons